Lipolysis and lipases in white adipose tissue – An update
Open accessAbstract
Lipolysis is defined as the sequential hydrolysis of triacylglycerol (TAG) stored in cell lipid droplets. For many years, it was believed that hormone-sensitive lipase (HSL) and monoacylglycerol lipase (MGL) were the main enzymes catalyzing lipolysis in the white adipose tissue. Since the discovery of adipose triglyceride lipase (ATGL) in 2004, many studies were performed to investigate and characterize the actions of this lipase, as well as of other proteins and possible regulatory mechanisms involved, which reformulated the concept of lipolysis. Novel findings from these studies include the identification of lipolytic products as signaling molecules regulating important metabolic processes in many non-adipose tissues, unveiling a previously underestimated aspect of lipolysis. Thus, we present here an updated review of concepts and regulation of white adipocyte lipolysis with a special emphasis in its role in metabolism homeostasis and as a source of important signaling molecules.
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AKG-induced WAT lipolysis is indicated by upregulated RER and increased expression of ATGL and p-HSL.
“Similar AKG‐induced WAT lipolysis was also indicated by upregulated RER and increased expression of ATGL and p‐HSL, the main enzymes catalyzing lipolysis in WAT (Bolsoni‐Lopes & Alonso‐Vale, 2015).”
From Exercise‐induced α‐ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1‐dependent adrenal activation (2020) · cites this paper as Bolsoni‐Lopes & Alonso‐Vale, 2015
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Fat Mobilization in Adipose Tissue Is Promoted by Adipose Triglyceride Lipase
Zimmermann, R., Bogner‐Strauß, J. G., Haemmerle, G., Schoiswohl, G., Birner‐Gruenberger, R., Riederer, M., Lass, A., Neuberger, G., Eisenhaber, F., Hermetter, A., et al. (2004) · Science · doi:10.1126/science.1100747 · Cited by 2,121 · see citing works
Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase
Haemmerle, G., Lass, A., Zimmermann, R., Gorkiewicz, G., Meyer, C., Rozman, J., Heldmaier, G., Maier, R., Theussl, C., Eder, S., et al. (2006) · Science · doi:10.1126/science.1123965 · Cited by 1,375 · see citing works
FAT SIGNALS - Lipases and Lipolysis in Lipid Metabolism and Signaling
Zechner, R., Zimmermann, R., Eichmann, T. O., Kohlwein, S., Haemmerle, G., Lass, A., & Madeo, F. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2011.12.018 · Cited by 1,105 · see citing works
Regulation of Lipolysis in Adipocytes
Duncan, R. E., Ahmadian, M., Jaworski, K., Sarkadi-Nagy, E., & Sul, H. S. (2007) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.27.061406.093734 · Cited by 1,021 · see citing works
Brasaemle, D. (2007) · Journal of Lipid Research · doi:10.1194/jlr.r700014-jlr200 · Cited by 997 · see citing works
Lipolysis and lipid mobilization in human adipose tissue
Lafontan, M., & Langin, D. (2009) · Progress in Lipid Research · doi:10.1016/j.plipres.2009.05.001 · Cited by 825 · see citing works
Jenkins, C. M., Mancuso, D. J., Yan, W., Sims, H. F., Gibson, B., & Gross, R. W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407841200 · Cited by 778 · see citing works
ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1
Haemmerle, G., Moustafa, T., Wölkart, G., Büttner, S., Schmidt, A. G., van de Weijer, T., Hesselink, M. K. C., Jaeger, D., Kienesberger, P. C., Zierler, K. A., et al. (2011) · Nature Medicine · doi:10.1038/nm.2439 · Cited by 767 · see citing works
Adipose tissue as a buffer for daily lipid flux
Frayn, K. (2002) · Diabetologia · doi:10.1007/s00125-002-0873-y · Cited by 752 · see citing works
Schweiger, M., Schreiber, R., Haemmerle, G., Lass, A., Fledelius, C., Jacobsen, P., Tornqvist, H. E., Zechner, R., & Zimmermann, R. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m608048200 · Cited by 728 · see citing works
Free Fatty Acids and Pathogenesis of Type 2 Diabetes Mellitus
Bergman, R. N., & Ader, M. (2000) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(00)00323-4 · Cited by 622 · see citing works
Haemmerle, G., Zimmermann, R., Hayn, M., Theussl, C., Waeg, G., Wagner, E., Sattler, W., Magin, T. M., Wagner, E. F., & Zechner, R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110355200 · Cited by 613 · see citing works
Villena, J. A., Roy, S., Sarkadi‐Nagy, E., Kim, K., & Sul, H. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403855200 · Cited by 606 · see citing works
Absence of perilipin results in leanness and reverses obesity in Leprdb/db mice
Martı́nez-Botas, J., Anderson, J. B., Tessier, D., Lapillonne, A., Chang, B. H., Quast, M. J., Gorenstein, D. G., Chen, K.-H., & Chan, L. (2000) · Nature Genetics · doi:10.1038/82630 · Cited by 580 · see citing works
Adipose Development: From Stem Cell to Adipocyte
Otto, T. C., & Lane, M. D. (2005) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230591008189 · Cited by 531 · see citing works
Desnutrin/ATGL Is Regulated by AMPK and Is Required for a Brown Adipose Phenotype
Ahmadian, M., Abbott, M. J., Tang, T., Hudak, C. S. S., Kim, Y., Bruss, M. D., Hellerstein, M. K., Lee, H., Samuel, V. T., Shulman, G. I., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.05.002 · Cited by 526 · see citing works
PPARs: Fatty acid sensors controlling metabolism
Poulsen, L. L. C., Siersbæk, M. S., & Mandrup, S. (2012) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2012.01.003 · Cited by 510 · see citing works
Wu, X.-D., Motoshima, H., Mahadev, K., Stalker, T. J., Scalia, R., & Goldstein, B. (2003) · Diabetes · doi:10.2337/diabetes.52.6.1355 · Cited by 471 · see citing works
Anthonsen, M. W., Rönnstrand, L., Wernstedt, C., Degerman, E., & Holm, C. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.1.215 · Cited by 468 · see citing works
Kimmel, A. R., Brasaemle, D., McAndrews-Hill, M., Sztalryd, C., & Londos, C. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r000034 · Cited by 454 · see citing works
Londos, C., Brasaemle, D., Schultz, C. J., Segrest, J. P., & Kimmel, A. R. (1999) · Seminars in Cell and Developmental Biology · doi:10.1006/scdb.1998.0275 · Cited by 435 · see citing works
The Production and Release of Glycerol by Adipose Tissue Incubated in Vitro
Vaughan, M. M. (1962) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70821-7 · Cited by 428 · see citing works
A futile metabolic cycle activated in adipocytes by antidiabetic agents
Guan, H.-P., Li, Y., Jensen, M. V., Newgard, C. B., Steppan, C. M., & Lazar, M. A. (2002) · Nature Medicine · doi:10.1038/nm780 · Cited by 427 · see citing works
cDNA Cloning, Tissue Distribution, and Identification of the Catalytic Triad of Monoglyceride Lipase
Karlsson, M., Contreras, J. A., Hellman, U., Tornqvist, H. E., & Holm, C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.43.27218 · Cited by 423 · see citing works
Dissecting adipose tissue lipolysis: molecular regulation and implications for metabolic disease
Nielsen, T. S., Jessen, N., Jørgensen, J. O. L., Møller, N., & Lund, S. A. (2014) · Journal of Molecular Endocrinology · doi:10.1530/jme-13-0277 · Cited by 380 · see citing works
Ong, K. T., Mashek, M. T., Bu, S. Y., Greenberg, A. S., & Mashek, D. G. (2010) · Hepatology · doi:10.1002/hep.24006 · Cited by 339 · see citing works
ATGL has a key role in lipid droplet/adiposome degradation in mammalian cells
Smirnova, E., Goldberg, E. B., Makarova, K. S., Lin, L., Brown, W. J., & Jackson, C. L. (2005) · EMBO Reports · doi:10.1038/sj.embor.7400559 · Cited by 338 · see citing works
Guzmán, M., Lo Verme, J., Fu, J., Oveisi, F., Blázquez, C., & Piomelli, D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404087200 · Cited by 328 · see citing works
Regulation of Triglyceride Metabolism.IV. Hormonal regulation of lipolysis in adipose tissue
Jaworski, K., Sarkadi‐Nagy, E., Duncan, R. E., Ahmadian, M., & Sul, H. S. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00554.2006 · Cited by 300 · see citing works
Taschler, U., Radner, F. P. W., Heier, C., Schreiber, R., Schweiger, M., Schoiswohl, G., Preiss-Landl, K., Jaeger, D., Reiter, B., Köfeler, H. C., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.215434 · Cited by 284 · see citing works
Role of AMP-activated protein kinase in adipose tissue metabolism and inflammation
Bijland, S., Mancini, S. J., & Salt, I. P. (2013) · Clinical Science · doi:10.1042/cs20120536 · Cited by 283 · see citing works
Guyenet, S. J., & Schwartz, M. W. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2525 · Cited by 281 · see citing works
Metabolism of lipids in human white adipocyte
Large, V., Peroni, O. D., Letexier, D., Ray, H., & Beylot, M. (2004) · Diabetes & Metabolism · doi:10.1016/s1262-3636(07)70121-0 · Cited by 275 · see citing works
Insulin signalling mechanisms for triacylglycerol storage
Czech, M., Tencerová, M., Pedersen, D. J., & Aouadi, M. (2013) · Diabetologia · doi:10.1007/s00125-013-2869-1 · Cited by 272 · see citing works
Toh, S. Y., Gong, J., Du, G., Li, J. Z., Yang, S., Ye, J., Yao, H., Zhang, Y., Xue, B., Li, Q., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002890 · Cited by 267 · see citing works
Jaworski, K., Ahmadian, M., Duncan, R. E., Sarkadi‐Nagy, E., Varady, K. A., Hellerstein, M. K., Lee, H., Samuel, V. T., Shulman, G. I., Kim, K.-H., et al. (2009) · Nature Medicine · doi:10.1038/nm.1904 · Cited by 260 · see citing works
CGI-58 Interacts with Perilipin and Is Localized to Lipid Droplets
Yamaguchi, T., Omatsu, N., Matsushita, S., & Osumi, T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403920200 · Cited by 258 · see citing works
Chakrabarti, P., English, T., Shi, J., Smas, C. M., & Kandror, K. V. (2010) · Diabetes · doi:10.2337/db09-1602 · Cited by 228 · see citing works
Bézaire, V., Mairal, A., Ribet, C., Lefort, C., Girousse, A., Jocken, J. W. E., Laurencikiene, J., Anesia, R., Rodriguez, A., Rydén, M., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.008631 · Cited by 219 · see citing works
Eichmann, T. O., Kumari, M., Haas, J. T., Farese, R. V., Zimmermann, R., Lass, A., & Zechner, R. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.400416 · Cited by 216 · see citing works
Ahmadian, M., Wang, Y., & Sul, H. S. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.12.009 · Cited by 211 · see citing works
PPARγ regulates adipose triglyceride lipase in adipocytes in vitro and in vivo
Kershaw, E. E., Schupp, M., Guan, H.-P., Gardner, N. P., Lazar, M. A., & Flier, J. S. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00122.2007 · Cited by 209 · see citing works
Gaidhu, M. P., Fediuc, S., Anthony, N. M., So, M., Mirpourian, M., Perry, R. L. S., & Ceddia, R. B. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800480-jlr200 · Cited by 200 · see citing works
Adipose Overexpression of Desnutrin Promotes Fatty Acid Use and Attenuates Diet-Induced Obesity
Ahmadian, M., Duncan, R. E., Varady, K. A., Frasson, D., Hellerstein, M. K., Birkenfeld, A. L., Samuel, V. T., Shulman, G. I., Wang, Y., Kang, C., et al. (2009) · Diabetes · doi:10.2337/db08-1644 · Cited by 199 · see citing works
Identification and Functional Characterization of Adipose-specific Phospholipase A2 (AdPLA)
Duncan, R. E., Sarkadi‐Nagy, E., Jaworski, K., Ahmadian, M., & Sul, H. S. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804146200 · Cited by 168 · see citing works
Pagnon, J. C., Matzaris, M., Stark, R., Meex, R. C. R., Macaulay, S. L., Brown, W. A., O’Brien, P. E., Tiganis, T., & Watt, M. J. (2012) · Endocrinology · doi:10.1210/en.2012-1127 · Cited by 163 · see citing works
Efficient Phagocytosis Requires Triacylglycerol Hydrolysis by Adipose Triglyceride Lipase
Chandak, P. G., Radović, B., Aflaki, E., Kolb, D., Buchebner, M., Fröhlich, E., Magnes, C., Sinner, F., Haemmerle, G., Zechner, R., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.107854 · Cited by 163 · see citing works
Mutational Analysis of the Hormone-sensitive Lipase Translocation Reaction in Adipocytes
Su, C., Sztalryd, C., Contreras, J. A., Holm, C., Kimmel, A. R., & Londos, C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301809200 · Cited by 146 · see citing works
Festuccia, W. T., Laplante, M., Berthiaume, M., Gélinas, Y., & Deshaies, Y. (2006) · Diabetologia · doi:10.1007/s00125-006-0336-y · Cited by 140 · see citing works
Mauriège, P., Pergola, G. D., Berlan, M., & Lafontan, M. (1988) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38502-3 · Cited by 121 · see citing works
Differential control of ATGL-mediated lipid droplet degradation by CGI-58 and G0S2
Lü, X., Yang, X., & Liu, J. (2010) · Cell Cycle · doi:10.4161/cc.9.14.12181 · Cited by 118 · see citing works
Grahn, T. H. M., Kaur, R., Yin, J., Schweiger, M., Sharma, V. M., Lee, M., Ido, Y., Smas, C. M., Zechner, R., Lass, A., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.539890 · Cited by 117 · see citing works
Tang, T., Abbott, M. J., Ahmadian, M., Lopes, A. B., Wang, Y., & Sul, H. S. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.10.012 · Cited by 115 · see citing works
Advances in adipose tissue metabolism
Lafontan, M. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.237 · Cited by 111 · see citing works
Metabolic Adaptations in the Absence of Perilipin
Saha, P., Kojima, H., Martı́nez-Botas, J., Sunehag, A. L., & Chan, L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405499200 · Cited by 104 · see citing works
Adipose triglyceride lipase plays a key role in the supply of the working muscle with fatty acids
Schoiswohl, G., Schweiger, M., Schreiber, R., Gorkiewicz, G., Preiss-Landl, K., Taschler, U., Zierler, K. A., Radner, F. P. W., Eichmann, T. O., Kienesberger, P. C., et al. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m001073 · Cited by 103 · see citing works
Interaction of the Adipocyte Fatty Acid-binding Protein with the Hormone-sensitive Lipase
Smith, A. J., Thompson, B. R., Sanders, M. A., & Bernlohr, D. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703730200 · Cited by 100 · see citing works
Adipocyte lipases and lipid droplet-associated proteins: insight from transgenic mouse models
Girousse, A., & Langin, D. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.113 · Cited by 93 · see citing works
A1 Adenosine Receptor: Role in Diabetes and Obesity
Dhalla, A. K., Chisholm, J. W., Reaven, G. M., & Belardinelli, L. (2009) · Handbook of experimental pharmacology · doi:10.1007/978-3-540-89615-9_9 · Cited by 92 · see citing works
Lopes, A. B., Festuccia, W. T., Farias, T. S. M., Chimin, P., Torres‐Leal, F. L., Derogis, P. B. M. C., de Andrade, P. B., Miyamoto, S., Lima, F. B., Curi, R., et al. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00082.2013 · Cited by 91 · see citing works
Self-citationPerilipin overexpression in mice protects against diet-induced obesity
Miyoshi, H., Souza, S. C., Endo, M., Sawada, T., Perfield, J. W., Shimizu, C., Stancheva, Z. S., Nagai, S., Strissel, K. J., Yoshioka, N., et al. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m002352 · Cited by 84 · see citing works
Regulation of adipose tissue lipolysis revisited
Bézaire, V., & Langin, D. (2009) · Proceedings of The Nutrition Society · doi:10.1017/s0029665109990279 · Cited by 77 · see citing works
Castro-Chávez, F., Yechoor, V. K., Saha, P., Martı́nez-Botas, J., Wooten, E. C., Sharma, S., O'Connell, P., Taegtmeyer, H., & Chan, L. (2003) · Diabetes · doi:10.2337/diabetes.52.11.2666 · Cited by 72 · see citing works
Interaction between the Triglyceride Lipase ATGL and the Arf1 Activator GBF1
Ellong, E. N., Soni, K. G., Bui, Q. T., Sougrat, R., Golinelli‐Cohen, M., & Jackson, C. L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021889 · Cited by 61 · see citing works
Effects of fenofibrate on lipid metabolism in adipose tissue of rats
Ferreira, A. V. M., Parreira, G. G., Green, A., & Botion, L. M. (2006) · Metabolism · doi:10.1016/j.metabol.2006.01.020 · Cited by 44 · see citing works
Lucas, S., Tavernier, G., Tiraby, C., Mairal, A., & Langin, D. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m200250-jlr200 · Cited by 44 · see citing works
Xie, X., Langlais, P. R., Zhang, X., Heckmann, B. L., Saarinen, A. M., Mandarino, L. J., & Liu, J. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00663.2013 · Cited by 39 · see citing works
Endothelial dysfunction in adipose triglyceride lipase deficiency
Schrammel, A., Mußbacher, M., Wölkart, G., Stessel, H., Pail, K., Winkler, S., Schweiger, M., Haemmerle, G., Zoughbi, W. A., Höfler, G., et al. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.03.005 · Cited by 35 · see citing works
Flagged first, then by citations
1 of the 69 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma
Du, D., Liu, C., Qin, M., Zhang, X., Xi, T., Yuan, S., Hao, H., & Xiong, J. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.09.019 · Cited by 649 · see citing works
Regulation and Metabolic Significance of De Novo Lipogenesis in Adipose Tissues
Song, Z., Xiaoli, A. M., & Yang, F. (2018) · Nutrients · doi:10.3390/nu10101383 · Cited by 437 · see citing works
The ménage à trois of autophagy, lipid droplets and liver disease
Filali-Mouncef, Y., Hunter, C., Roccio, F., Zagkou, S., Dupont, N., Primard, C., Proikas‐Cezanne, T., & Reggiori, F. (2021) · Autophagy · doi:10.1080/15548627.2021.1895658 · Cited by 375 · see citing works
Liu, X., Liang, Y., Song, R., Yang, G., Han, J., Lan, Y., Pan, S., Zhu, M., Liu, Y., Wang, Y., et al. (2018) · Molecular Cancer · doi:10.1186/s12943-018-0838-5 · Cited by 252 · see citing works
Zhang, T., Chen, J., Tang, X., Luo, Q., Xu, D., & Yu, B. (2019) · Lipids in Health and Disease · doi:10.1186/s12944-019-1170-9 · Cited by 150 · see citing works
There and Back Again: Leptin Actions in White Adipose Tissue
Martínez‐Sánchez, N. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176039 · Cited by 135 · see citing works
Regmi, A., Aihara, E., Christe, M. E., Varga, G., Beyer, T. P., Ruan, X., Beebe, E., O’Farrell, L. S., Bellinger, M. A., Austin, A. K., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.05.010 · Cited by 139 · see citing works
An Overview of Hormone-Sensitive Lipase (HSL)
Althaher, A. R. (2022) · The Scientific World Journal · doi:10.1155/2022/1964684 · Cited by 129 · see citing works
Immobilization of Lipase A from Candida antarctica onto Chitosan-Coated Magnetic Nanoparticles
Monteiro, R. R. C., Lima, P. J. M., Pinheiro, B. B., Freire, T. M., Dutra, L. M. U., Fechine, P. B. A., Gonçalves, L. R. B., de Souza, M. C. M., dos Santos, J. C. S., & Fernández‐Lafuente, R. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20164018 · Cited by 111 · see citing works
Lipid metabolism in insect disease vectors
Gondim, K. C., Atella, G. C., Pontes, E. G., & Majerowicz, D. (2018) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2018.08.005 · Cited by 109 · see citing works
Bełtowski, J., Wójcicka, G., & Jamróz-Wiśniewska, A. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.01.004 · Cited by 95 · see citing works
Yuan, Y., Xu, P., Jiang, Q., Cai, X., Wang, T., Peng, W., Sun, J., Zhu, C., Zhang, C., Yue, D., et al. (2020) · The EMBO Journal · doi:10.15252/embj.2019103304 · Cited by 92 · see citing works
“Similar AKG-induced WAT lipolysis was also indicated by upregulated RER and increased expression of ATGL and p-HSL, the main enzymes catalyzing lipolysis in WAT (Bolsoni-Lopes & Alonso-Vale, 2015).”
Aguilar‐Cázares, D., Chavez-Dominguez, R., Marroquin-Muciño, M., Perez-Medina, M., Benito-Lopez, J. J., Camarena, Á., Rumbo‐Nava, U., & López-González, J. S. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.929572 · Cited by 85 · see citing works
Genes, transcription factors and enzymes involved in lipid metabolism in fin fish
Ayisi, C. L., Yamei, C., & Zhao, J.-L. (2017) · Agri Gene · doi:10.1016/j.aggene.2017.09.006 · Cited by 79 · see citing works
Matar, D. B., Zhra, M., Nassar, W. K., Altemyatt, H., Naureen, A., Abotouk, N., Elahi, M. A., & Aljada, A. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1592683 · Cited by 80 · see citing works
Ferreri, C., Sansone, A., Rosaria, F., Amézaga, J., & Tueros, I. (2020) · Metabolites · doi:10.3390/metabo10090345 · Cited by 65 · see citing works
SARS-CoV-2 infects adipose tissue in a fat depot- and viral lineage-dependent manner
Saccon, T. D., Mousovich‐Neto, F., Ludwig, R. G., Carregari, V. C., Souza, A. B. D. A., dos Passos, A. S. C., Martini, M. C., Barbosa, P. P., de Souza, G. F., Muraro, S. P., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33218-8 · Cited by 65 · see citing works
Ye, Q. H., Tan, J., Xiao-Rong, H., Wang, C., Liu, X., Li, C., Fang, Z., Chen, H., Liu, Y., Chen, S., et al. (2024) · International Journal of Food Science & Technology · doi:10.1111/ijfs.16912 · Cited by 60 · see citing works
Rahman, S. M. K., Uyama, T., Hussain, Z., & Ueda, N. (2021) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-043020-090216 · Cited by 58 · see citing works
Berezin, A. Е., Berezin, A. A., & Lichtenauer, M. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.583175 · Cited by 55 · see citing works
Hydrogen Sulfide in the Adipose Tissue—Physiology, Pathology and a Target for Pharmacotherapy
Bełtowski, J., & Jamróz-Wiśniewska, A. (2016) · Molecules · doi:10.3390/molecules22010063 · Cited by 54 · see citing works
Interplay between Lipid Metabolism, Lipid Droplets, and DNA Virus Infections
Farías, M. A., Diethelm‐Varela, B., Navarro, A. J., Kalergis, A. M., & González, P. A. (2022) · Cells · doi:10.3390/cells11142224 · Cited by 50 · see citing works
Bordicchia, M., Ceresiani, M., Pavani, M., Minardi, D., Polito, M., Wabitsch, M., Cannone, V., Burnett, J. C. J., Dessı̀-Fulgheri, P., & Sarzani, R. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00499.2015 · Cited by 48 · see citing works
Xu, H., Lyu, X., Guo, X., Yang, H., Duan, L., Zhu, H., Pan, H., Gong, F., & Wang, L. (2022) · Nutrients · doi:10.3390/nu14091898 · Cited by 47 · see citing works
Adipocyte PHLPP2 inhibition prevents obesity-induced fatty liver
Kim, K., Kang, J. K., Jung, Y. H., Lee, S. B., Rametta, R., Dongiovanni, P., Valenti, L. V. C., & Pajvani, U. B. (2021) · Nature Communications · doi:10.1038/s41467-021-22106-2 · Cited by 46 · see citing works
Molecular mechanism of benzo [a] pyrene regulating lipid metabolism via aryl hydrocarbon receptor
Lou, W., Zhang, M.-D., Chen, Q., Bai, T., Hu, Y., Gao, F., Li, J., Lv, X., Zhang, Q., & Chang, F. (2022) · Lipids in Health and Disease · doi:10.1186/s12944-022-01627-9 · Cited by 46 · see citing works
Tian, N., Liu, Q., Li, Y., Tong, L., Lu, Y., Zhu, Y., Zhang, P., Chen, H., Hu, L., Meng, J., et al. (2020) · Diabetes · doi:10.2337/db19-1087 · Cited by 46 · see citing works
Ceramide and sphingosine 1-phosphate in adipose dysfunction
Fang, Z., Pyne, S., & Pyne, N. J. (2019) · Progress in Lipid Research · doi:10.1016/j.plipres.2019.04.001 · Cited by 45 · see citing works
Yang, M., Luo, S., Yang, J., Chen, W., He, L., Liu, D., Zhao, L., & Wang, X. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1017387 · Cited by 46 · see citing works
Chen, Y., Chen, L., Wu, X., Zhao, Y., Wang, Y., Jiang, D., Liu, X., Zhou, T., Li, S., Wei, Y., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37247-9 · Cited by 43 · see citing works
Sun, J. H., Ji, H., Li, X., Shi, X., Du, Z., & Chen, L. (2016) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2016.04.008 · Cited by 41 · see citing works
Xu, H., Wang, L., Yan, K., Zhu, H., Pan, H., Yang, H., Liu, M., & Gong, F. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.632236 · Cited by 35 · see citing works
Qin, H., Xu, H., Yu, L., Yang, L., Lin, C., & Chen, J. (2019) · Food & Nutrition Research · doi:10.29219/fnr.v63.3637 · Cited by 34 · see citing works
The vesicular transporter STX11 governs ATGL-mediated hepatic lipolysis and lipophagy
Zhang, G., Han, J., Wang, L., Yang, X., Yan, Z., Qu, M., Zhou, H., Bilal, H., Wang, F., Ge, H., et al. (2022) · iScience · doi:10.1016/j.isci.2022.104085 · Cited by 34 · see citing works
Xia, T., Mao, X., Zhang, J., Rahimnejad, S., & Lu, K. (2024) · Aquaculture · doi:10.1016/j.aquaculture.2023.740538 · Cited by 31 · see citing works
Sommerer, Y., Dobričić, V., Schilling, M., Ohlei, O., Sabet, S. S., Wesse, T., Fuß, J., Franzenburg, S., Franke, A., Parkkinen, L., et al. (2023) · Alzheimer s Research & Therapy · doi:10.1186/s13195-023-01232-7 · Cited by 30 · see citing works
Liu, Y., Long, H., Feng, S.-M., Ma, T., Wang, M.-F., Niu, L., Zhang, X.-Y., Wang, L.-N., Lei, Y., Chen, Y.-L., et al. (2021) · BMC Genomics · doi:10.1186/s12864-021-08141-9 · Cited by 22 · see citing works
Song, Y., Cai, Q., Wang, S., Li, L., Wang, Y., Zou, S., Gao, X., & Wei, Y. (2022) · Nutrients · doi:10.3390/nu14235066 · Cited by 29 · see citing works
Karis, P., Jaakson, H., Ling, K., Bruckmaier, R. M., Gross, J. J., Pärn, P., Kaart, T., & Ots, M. (2020) · Journal of Dairy Science · doi:10.3168/jds.2019-17373 · Cited by 28 · see citing works
Liu, X., Yang, Z., Li, H., Luo, W., Duan, W., Zhang, J., Zhu, Z., Liu, M., Li, S., Xin, X., et al. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/7374086 · Cited by 28 · see citing works
Sharma, A., Maurya, C. K., Arha, D., Rai, A. K., Singh, S., Varshney, S., Schertzer, J. D., & Tamrakar, A. K. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.10.036 · Cited by 28 · see citing works
Eitan, A., Gover, O., Sulimani, L., Meiri, D., & Schwartz, B. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241813797 · Cited by 28 · see citing works
Hirata, B. K. S., Pedroso, A. P., Machado, M. M. F., Neto, N. I. P., Perestrelo, B. D. O., de Sá, R. D. C. C., Alonso‐Vale, M. I. C., Nogueira, F. N., Oyama, L. M., Ribeiro, E. B., et al. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00686 · Cited by 27 · see citing works
Self-citationBarbouche, R., Gaigé, S., Airault, C., Poirot, K., Dallaporta, M., Troadec, J., & Abysique, A. (2020) · Scientific Reports · doi:10.1038/s41598-020-68712-w · Cited by 27 · see citing works
Mammalian lipid droplets: structural, pathological, immunological and anti-toxicological roles
Hammoudeh, N., Soukkarieh, C., Murphy, D. J., & Hanano, A. (2023) · Progress in Lipid Research · doi:10.1016/j.plipres.2023.101233 · Cited by 27 · see citing works
Combination therapy with catechins and caffeine inhibits fat accumulation in 3T3-L1 cells
Zhu, X., Yang, L., Xu, F., Lin, L., & Zheng, G. (2016) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2016.3975 · Cited by 27 · see citing works
Microfluidic systems for studying dynamic function of adipocytes and adipose tissue
Li, X., & Easley, C. J. (2017) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-017-0741-8 · Cited by 26 · see citing works
PM2.5 exposure induces age-dependent hepatic lipid metabolism disorder in female mice
Yan, R., Ku, T., Yue, H., Li, G., & Sang, N. (2019) · Journal of Environmental Sciences · doi:10.1016/j.jes.2019.10.014 · Cited by 26 · see citing works
The Impact of Excessive Fructose Intake on Adipose Tissue and the Development of Childhood Obesity
Azevedo‐Martins, A. K., Santos, M. P., Abayomi, J. C., Ferreira, N. J. R., & Evangelista, F. S. (2024) · Nutrients · doi:10.3390/nu16070939 · Cited by 27 · see citing works
Chen, M., Bai, M., Yi, Y., Lu, S., Luo, J. F., Li, P., Zhang, H., Jiang, H., & Zhou, H. (2022) · Toxicology Letters · doi:10.1016/j.toxlet.2022.05.003 · Cited by 23 · see citing works
Voss, T. S., Vendelbo, M. H., Kampmann, U., Pedersen, S. B., Nielsen, T. S., Johannsen, M., Svart, M. V., Jessen, N., & Møller, N. (2016) · Diabetologia · doi:10.1007/s00125-016-4126-x · Cited by 23 · see citing works
Genetically modified mouse models to study hepatic neutral lipid mobilization
Haemmerle, G., & Lass, A. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.06.001 · Cited by 23 · see citing works
Chiu, Y., Tu, H.-H., Kung, M., Wu, H.-J., & Chen, Y. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111848 · Cited by 22 · see citing works
Li, Z., Zhang, G., Pan, K., Niu, X., Shu‐Chien, A. C., Chen, T., Zhang, X., & Wu, X. (2023) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2023.111474 · Cited by 21 · see citing works
Aveseh, M., Jahromi, M. K., Nemati, J., & Esmaeili‐Mahani, S. (2018) · Endocrine · doi:10.1007/s12020-018-1640-2 · Cited by 21 · see citing works
Molecular Regulation of Thermogenic Mechanisms in Beige Adipocytes
Yang, S., Liu, Y., Wu, X., Zhu, R., Sun, Y., Zou, S., Zhang, D., & Yang, X. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126303 · Cited by 20 · see citing works
Luo, T. F., Miranda-Garcia, O., Sasaki, G., & Shay, N. F. (2017) · Food & Function · doi:10.1039/c7fo00702g · Cited by 19 · see citing works
Doherty, A. H., Roteliuk, D. M., Gookin, S. E., McGrew, A. K., Broccardo, C. J., Condon, K. W., Prenni, J. E., Wojda, S. J., Florant, G. L., & Donahue, S. W. (2016) · Physiological and Biochemical Zoology · doi:10.1086/687413 · Cited by 19 · see citing works
Lee, H. J., Lee, M., Lee, S. G., Yeo, U. C., & Chang, S. E. (2016) · Lasers in Surgery and Medicine · doi:10.1002/lsm.22576 · Cited by 19 · see citing works
Nutrient metabolism of the nucleus pulposus: A literature review
Kodama, J., Wilkinson, K. J., & Otsuru, S. (2022) · North American Spine Society Journal (NASSJ) · doi:10.1016/j.xnsj.2022.100191 · Cited by 18 · see citing works
Reprogramming of glucocorticoid receptor function by hypoxia
Vanderhaeghen, T., Timmermans, S., Watts, D., Paakinaho, V., Eggermont, M., Vandewalle, J., Wallaeys, C., Wyngene, L. V., Looveren, K. V., Nuyttens, L., et al. (2021) · EMBO Reports · doi:10.15252/embr.202153083 · Cited by 17 · see citing works
Chen, S., Zhang, W., Sun, C., Song, M., Liu, S., Xu, M., Zhang, X., Liu, L., & Liu, C. (2020) · Advanced Science · doi:10.1002/advs.202000542 · Cited by 17 · see citing works
Chumphoochai, K., Chalorak, P., Suphamungmee, W., Sobhon, P., & Meemon, K. (2019) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.9646 · Cited by 18 · see citing works
Huang, M., Lin, Y., Wang, L., You, X., Wang, S., Zhao, J., Bai, M., Li, Z., & Chen, Y. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101182 · Cited by 17 · see citing works
Zymography for Picogram Detection of Lipase and Esterase Activities
Ng, A. M. J., Zhang, H., & Nguyen, G. K. T. (2021) · Molecules · doi:10.3390/molecules26061542 · Cited by 17 · see citing works
Jin, H., Oh, H., Nah, S.-Y., & Lee, B.-Y. (2021) · Journal of Ginseng Research · doi:10.1016/j.jgr.2021.10.003 · Cited by 17 · see citing works
Dong, J., Yue, K., Loor, J. J., Aboragah, A. A., Li, G., Chen, L., Song, Y., Du, X., Liu, G., Wang, Z., et al. (2022) · Journal of Dairy Science · doi:10.3168/jds.2021-20445 · Cited by 17 · see citing works
Rahman, M. S., Imran, K. M., Hossain, M., Lee, T., & Kim, Y. (2020) · Phytotherapy Research · doi:10.1002/ptr.6845 · Cited by 17 · see citing works
Bełtowski, J., & Wiórkowski, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031346 · Cited by 16 · see citing works
Physcion reduces lipid accumulation and prevents the obesity in mice
Lee, S.-J., Cho, S.-J., Kwon, E., & Choi, M. (2019) · Nutrition & Metabolism · doi:10.1186/s12986-019-0362-7 · Cited by 16 · see citing works
Liu, S., Wang, X., Li, Y., Shi, B., Guo, X., Zhao, Y., & Yan, S. (2021) · Animals · doi:10.3390/ani11030790 · Cited by 16 · see citing works
Biasiotto, G., Zanella, I., Predolini, F., Archetti, I., Cadei, M., Monti, E., Luzzani, M., Pacchetti, B., Mozzoni, P., Andreoli, R., et al. (2018) · British Journal Of Nutrition · doi:10.1017/s0007114518001824 · Cited by 16 · see citing works
Bonilla-Carvajal, K., Stashenko, E. E., & Moreno‐Castellanos, N. (2022) · Current Issues in Molecular Biology · doi:10.3390/cimb44110389 · Cited by 15 · see citing works
Weng, G., Huang, J., Ma, X., Song, M. S., Yin, Y., Deng, D., & Deng, J. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1050025 · Cited by 15 · see citing works
Li, M., Wang, M., Liu, Y., Huang, S., Yi, X., Yin, C., Wang, S., Zhang, M., Yu, Q., Li, P., et al. (2019) · Obesity · doi:10.1002/oby.22434 · Cited by 16 · see citing works
Cho, S. Y., Lim, S., Ahn, K. S., Kwak, H. J., Park, J., & Um, J. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105312 · Cited by 15 · see citing works
Jin, H., Oh, H., Kim, J., Lee, K., Han, X., Lee, O., & Lee, B.-Y. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104511 · Cited by 15 · see citing works
Aiassa, V., Ferreira, M. D. R., Villafañe, N., & D’Alessandro, M. E. (2022) · Food Research International · doi:10.1016/j.foodres.2022.111164 · Cited by 15 · see citing works
Sharma, B. R., Kim, D. W., & Rhyu, D. Y. (2017) · Journal of Chinese Integrative Medicine · doi:10.1016/s2095-4964(17)60321-2 · Cited by 14 · see citing works
Effect of Resistance Exercise on the Lipolysis Pathway in Obese Pre- and Postmenopausal Women
Kang, S., Park, K.-M., Sung, K.-Y., Yuan, Y., & Lim, S. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11090874 · Cited by 14 · see citing works
Standardized Hydrangea serrata (Thunb.) Ser. Extract Ameliorates Obesity in db/db Mice
Han, H.-S., Chung, K., Shin, Y., Lee, S. H., & Lee, K. (2021) · Nutrients · doi:10.3390/nu13103624 · Cited by 13 · see citing works
Levine, J. A., Sarrafan‐Chaharsoughi, Z., Patel, T. P., Brady, S. M., Chivukula, K. K., Miller, E. K., Han, J. M., Periwal, V., Wolska, A. T., Remaley, A. T., et al. (2022) · Obesity · doi:10.1002/oby.23341 · Cited by 13 · see citing works
Abdisa, K. B., Szerdahelyi, E., Molnár, M. A., Friedrich, L. F., Lakner, Z., Koris, A. K., Tóth, A., & Nath, A. (2024) · Biomolecules · doi:10.3390/biom14040478 · Cited by 15 · see citing works
Garza, V. A. A. (2025) · Impact Research Journal · doi:10.63380/irj.v3n2.2025.195 · Cited by 13 · see citing works
Dai, Y., Liu, W., Li, X., Zhou, M., Xu, C., Qian, Y., & Jiang, G. (2018) · Fish Physiology and Biochemistry · doi:10.1007/s10695-018-0502-4 · Cited by 13 · see citing works
Chen, S., Zhang, W., Sun, C., Song, M., Liu, S., Xu, M., Zhang, X., Liu, L., & Liu, C. (2021) · Advanced Science · doi:10.1002/advs.202101789 · Cited by 12 · see citing works
Liu, M., Zhang, J. F., Zhu, W. L., Liu, H., & Jia, X. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.09.096 · Cited by 13 · see citing works
Gao, Q., Luo, Z., Ma, S., Yu, C., Shen, C. X., Xu, W., Zhang, J., Zhang, H., & Xu, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043269 · Cited by 12 · see citing works
Garza, V. A. A. (2025) · Nexus Research Journal. · doi:10.62943/nrj.v4n2.2025.379 · Cited by 12 · see citing works
Lei, C. X., Tian, J. J., Ji, H., & Yang, L. (2018) · Journal of Fish Biology · doi:10.1111/jfb.13743 · Cited by 12 · see citing works
Das, S., Sakr, H. F., Sirasanagandla, S. R., Bima, A. I. H., & Elsamanoudy, A. Z. (2022) · Current Diabetes Reviews · doi:10.2174/1573399818666220511121629 · Cited by 13 · see citing works
Alternative Methods as Tools for Obesity Research: In Vitro and In Silico Approaches
Pamplona, J. H., Zoehler, B., Shigunov, P., Barisón, M. J., Severo, V. R., Erich, N. M., Ribeiro, A. L., Horinouchi, C. D. D. S., Suzukawa, A. A., Robert, A. W., et al. (2022) · Life · doi:10.3390/life13010108 · Cited by 12 · see citing works
Sun, J. H., Zhou, Y., Shi, X., Ji, H., Du, Z., & Chen, L. (2017) · Gene · doi:10.1016/j.gene.2017.10.040 · Cited by 12 · see citing works
Daddam, J. R., Hammon, H. M., Tröscher, A., Vogel, L. A., Gnott, M., Kra, G., Levin, Y., Sauerwein, H., & Zachut, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063227 · Cited by 12 · see citing works
Yan, Z., Zhong, Y., Yin, Y., Duan, Y., Wang, W., Zhang, L., Guo, Q., Chen, Q., & Li, F. (2021) · Animals · doi:10.3390/ani11113225 · Cited by 11 · see citing works
Dahabiyeh, L. A., Bustanji, Y. K., & Taha, M. O. (2018) · Chemical Biology & Drug Design · doi:10.1111/cbdd.13463 · Cited by 11 · see citing works
Tissue fibrosis associated depletion of lipid‐filled cells
Jussila, A. R., Zhang, B., Kirti, S., & Atit, R. P. (2024) · Experimental Dermatology · doi:10.1111/exd.15054 · Cited by 10 · see citing works
Wang, D., Zhang, M., Zhang, Y., Yin, Z., Zhang, S., Zhao, Z., & Duan, Y. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.140444 · Cited by 10 · see citing works
Bone Marrow Niche Aging: Are Adipocytes Detrimental Cells in the Bone Marrow?
Švajger, U., Milić, P., & Rožman, P. (2025) · Cells · doi:10.3390/cells14110814 · Cited by 10 · see citing works
Garza, V. A. A. (2025) · Revista Científica Kosmos. · doi:10.62943/rck.v4n2.2025.381 · Cited by 10 · see citing works
- Authors
- Bolsoni-Lopes, A., & Alonso-Vale, M. I. C.
- Affiliations
- Universidade de São Paulo, Brazil
- Universidade Federal de São Paulo, Brazil
- Venue
- Archives of Endocrinology and Metabolism
- Published
- 2015-08
- Volume
- 59
- Issue
- 4
- Pages
- 335-342
- ISSN
- 2359-3997 (ISSN-L)
- OpenAlex
- W2200889199
- Cited by
- 183
- References
- 69
- Citations by year
- 2026: 8 · 2025: 16 · 2024: 16 · 2023: 10 · 2022: 29 · 2021: 33 · 2020: 24 · 2019: 17 · 2018: 16 · 2017: 7 · 2016: 7
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc
- Locations
- Archives of Endocrinology and Metabolism (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, cc-by-nc)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- lipolysis, white adipose tissue, adipocytes, hormone-sensitive lipase, monoacylglycerol lipase, adipose triglyceride lipase, lipid droplets, metabolic homeostasis
- MeSH terms
- Humans, Lipase, Lipolysis, Adipose Tissue, White
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