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Effect of ethyl acetate extract from husk fiber water of Cocos nucifera in Leishmania braziliensis infected hamsters
Open accessAbstract
The objective of this study was to evaluate the treatment with ethyl acetate extract (EAE) from husk fiber water of Cocos nucifera L., Arecaceae, in L. braziliensis (Lb) infected hamsters. Twelve male hamsters were randomly allocated in three groups (n=4): G1 received only EAE; G2 was infected with Lb only and G3 received EAE after Lb infection. The infection was carried 28 days prior to the treatment with EAE, which was administrated (0.2 mL, 300 mg.kg-1) for 21 consecutive days. Infection was evaluated through skin lesions and infected footpad edema. Haematological evaluation was done on -28th, 0 and 21st days. Imprint footpad and lymph node weight were evaluated on 21st day. Lb infection significantly inhibited the peripheral leukocytes blood. However, neutrophils and lymphocytes values did not have significant alterations. G3 presented eosinophilia in relation to G2. The treatment with EAE did not reduce edema of infected footpad neither weight of drainage lymph node. Infected footpad imprints revealed amastigotes forms and cellular infiltration. Animals from G3 presented skin lesions on 7th day, shown a reduction of these lesions in day 14. Therefore, the treatment with EAE did not alter the etiological agent elimination in these conditions. However, EAE presents a healing activity in this experimental model.
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“The lyophilized extract and fractions, as well as ethyl acetate extracts, from the C. nucifera fiber are rich in polyphenols, compounds such as catechins, epicatechins, tannins, and flavonoids (7,33–35).”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [35]
In the citing paper
“Administering EAE (0.2 mL, 300 mg/kg) for 21 consecutive days did not reduce edema of infected footpad nor the weight of lymph node drainage but reduced skin lesions after 14 days.”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [35]
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Inhibitory activity of limonene against Leishmania parasites in vitro and in vivo
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Evaluation of the leishmanicidal activity of plants used by Peruvian Chayahuita ethnic group
Estevez, Y., Castillo, D., Tangoa, M. P., Arévalo, J., Rojas, R., Castillo, J. A., Deharo, E., Bourdy, G., & Sauvain, M. (2007) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2007.08.007 · Cited by 99
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Simões-Mattos, L., Mattos, M. R. F., Teixeira, M. J., Oliveira-Lima, J. W., Bevilaqua, C. M. L., Prata-Júnior, R. C., Holanda, C. M. D. C. X., Rondon, F. C. M., Bastos, K. M. S., Coêlho, Z. C. B., et al. (2004) · Veterinary Parasitology · doi:10.1016/j.vetpar.2004.10.008 · Cited by 54
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Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review
Lima, E. B. C., Sousa, C. N. S., Meneses, L. N., Ximenes, N. C., Santos Júnior, M. A., Vasconcelos, G. S., Lima, N. B. C., Patrocínio, M. C. A., Macedo, D., & Vasconcelos, S. M. M. (2015) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20154773 · Cited by 295
Roopan, S. M. (2016) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-016-2067-y · Cited by 53
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Metadata
- Authors
- Freitas, J. C. C., Nunes-Pinheiro, D. C. S., Pessoa, A. W. P., Silva, L. C. R., Girão, V. C. C., Lopes-Neto, B. E., Agostinho, M. S., & Abreu, C. R. A.
- Affiliations
- Universidade Estadual do Ceará (BR)
- Venue
- Revista Brasileira de Farmacognosia
- Published
- 2011-12
- Volume
- 21
- Issue
- 6
- Pages
- 1006-1011
- ISSN
- 0102-695X (ISSN-L)
- OpenAlex
- W1569289873
- Cited by
- 14
- References
- 12
- Citations by year
- 2023: 2 · 2022: 4 · 2021: 1 · 2020: 3 · 2018: 1 · 2016: 1 · 2015: 1 · 2013: 1
- FWCI
- 0.31
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Revista Brasileira de Farmacognosia (publishedVersion, cc-by-nc-nd)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry Medicinal Plant Applications
- Life Sciences › Agricultural and Biological Sciences › Food Science › Coconut Research and Applications
- Keywords
- Cocos nucifera, ethyl acetate extract, Leishmania braziliensis, cutaneous leishmaniasis, antileishmanial activity, wound healing, skin lesions, eosinophilia, peripheral blood leukocytes, lymph node weight, amastigotes, hamster model
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- CoChat. (2026). Citation check: Effect of ethyl acetate extract from husk fiber water of Cocos nucifera in Leishmania braziliensis infected hamsters. https://app.cochat.ai/papers/10.1590/s0102-695x2011005000138
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- Freitas, J. C. C., Nunes-Pinheiro, D. C. S., Pessoa, A. W. P., Silva, L. C. R., Girão, V. C. C., Lopes-Neto, B. E., Agostinho, M. S., & Abreu, C. R. A. (2011). Effect of ethyl acetate extract from husk fiber water of Cocos nucifera in Leishmania braziliensis infected hamsters. Revista Brasileira de Farmacognosia. https://doi.org/10.1590/s0102-695x2011005000138
