The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii: resistance mechanisms and implications for therapy
Abstract
Pseudomonas aeruginosa and Acinetobacter baumannii are major nosocomial pathogens worldwide. Both are intrinsically resistant to many drugs and are able to become resistant to virtually any antimicrobial agent. An increasing prevalence of infections caused by multidrug-resistant (MDR) isolates has been reported in many countries. The resistance mechanisms of P. aeruginosa and A. baumannii include the production of beta-lactamases, efflux pumps, and target-site or outer membrane modifications. Resistance to multiple drugs is usually the result of the combination of different mechanisms in a single isolate or the action of a single potent resistance mechanism. There are many challenges in the treatment of MDR P. aeruginosa and A. baumannii, especially considering the absence of new antimicrobials in the drug-development pipeline. In this review, we present the major resistance mechanisms of P. aeruginosa and A. baumannii, and discuss how they can affect antimicrobial therapy, considering recent clinical, microbiological, pharmacokinetic and pharmacodynamic findings of the main drugs used to treat MDR isolates.
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Citations
Cites
Clinically Relevant Chromosomally Encoded Multidrug Resistance Efflux Pumps in Bacteria
Piddock, L. J. V. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.19.2.382-402.2006 · Cited by 1,231
Efflux-mediated antimicrobial resistance
Poole, K. (2005) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dki171 · Cited by 1,082
Microbial Cell Individuality and the Underlying Sources of Heterogeneity
Avery, S. V. (2006) · Nature Reviews Microbiology · doi:10.1038/nrmicro1460 · Cited by 521
Function of Pseudomonas Porins in Uptake and Efflux
Hancock, R. E. W., & Brinkman, F. S. L. (2002) · Annual Review of Microbiology · doi:10.1146/annurev.micro.56.012302.160310 · Cited by 319
Efflux-Mediated Resistance to Tigecycline (GAR-936) in Pseudomonas aeruginosa PAO1
Dean, C. R., Visalli, M. A., Projan, S. J., Sum, P.-E., & Bradford, P. A. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.3.972-978.2003 · Cited by 286
Cited by
Ellington, M. J., Ekelund, O., Aarestrup, F. M., Canton, R., Doumith, M., Giske, C., Grundman, H., Hasman, H., Holden, M. T. G., Hopkins, K. L., et al. (2017) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2016.11.012 · Cited by 603
Mutuku, C., Gazdag, Z., & Melegh, S. (2022) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-022-03334-0 · Cited by 280
Vega, S., & Dowzicky, M. J. (2017) · Annals of Clinical Microbiology and Antimicrobials · doi:10.1186/s12941-017-0222-0 · Cited by 46
Metadata
- Authors
- Zavascki, A. P., Carvalhaes, C. G., Picão, R. C., & Gales, A. C.
- Venue
- Expert Review of Anti-infective Therapy
- Publisher
- Informa UK Limited
- Published
- 2010-01
- Volume
- 8
- Issue
- 1
- Pages
- 71-93
- ISSN
- 1478-7210 (ISSN-L)
- 1744-8336
- OpenAlex
- W2152944378
- Cited by
- 312
- References
- 5
- FWCI
- 8.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii: resistance mechanisms and implications for therapy. https://app.cochat.ai/papers/10.1586/eri.09.108
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- Zavascki, A. P., Carvalhaes, C. G., Picão, R. C., & Gales, A. C. (2010). Multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii: resistance mechanisms and implications for therapy. Expert Review of Anti-infective Therapy. https://doi.org/10.1586/eri.09.108
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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