Metabolic syndrome and psychiatric disorders: a population-based study
Open accessAbstract
OBJECTIVE: To identify the association of metabolic syndrome (MetS) and psychiatric disorders in young adults in southern Brazil. METHODS: This population based cross-sectional study involved a total of 1,023 young adults between the ages of 21 and 32 years. Current episodes of psychiatric disorders were assessed using the Mini International Neuropsychiatric Interview - Plus version. MetS was evaluated using the National Cholesterol Education Program Adult Treatment Panel III (NCEP/ATP III). RESULTS: Of the 1,023 participants, 24.3% were identified with MetS, 13.5% were diagnosed with anxiety disorders, 7.5% with current depression, 3.9% with bipolar disorders and 10.1% were at risk of suicide. MetS was associated with ethnicity (p = 0.022), excess weight (p < 0.001), current anxiety disorders (p < 0.001), current mood disorders (bipolar disorder in mood episode and current depression) (p < 0.001), and suicide risk (p < 0.001). CONCLUSIONS: MetS was associated with psychiatric disorders. Awareness of factors associated with MetS can help identify high-risk individuals and stimulate disease prevention and control programs, as well as lifestyle changes.
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Multiple epidemiological and clinical studies report an association between metabolic syndrome and suicidal attempts.
“Multiple epidemiological and clinical studies have reported an association between metabolic syndrome and suicidal attempts (83–85), but the directionality and causality of this relationship remain unresolved.”
From Exploring the neurobiological markers of suicidal behaviors in pediatric population: a narrative review (2026) · cites this paper as [84]
The Discussion (page not provided) reports an association between metabolic syndrome and suicide risk in this study and cites a study finding more lifetime suicide attempts among patients with metabolic syndrome. It says few studies have examined suicide risk, however, and does not establish that multiple studies reported an association specifically with suicide attempts. (LLM, conf=0.84)
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Salehi, M., Saeidi, M., Amanat, M., Barias, T., Anyeji, U., Alzein, O., & Gunturu, S. (2026) · Frontiers in Pediatrics · doi:10.3389/fped.2026.1738009
- Authors
- Moreira, F. P., Jansen, K., Cardoso, T. D. A., Mondin, T. C., Magalhães, P. V., Kapczinski, F., Souza, L. D. M., da Silva, R. A., Oses, J. P., & Wiener, C. D.
- Affiliations
- Universidade Católica de Pelotas (BR)
- Universidade Federal do Rio Grande do Sul (BR)
- Universidade Federal do Rio Grande do Sul (UFRGS), Brazil; McMaster University, Canada
- Universidade Católica de Pelotas (UCPel), Brazil
- ORCID
- Venue
- Brazilian Journal of Psychiatry
- Publisher
- EDITORA SCIENTIFIC
- Published
- 2019-02
- Volume
- 41
- Issue
- 1
- Pages
- 38-43
- ISSN
- 1516-4446 (ISSN-L)
- 1809-452X
- PMC
- PMC6781708
- OpenAlex
- W2896349507
- Cited by
- 44
- References
- 46
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 6 · 2023: 7 · 2022: 4 · 2021: 9 · 2020: 7
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Brazilian Journal of Psychiatry (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-sa)
- Americanae (AECID Library) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Keywords
- metabolic syndrome, mental illness, young adults, anxiety disorders, depression, bipolar disorder, suicide risk, overweight, ethnicity, southern Brazil
- MeSH terms
- Adult, Mental Disorders, Brazil, Cross-Sectional Studies, Female, Humans, Socioeconomic Factors, Prevalence, Metabolic Syndrome, Young Adult
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