The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Obesity, insulin resistance and comorbidities? Mechanisms of association
Open accessAbstract
Overall excess of fat, usually defined by the body mass index, is associated with metabolic (e.g. glucose intolerance, type 2 diabetes mellitus (T2DM), dyslipidemia) and non-metabolic disorders (e.g. neoplasias, polycystic ovary syndrome, non-alcoholic fat liver disease, glomerulopathy, bone fragility etc.). However, more than its total amount, the distribution of adipose tissue throughout the body is a better predictor of the risk to the development of those disorders. Fat accumulation in the abdominal area and in non-adipose tissue (ectopic fat), for example, is associated with increased risk to develop metabolic and non-metabolic derangements. On the other hand, observations suggest that individuals who present peripheral adiposity, characterized by large hip and thigh circumferences, have better glucose tolerance, reduced incidence of T2DM and of metabolic syndrome. Insulin resistance (IR) is one of the main culprits in the association between obesity, particularly visceral, and metabolic as well as non-metabolic diseases. In this review we will highlight the current pathophysiological and molecular mechanisms possibly involved in the link between increased VAT, ectopic fat, IR and comorbidities. We will also provide some insights in the identification of these abnormalities.
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“corroborating the hypothesis that visceral obesity favors insulin resistance, as demonstrated in several previous studies [35,36,37].”
From MOSH Syndrome (Male Obesity Secondary Hypogonadism): Clinical Assessment and Possible Therapeutic Approaches (2018) · cites this paper as [37]
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Cites
Adipose Tissue as an Endocrine Organ
Kershaw, E. E., & Flier, J. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0395 · Cited by 5,522
Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome
Wajchenberg, B. L. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.6.0415 · Cited by 2,961
Insulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for Pathogenesis
Dunaif, A. E. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.6.0318 · Cited by 2,776
Critical nodes in signalling pathways: insights into insulin action
Taniguchi, C. M., Emanuelli, B., & Kahn, C. R. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1837 · Cited by 2,760
Pathophysiology of human visceral obesity: an update
Tchernof, A., & Després, J.-P. (2013) · Physiological Reviews · doi:10.1152/physrev.00033.2011 · Cited by 2,583
Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications
Fabbrini, E., Sullivan, S., & Klein, S. (2010) · Hepatology · doi:10.1002/hep.23280 · Cited by 2,100
Developmental Origin of Fat: Tracking Obesity to Its Source
Gesta, S., Tseng, Y.-H., & Kahn, C. R. (2007) · Cell · doi:10.1016/j.cell.2007.10.004 · Cited by 1,508
Body Fat Distribution and Risk of Cardiovascular Disease: An Update
Després, J.-P. (2012) · Circulation · doi:10.1161/circulationaha.111.067264 · Cited by 1,481
The Degree of Masculine Differentiation of Obesities
Vague, J. (1956) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/4.1.20 · Cited by 1,393
Insulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for Pathogenesis
Dunaif, A. E. (1997) · Endocrine Reviews · doi:10.1210/er.18.6.774 · Cited by 1,167
Research works printed but not linked: 1
- Geloneze B, 2006, [Laboratorial evaluation and diagnosis of insulin resistance]., Arq Bras Endocrinol Metabol, 50, 208
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Unraveling the Regulation of Hepatic Metabolism by Insulin
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Adolescent Obesity: Diet Quality, Psychosocial Health, and Cardiometabolic Risk Factors
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Metadata
- Authors
- Castro, A. V. B., Kolka, C. M., Kim, S. P., & Bergman, R. N.
- Affiliations
- Universidade de São Paulo (BR)
- Cedars-Sinai Medical Center (US)
- Venue
- Arquivos Brasileiros de Endocrinologia & Metabologia
- Publisher
- FapUNIFESP (SciELO)
- Published
- 2014-08
- Volume
- 58
- Issue
- 6
- Pages
- 600-609
- ISSN
- 0004-2730 (ISSN-L)
- PMC
- PMC4423826
- OpenAlex
- W2065496456
- Cited by
- 254
- References
- 63
- Citations by year
- 2026: 6 · 2025: 17 · 2024: 14 · 2023: 18 · 2022: 21 · 2021: 35 · 2020: 37 · 2019: 33 · 2018: 29 · 2017: 20 · 2016: 14 · 2015: 10
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc
- Locations
- Arquivos Brasileiros de Endocrinologia & Metabologia (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- PubMed Central (acceptedVersion)
- Americanae (AECID Library) (submittedVersion, cc-by-nc)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R37DK027619, R01DK029867)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- obesity, insulin resistance, visceral adipose tissue, ectopic fat, type 2 diabetes, metabolic syndrome, dyslipidemia, impaired glucose tolerance, non-alcoholic fatty liver disease, polycystic ovary syndrome, comorbidities, body fat distribution
- MeSH terms
- Adipose Tissue, Animals, Endoplasmic Reticulum, Humans, Hyperinsulinism, Insulin Resistance, Mitochondria, Obesity, Oxidation-Reduction, Apoptosis, Oxidative Stress, Risk Assessment, Body Fat Distribution
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