The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Obesity, insulin resistance and comorbidities? Mechanisms of association
Open accessAbstract
Overall excess of fat, usually defined by the body mass index, is associated with metabolic (e.g. glucose intolerance, type 2 diabetes mellitus (T2DM), dyslipidemia) and non-metabolic disorders (e.g. neoplasias, polycystic ovary syndrome, non-alcoholic fat liver disease, glomerulopathy, bone fragility etc.). However, more than its total amount, the distribution of adipose tissue throughout the body is a better predictor of the risk to the development of those disorders. Fat accumulation in the abdominal area and in non-adipose tissue (ectopic fat), for example, is associated with increased risk to develop metabolic and non-metabolic derangements. On the other hand, observations suggest that individuals who present peripheral adiposity, characterized by large hip and thigh circumferences, have better glucose tolerance, reduced incidence of T2DM and of metabolic syndrome. Insulin resistance (IR) is one of the main culprits in the association between obesity, particularly visceral, and metabolic as well as non-metabolic diseases. In this review we will highlight the current pathophysiological and molecular mechanisms possibly involved in the link between increased VAT, ectopic fat, IR and comorbidities. We will also provide some insights in the identification of these abnormalities.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“corroborating the hypothesis that visceral obesity favors insulin resistance, as demonstrated in several previous studies [35,36,37].”
From MOSH Syndrome (Male Obesity Secondary Hypogonadism): Clinical Assessment and Possible Therapeutic Approaches (2018) · cites this paper as [37]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Adipose Tissue as an Endocrine Organ
Kershaw, E. E., & Flier, J. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0395 · Cited by 5,522
Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome
Wajchenberg, B. L. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.6.0415 · Cited by 2,961
Insulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for Pathogenesis
Dunaif, A. E. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.6.0318 · Cited by 2,776
Critical nodes in signalling pathways: insights into insulin action
Taniguchi, C. M., Emanuelli, B., & Kahn, C. R. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1837 · Cited by 2,760
Pathophysiology of human visceral obesity: an update
Tchernof, A., & Després, J.-P. (2013) · Physiological Reviews · doi:10.1152/physrev.00033.2011 · Cited by 2,583
Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications
Fabbrini, E., Sullivan, S., & Klein, S. (2010) · Hepatology · doi:10.1002/hep.23280 · Cited by 2,100
Developmental Origin of Fat: Tracking Obesity to Its Source
Gesta, S., Tseng, Y.-H., & Kahn, C. R. (2007) · Cell · doi:10.1016/j.cell.2007.10.004 · Cited by 1,508
Body Fat Distribution and Risk of Cardiovascular Disease: An Update
Després, J.-P. (2012) · Circulation · doi:10.1161/circulationaha.111.067264 · Cited by 1,481
The Degree of Masculine Differentiation of Obesities
Vague, J. (1956) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/4.1.20 · Cited by 1,393
Insulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for Pathogenesis
Dunaif, A. E. (1997) · Endocrine Reviews · doi:10.1210/er.18.6.774 · Cited by 1,167
Research works printed but not linked: 1
- Geloneze B, 2006, [Laboratorial evaluation and diagnosis of insulin resistance]., Arq Bras Endocrinol Metabol, 50, 208
Cited by
Sorted by citations
Microbiota-gut-brain axis: Modulator of host metabolism and appetite
van de Wouw, M., Schellekens, H., Dinan, T. G., & Cryan, J. F. (2017) · The Journal of Nutrition · doi:10.3945/jn.116.240481 · Cited by 461
Unraveling the Regulation of Hepatic Metabolism by Insulin
Titchenell, P. M., Lazar, M. A., & Birnbaum, M. J. (2017) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2017.03.003 · Cited by 457
Sergi, D., Naumovski, N., Heilbronn, L. K., Abeywardena, M., O’Callaghan, N., Lionetti, L., & Luscombe-Marsh, N. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00532 · Cited by 347
Adolescent Obesity: Diet Quality, Psychosocial Health, and Cardiometabolic Risk Factors
Ruiz, L. D., Zuelch, M. L., Dimitratos, S. M., & Scherr, R. E. (2019) · Nutrients · doi:10.3390/nu12010043 · Cited by 336
Obesity, DNA Damage, and Development of Obesity-Related Diseases
Włodarczyk, M., & Nowicka, G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20051146 · Cited by 257
Mitochondria in White, Brown, and Beige Adipocytes
Čedíková, M., Kripnerová, M., Dvořáková, J., Pitule, P., Grundmanova, M., Babuška, V., Müllerová, D., & Kuncová, J. (2016) · Stem Cells International · doi:10.1155/2016/6067349 · Cited by 249
McCrimmon, R. J., Catarig, A.-M., Frias, J. P., Lausvig, N. L., le Roux, C. W., Thielke, D., & Lingvay, I. (2020) · Diabetologia · doi:10.1007/s00125-019-05065-8 · Cited by 184
Matheus, V. A., Monteiro, L., Oliveira, R., Maschio, D. A., & Collares‐Buzato, C. B. (2017) · Experimental Biology and Medicine · doi:10.1177/1535370217708188 · Cited by 170
Obesity: Pathophysiology, monosodium glutamate-induced model and anti-obesity medicinal plants
Hernández-Bautista, R., Mahmoud, A. M., Königsberg, M., & López‐Díazguerrero, N. E. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.12.108 · Cited by 158
Insulin resistance and oxidative marker in women with PCOS
Bannigida, D., Nayak, B. S., & Vijayaraghavan, R. (2018) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2018.1499120 · Cited by 122
Orgah, J. O., He, S., Wang, Y., Jiang, M., Wang, Y., Orgah, E. A., Duan, Y., Zhao, B., Zhang, B., Han, J., et al. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104654 · Cited by 114
Meneses, M. J., Silvestre, R. D., Sousa‐Lima, I., & Macedo, M. P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20164049 · Cited by 118
Panahi, Y., Hosseini, M. S., Khalili, N., Naimi, E., Soflaei, S. S., Majeed, M. A., & Sahebkar, A. (2016) · Nutrition · doi:10.1016/j.nut.2016.03.018 · Cited by 106
Functional food and nutra‐pharmaceutical perspectives of date ( Phoenix dactylifera L.) fruit
Younas, A., Naqvi, S. A., Khan, M. R., Shabbir, M. A., Jatoi, M. A., Anwar, F., Inam‐Ur‐Raheem, M., Saari, N., & Aadil, R. M. (2020) · Journal of Food Biochemistry · doi:10.1111/jfbc.13332 · Cited by 115
Review of antidiabetic fruits, vegetables, beverages, oils and spices commonly consumed in the diet
Beidokhti, M. N., & Jäger, A. K. (2017) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2017.02.031 · Cited by 97
de Lima, V. C. O., Piuvezam, G., Maciel, B. L. L., & Morais, A. H. D. A. (2019) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2018.1542387 · Cited by 92
Faris, M. E., Madkour, M. I., Obaideen, A. K., Dalah, E. Z., Hasan, H. A., Radwan, H. M., Jahrami, H., Hamdy, O., & Mohammad, M. G. (2019) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2019.05.023 · Cited by 91
Diabetes and hepatocellular carcinoma: A pathophysiological link and pharmacological management
Singh, M. K., Das, B. K., Choudhary, S., Gupta, D., & Patil, U. K. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.06.095 · Cited by 80
De Lorenzo, A., Noce, A., Moriconi, E., Rampello, T., Marrone, G., Di Daniele, N., & Rovella, V. (2018) · Nutrients · doi:10.3390/nu10040474 · Cited by 68
Thaipitakwong, T., Supasyndh, O., Rasmi, Y., & Aramwit, P. (2019) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2019.102292 · Cited by 70
Wołosowicz, M., Łukaszuk, B., & Chabowski, A. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17228651 · Cited by 69
Azzini, E., Venneria, E., Ciarapica, D., Foddai, M. S., Intorre, F., Zaccaria, M., Maiani, F., Palomba, L., Barnaba, L., Tubili, C., et al. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/1672567 · Cited by 68
Hepatic PEMT activity mediates liver health, weight gain, and insulin resistance
Wan, S., van der Veen, J. N., N’Goma, J. B., Nelson, R. C., Vance, D. E., & Jacobs, R. L. (2019) · The FASEB Journal · doi:10.1096/fj.201900679r · Cited by 64
Obesity-driven inflammation and cancer risk: A comprehensive review
Lamabadusuriya, D. A., Jayasena, H., Bopitiya, A. K., Silva, A. D. D., & Jayasekera, P. T. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.07.007 · Cited by 68
Inactivation of glycogen synthase kinase-3β (GSK-3β) enhances skeletal muscle oxidative metabolism
Theeuwes, W. F., Gosker, H. R., LANGEN, R. C. J., Verhees, K. J. P., Pansters, N., Schols, A. M. W. J., & Remels, A. H. V. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.09.018 · Cited by 63
Konieczna, J., Abete, I., Galmés, A. M., Babió, N., Colom, A., Zulet, M. Á., Estruch, R., Vidal, J., Toledo, E., Díaz‐López, A., et al. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2018.07.005 · Cited by 62
Abdominal obesity and metabolic syndrome in South Asians: prevention and management
Jayawardena, R., Sooriyaarachchi, P., & Misra, A. (2021) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2021.1982381 · Cited by 59
Hariri, M., Salehi, R., Feizi, A., Mirlohi, M., Ghiasvand, R., & Habibi, N. (2015) · Genes & Nutrition · doi:10.1007/s12263-015-0503-1 · Cited by 53
Fatima, F., & Nawaz, M. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00545 · Cited by 51
Anti-obesity potential of natural methylxanthines
Carrageta, D. F., Dias, T. R., Alves, M. G., Oliveira, P. F., Monteiro, M. P., & Silva, B. M. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.02.001 · Cited by 52
Yang, J., Park, K. W., & Cho, S. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.002405 · Cited by 54
An overview on synthetic and biological activities of cannabidiol (CBD) and its derivatives
Wang, X., Zhang, H., Liu, Y., Yang, X., Yang, B., Li, H., & Chen, L. (2023) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2023.106810 · Cited by 57
da Costa, G. F., Santos, I. B., de Bem, G. F., Cordeiro, V. S. C., da Costa, C. A., de Carvalho, L. C. R. M., Ognibene, D. T., Resende, Â. C., & de Moura, R. S. (2017) · Phytotherapy Research · doi:10.1002/ptr.5898 · Cited by 53
Perumalsamy, S., Zin, N. A. A. M., Widodo, R. T., Ahmad, W. A. W., Vethakkan, S. R., & Huri, H. Z. (2017) · Current Pharmaceutical Design · doi:10.2174/1381612823666170616081256 · Cited by 47
Progression of insulin resistance: A link between risk factors and the incidence of diabetes
Wu, W.-C., Wei, J., Chen, S., Fan, K., Lin, C., Yang, C., Lin, M., Shih, S., Hua, C., Hsein, Y.-C., et al. (2020) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2020.108050 · Cited by 47
Gamede, M. W., Mabuza, L. P., Ngubane, P. S., & Khathi, A. (2019) · Molecules · doi:10.3390/molecules24020340 · Cited by 50
Santos, I. B., de Bem, G. F., da Costa, C. A., de Carvalho, L. C. R. M., de Medeiros, A. F., Silva, D. L. B., Romão, M. H., Soares, R. D. A., Ognibene, D. T., de Moura, R. S., et al. (2020) · Nutrition Research · doi:10.1016/j.nutres.2020.05.006 · Cited by 43
Obesity, Type 2 Diabetes, and the Metabolic Syndrome
Genser, L., Mariolo, J. R. C., Castagneto‐Gissey, L., Panagiotopoulos, S., & Rubino, F. (2016) · Surgical Clinics of North America · doi:10.1016/j.suc.2016.03.013 · Cited by 47
Clark, C. C. T., Ghaedi, E., Arab, A., Pourmasoumi, M., & Hadi, A. (2019) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2019.07.045 · Cited by 41
Zhang, C., Sheng, J., Sarsaiya, S., Shu, F., Liu, T., Tu, X.-Y., Ma, G., Xu, G., Zheng, H.-X., & Zhou, L.-F. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.02.040 · Cited by 40
Spiegeleer, M. D., Paepe, E. D., Meulebroek, L. V., Gies, I., Schepper, J. D., & Vanhaecke, L. (2021) · Molecular Medicine · doi:10.1186/s10020-021-00394-0 · Cited by 45
Lipid parameters in obese and normal weight patients with or without chronic periodontitis
Cury, E. Z., Santos, V. R., Maciel, S. S., Gonçalves, T. E. D., Zimmermann, G. S., Mota, R. M. S., Figueiredo, L. C., & Duarte, P. M. (2017) · Clinical Oral Investigations · doi:10.1007/s00784-017-2095-1 · Cited by 39
The obesity paradox and hypoglycemia in critically ill patients
Plečko, D., Bennett, N., Mårtensson, J., & Bellomo, R. (2021) · Critical Care · doi:10.1186/s13054-021-03795-z · Cited by 39
Sarcopenic obesity and insulin resistance: Application of novel body composition models
Poggiogalle, E., Mendes, I. C., Ong, B., Prado, C. M. M., Mocciaro, G., Mazidi, M., Lubrano, C., Lenzi, A., Donini, L. M., & Siervo, M. (2020) · Nutrition · doi:10.1016/j.nut.2020.110765 · Cited by 40
Perdoncin, M., Konrad, A., Wyner, J. R., Lohana, S., Pillai, S. S., Pereira, D. G., Lakhani, H. V., & Sodhi, K. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.756499 · Cited by 39
Agbaje, A. O., Saner, C. C. S., Zhang, J., Henderson, M., & Tuomainen, T. (2024) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgae004 · Cited by 37
Mansyur, M. A., Bakri, S., Patellongi, I. J., & Rahman, I. A. (2020) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2019.12.001 · Cited by 35
Saito, T., Nishida, M., Saito, M., Tanabe, A., Eitsuka, T., Yuan, S.-H., Ikekawa, N., & Nishida, H. (2016) · Nutrition Research · doi:10.1016/j.nutres.2016.09.004 · Cited by 36
Miola, A., Álvarez‐Villalobos, N. A., Ruiz-Hernández, F. G., Filippis, E. D., Veldić, M., Prieto, M. L., Singh, B., Sánchez-Ruiz, J. A., Núñez, N. A., Gardea‐Resendez, M., et al. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.04.068 · Cited by 33
Fellous, T. G., Maio, F. D., Kalkan, H., Carannante, B., Boccella, S., Petrosino, S., Maione, S., Marzo, V. D., & Iannotti, F. A. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.113859 · Cited by 37
Kaur, J., Kaur, K., Singh, B., Singh, A., & Sharma, S. (2021) · Journal of Food Measurement & Characterization · doi:10.1007/s11694-021-01179-z · Cited by 36
Solomon, A., Negrea, M. O., Cipăian, C. R., Boicean, A., Mihăilă, R. G., Rezi, C., Cristinescu, B. A., Berghea-Neamtu, C. S., Popa, M. L., Teodoru, M., et al. (2023) · Healthcare · doi:10.3390/healthcare11192696 · Cited by 32
Predictors of Insulin Resistance in Children versus Adolescents with Obesity
Lentferink, Y. E., Elst, M. A. J., Knibbe, C. A. J., & van der Vorst, M. M. J. (2017) · Journal of Obesity · doi:10.1155/2017/3793868 · Cited by 34
Plasma sphingomyelins increase in pre-diabetic Korean men with abdominal obesity
Im, S., Park, H., Shon, J., Chung, I.-S., Ho, C.-C., Liu, K.-H., & Song, D. (2019) · PLoS ONE · doi:10.1371/journal.pone.0213285 · Cited by 27
Močnik, M., & Varda, N. M. (2021) · Metabolites · doi:10.3390/metabo11080551 · Cited by 31
Lentferink, Y. E., van der Aa, M. P., van Mill, E. G. A. H., Knibbe, C. A. J., & van der Vorst, M. M. J. (2018) · Nutrition and Diabetes · doi:10.1038/s41387-018-0057-6 · Cited by 31
Bioactive Lipids: Chemistry & Health Benefits
(2020) · Biointerface Research in Applied Chemistry · doi:10.33263/briac106.66766687 · Cited by 27
Kim, J., Bilder, D. H., & Neufeld, T. P. (2018) · Genes & Development · doi:10.1101/gad.305870.117 · Cited by 26
Riva, P., Perretta, S., & Swanström, L. L. (2016) · Surgical Endoscopy · doi:10.1007/s00464-016-5189-y · Cited by 25
Isaksen, V. T., Larsen, M. A., Goll, R., Florholmen, J. R., & Paulssen, E. J. (2016) · BMC Obesity · doi:10.1186/s40608-016-0118-0 · Cited by 25
Fernandez, M. O., Sharma, S., Kim, S., Rickert, E., Hsueh, K., Hwang, V., Olefsky, J. M., & Webster, N. J. G. (2016) · Endocrinology · doi:10.1210/en.2016-1818 · Cited by 25
Self-citationThe Potential Role of Naringin and Naringenin as Nutraceuticals Against Metabolic Syndrome
Massaro, L., Raguzzini, A., Aiello, P., & Villaño, D. (2022) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530322666220827141203 · Cited by 25
L‐López, F., Sarmento‐Cabral, A., Herrero‐Aguayo, V., Gahete, M. D., Castano, J. P., & Luque, R. M. (2017) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13109 · Cited by 23
Weight loss program is associated with decrease α-tocopherol status in obese adults
Hamułka, J., Górnicka, M., Sulich, A., & Frąckiewicz, J. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2018.07.011 · Cited by 23
Oladele, C. A., Akintayo, C. O., Badejogbin, O. C., Oniyide, A. A., Omoaghe, A. O., Agunbiade, T. B., & Olaniyi, K. S. (2021) · Andrologia · doi:10.1111/and.14242 · Cited by 22
Guo, J., Cai, L., Yang, C., Li, B., Wei, J., Lin, Y., Ye, P., Hu, G., & Li, J. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.8919 · Cited by 22
Atawia, R. T., Toque, H. A., Meghil, M. M., Benson, T. W., Yiew, N. K. H., Cutler, C. W., Weintraub, N. L., Caldwell, R. B., & Caldwell, R. W. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20061462 · Cited by 22
Jevtovic, F. (2021) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s328694 · Cited by 22
Dehzad, M. J., Ghalandari, H., Nouri, M., & Askarpour, M. (2023) · Phytotherapy Research · doi:10.1002/ptr.7800 · Cited by 20
Acosta-Cota, S. D. J., Aguilar‐Medina, M., Ramos‐Payán, R., Ruiz-Quiñónez, A. K., Romero-Quintana, J. G., Montes‐Ávila, J., Rendón-Maldonado, J. G., Sánchez‐López, A., Centurión, D., & Osuna‐Martínez, U. (2018) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2018-0353 · Cited by 21
Increased Arterial Stiffness in Adolescents With Obesity
Lentferink, Y. E., Kromwijk, L. A. J., van der Aa, M. P., Knibbe, C. A. J., & van der Vorst, M. M. J. (2019) · Global Pediatric Health · doi:10.1177/2333794x19831297 · Cited by 20
Filbertone Ameliorates Adiposity in Mice Fed a High-Fat Diet via Activation of cAMP Signaling
Moon, Y., Tong, T., Kang, W., & Park, T. (2019) · Nutrients · doi:10.3390/nu11081749 · Cited by 20
de Miranda, F. S., Guimarães, J. P. T., Menikdiwela, K. R., Mabry, B., Dhakal, R., Rahman, R. L., Moussa, H. M., & Moustaïd‐Moussa, N. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111245 · Cited by 19
López‐Pastor, A. R., Infante‐Menéndez, J., González‐Illanes, T., González‐López, P., González‐Rodríguez, Á., García‐Monzón, C., de Céniga, M. V., Esparza, L., Gómez‐Hernández, A., & Escribano, Ó. (2021) · Disease Models & Mechanisms · doi:10.1242/dmm.049173 · Cited by 17
Wu, W., Wu, Y., Yang, J., Sun, D., Wang, Y., Ni, Z., Yang, F., Xie, Y., Tan, X., Li, L., et al. (2022) · BMJ Open · doi:10.1136/bmjopen-2021-052674 · Cited by 17
Adipose vascular endothelial growth factor B is a major regulator of energy metabolism
Chen, Y., Zhao, M., Wang, C., Wen, H., Zhang, Y., Lu, M., Adlat, S., Zheng, T., Zhang, M., Li, D., et al. (2020) · Journal of Endocrinology · doi:10.1530/joe-19-0341 · Cited by 16
Goldberg, H. R., Chin, V. L., Zitsman, J. L., Zhang, C., Williams, K. M., Oberfield, S. E., & Fennoy, I. (2017) · Nutrition in Clinical Practice · doi:10.1177/0884533617690521 · Cited by 17
Lorenzo, P. M., & Crujeiras, A. B. (2021) · Food & Function · doi:10.1039/d0fo01984d · Cited by 16
Guzmán-Ornelas, M.-O., Petri, M. H., Mercado, M. V.-D., Chavarría-Ávila, E., Corona-Meraz, F.-I., Ruíz-Quezada, S. L., Madrigal-Ruíz, P.-M., Castro-Albarrán, J., Sandoval-García, F., & Navarro-Hernández, R. E. (2015) · Journal of Diabetes Research · doi:10.1155/2016/5675739 · Cited by 16
The effects of emodin on insulin resistance in KKAy mice with diabetes mellitus
Xuezheng, L., Bing, S., Zhang, H., Ma, C., Yu, Y., Jing, W., Yumeng, G., & Hongwei, Z. (2018) · Pharmacognosy Magazine · doi:10.4103/pm.pm_362_17 · Cited by 15
Xie, X., Zhang, T., Zhao, S. Z., Li, W., Ma, L., Ding, M., & Liu, Y. (2016) · Lipids in Health and Disease · doi:10.1186/s12944-016-0250-3 · Cited by 15
Encabo, P. G., Christopher, C. N., Lee, K., Normann, A. J., Yunker, A. G., Norris, M. K., Wang, E., & Dieli-Conwright, C. M. (2022) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.14280 · Cited by 14
Marc-Hernández, A., Ruíz-Tóvar, J., Jiménez, J. M., Carbajo, M. A., López, M., Cao, M.-J., & Castro, M. J. (2020) · Obesity Surgery · doi:10.1007/s11695-020-04603-3 · Cited by 14
Deleterious Effects of Overfeeding on Brain Homeostasis and Plasticity in Adult Zebrafish
Ghaddar, B., Bringart, M., d’Hellencourt, C. L., Meilhac, O., & Diotel, N. (2021) · Zebrafish · doi:10.1089/zeb.2020.1962 · Cited by 14
Guerrero, C. G. P., Acosta-Cota, S. D. J., Castro‐Sanchez, F. H., Vergara-Jiménez, M. D. J., Burgueño, E. R. R., Sarmiento‐Sánchez, J. I., Picos‐Corrales, L. A., & Osuna‐Martínez, U. (2019) · International Journal of Environmental Health Research · doi:10.1080/09603123.2019.1680817 · Cited by 14
The Intestinal Thread of Fate: How the Microbiota Shapes the Story of Liver Disease
Acierno, C., Nevola, R., Rinaldi, L., Sasso, F. C., Adinolfi, L. E., & Caturano, A. (2025) · Livers · doi:10.3390/livers5020017 · Cited by 14
Laker, R. C., Egolf, S., Will, S., Lantier, L., McGuinness, O. P., Brown, C. L., Bhagroo, N. V., Oldham, S. N., Kuszpit, K. K., Alfaro, A., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59773-4 · Cited by 15
Yi, B., Jiang, J., Zhu, L., Li, P., Ibrahim, I. M., & Zhu, S. (2015) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2014.12.029 · Cited by 13
Kladnická, I., Čedíková, M., Kripnerová, M., Dvořáková, J., Kohoutová, M., Tůma, Z., Müllerová, D., & Kuncová, J. (2019) · Physiological Research · doi:10.33549/physiolres.934353 · Cited by 13
Júnior, A. D. D. C., Carrilho, L. A. O., Filho, P. N., Cantini, L., Vidal, L., Mendes, M. C. S., Carvalheira, J. B. C., & Saini, K. S. (2025) · Onco · doi:10.3390/onco5040047 · Cited by 18
DNA methylation during human adipogenesis and the impact of fructose
Tini, G., Varma, V., Lombardo, R., Nolen, G. T., Lefebvre, G. C., Descombes, P., Métairon, S., Priami, C., Kaput, J., & Scott‐Boyer, M. (2020) · Genes & Nutrition · doi:10.1186/s12263-020-00680-2 · Cited by 11
Estrada, Y. M. F., Caldas, A. P. S., da Silva, A., & Bressan, J. (2021) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2021.1984401 · Cited by 12
Mohammed, Z., Atouti, N., & Ben, F. A. (2017) · Physical Education of Students · doi:10.15561/20755279.2017.0308 · Cited by 12
Nicotinamide N‐methyltransferase inhibition mitigates obesity‐related metabolic dysfunction
Babula, J. J., Bui, D., Stevenson, H. L., Watowich, S. J., & Neelakantan, H. (2024) · Diabetes Obesity and Metabolism · doi:10.1111/dom.15879 · Cited by 11
Răcătăianu, N., Leach, N. V., Bolboaca, S. D., Cozma, A., Dronca, E., Valea, A., Silaghi, C. A., Bîlc, A.-M., & Ghervan, C. (2018) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365513.2018.1517420 · Cited by 11
Effect of remote nursing monitoring on overweight in women: clinical trial
Palmeira, C. S., Mussi, F. C., Santos, C. A. S. D. T., Lima, M. L., Ladeia, A. M. T., & Silva, L. C. D. J. (2019) · Revista Latino-Americana de Enfermagem · doi:10.1590/1518-8345.2651.3129 · Cited by 13
Comparative effects of energy restriction and resveratrol intake on glycemic control improvement
Milton‐Laskibar, I., Aguirre, L., Macarulla, M. T., Etxeberría, U., Milagro, F. I., Martínez, J. A., Contreras, J., & Portillo, M. P. (2017) · BioFactors · doi:10.1002/biof.1347 · Cited by 11
Kyio, N. H., Turgut, S., Özkan, T., & Çetin, G. (2020) · Obesity Surgery · doi:10.1007/s11695-020-04528-x · Cited by 11
Morus alba: natural and valuable effects in weight loss management
Ntalouka, F., & Tsirivakou, A. (2024) · Frontiers in Clinical Diabetes and Healthcare · doi:10.3389/fcdhc.2024.1395688 · Cited by 10
Boyer, W. R., Toth, L. P., Brenton, M., Augé, R. M., Churilla, J. R., & Fitzhugh, E. C. (2023) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2023.06.002 · Cited by 19
Metadata
- Authors
- Castro, A. V. B., Kolka, C. M., Kim, S. P., & Bergman, R. N.
- Affiliations
- Universidade de São Paulo (BR)
- Cedars-Sinai Medical Center (US)
- Venue
- Arquivos Brasileiros de Endocrinologia & Metabologia
- Publisher
- FapUNIFESP (SciELO)
- Published
- 2014-08
- Volume
- 58
- Issue
- 6
- Pages
- 600-609
- ISSN
- 0004-2730 (ISSN-L)
- PMC
- PMC4423826
- OpenAlex
- W2065496456
- Cited by
- 254
- References
- 63
- Citations by year
- 2026: 6 · 2025: 17 · 2024: 14 · 2023: 18 · 2022: 21 · 2021: 35 · 2020: 37 · 2019: 33 · 2018: 29 · 2017: 20 · 2016: 14 · 2015: 10
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc
- Locations
- Arquivos Brasileiros de Endocrinologia & Metabologia (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- PubMed Central (acceptedVersion)
- Americanae (AECID Library) (submittedVersion, cc-by-nc)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R37DK027619, R01DK029867)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- obesity, insulin resistance, visceral adipose tissue, ectopic fat, type 2 diabetes, metabolic syndrome, dyslipidemia, impaired glucose tolerance, non-alcoholic fatty liver disease, polycystic ovary syndrome, comorbidities, body fat distribution
- MeSH terms
- Adipose Tissue, Animals, Endoplasmic Reticulum, Humans, Hyperinsulinism, Insulin Resistance, Mitochondria, Obesity, Oxidation-Reduction, Apoptosis, Oxidative Stress, Risk Assessment, Body Fat Distribution
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
