Structure versus anticoagulant and antithrombotic actions of marine sulfated polysaccharides
Open accessAbstract
Marine sulfated polysaccharides (MSP), such as sulfated fucans (SF), sulfated galactans (SG) and glycosaminoglycans (GAG) isolated from either algae or invertebrate animals, are highly anionic polysaccharides capable of interacting with certain cationic proteins, such as (co)-factors of the coagulation cascade during clotting-inhibition processes. These molecular complexes between MSP and coagulation-related proteins might, at first glance, be assumed to be driven mostly by electrostatic interactions. However, a systematic comparison using several novel sulfated polysaccharides composed of repetitive oligosaccharides with clear sulfation patterns has shown that these molecular interactions are regulated essentially by the stereochemistry of the glycans (which depends on a conjunction of anomericity, monosaccharide, conformational preference, and glycosylation and sulfation sites), rather than just a simple consequence of their negative charge density (mainly the number of sulfate groups). Here, we present an overview of the structure-function relationships of MSP, correlating their structures with their potential anticoagulant and antithrombotic actions, since pathologies related to the cardiovascular system are one of the major causes of illness and mortality in the world.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Polysaccharides from marine animals demonstrate diverse biological properties, including anticoagulant, antithrombotic, antioxidative, neuroprotective, and antiviral activity.
“These compounds demonstrate diverse biological properties, including anticoagulant and antitrombotic [131,132,133], antioxidative [134], neuroprotective [135,136], and antiviral activity as well [8,137].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [131]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Structure of Glycosaminoglycans and their Interactions with Proteins
Gandhi, N. S., & Mancera, R. L. (2008) · Chemical Biology & Drug Design · doi:10.1111/j.1747-0285.2008.00741.x · Cited by 1,038 · see citing works
Berteau, O. (2003) · Glycobiology · doi:10.1093/glycob/cwg058 · Cited by 769 · see citing works
Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events
Guerrini, M., Beccati, D., Shriver, Z. H., Naggi, A., Viswanathan, K., Bisio, A., Capila, I., Lansing, J. C., Guglieri, S., Fraser, B. A., et al. (2008) · Nature Biotechnology · doi:10.1038/nbt1407 · Cited by 631 · see citing works
Contaminated Heparin Associated with Adverse Clinical Events and Activation of the Contact System
Kishimoto, T., Viswanathan, K., Ganguly, T. C., Elankumaran, S., Smith, S., Pelzer, K. D., Lansing, J. C., Sriranganathan, N., Zhao, G., Galcheva-Gargova, Z., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0803200 · Cited by 622 · see citing works
Structure and Anticoagulant Activity of Sulfated Fucans
Pereira, M. S., Mulloy, B., & Mourão, P. A. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.12.7656 · Cited by 377 · see citing works
Self-citationStructure and Anticoagulant Activity of Sulfated Galactans
Farias, W. R. L., Valente, A. P., Pereira, M. S., & Mourão, P. A. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002422200 · Cited by 369 · see citing works
Self-citationStructure, biology, evolution, and medical importance of sulfated fucans and galactans
Pomin, V. H., & Mourao, P. A. S. (2008) · Glycobiology · doi:10.1093/glycob/cwn085 · Cited by 356 · see citing works
Self-citationUse of Sulfated Fucans as Anticoagulant and Antithrombotic Agents: Future Perspectives
Mourao, P. (2004) · Current Pharmaceutical Design · doi:10.2174/1381612043452730 · Cited by 195 · see citing works
Self-citationHighly Sulfated Dermatan Sulfates from Ascidians
Pavão, M. S. G., Aiello, K. R. M., WERNECK, C. C., Silva, L. C. F., Valente, A. P., Mulloy, B., Colwell, N. S., Tollefsen, D. M., & Mourão, P. A. S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.43.27848 · Cited by 187 · see citing works
Self-citationPereira, M. G., Benevídes, N. M. B., Melo, M. R. S., Valente, A. P., Melo, F. R., & Mourão, P. A. S. (2005) · Carbohydrate Research · doi:10.1016/j.carres.2005.05.018 · Cited by 181 · see citing works
Self-citationMulloy, B., Ribeiro, A.-C., Alves, A.-P., Vieira, R. P., & Mourão, P. A. S. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31763-5 · Cited by 175 · see citing works
Self-citationAlves, A.-P., Mulloy, B., Diniz, J. A., & Mourão, P. A. S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.11.6965 · Cited by 175 · see citing works
Self-citationPereira, M. S., Melo, F. R., & Mourao, P. A. S. (2002) · Glycobiology · doi:10.1093/glycob/cwf077 · Cited by 175 · see citing works
Self-citationAnalysis of the inhibition of tumour metastasis by sulphated polysaccharides
Coombe, D. R., Parish, C. R., Ramshaw, I. A., & Snowden, J. M. (1987) · International Journal of Cancer · doi:10.1002/ijc.2910390115 · Cited by 174 · see citing works
Searching for Alternatives to Heparin Sulfated Fucans from Marine Invertebrates
Mourão, P. (1999) · Trends in Cardiovascular Medicine · doi:10.1016/s1050-1738(00)00032-3 · Cited by 174 · see citing works
Self-citationAntithrombin-mediated Anticoagulant Activity of Sulfated Polysaccharides
Melo, F. R., Pereira, M. S., Foguel, D., & Mourão, P. A. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m308688200 · Cited by 158 · see citing works
Self-citationAn Update on Heparins at the Beginning of the New Millennium
Fareed, J., Hoppensteadt, D. A., & Bick, R. L. (2000) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-2000-9498 · Cited by 137 · see citing works
A Unique Dermatan Sulfate-like Glycosaminoglycan from Ascidian:
Pavão, M. S. G., Mourão, P. A. S., Mulloy, B., & Tollefsen, D. M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.52.31027 · Cited by 131 · see citing works
Self-citationVilela-Silva, A.-C. E. S., Castro, M. O., Valente, A. P., Biermann, C. H., & Mourão, P. A. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108496200 · Cited by 116 · see citing works
Self-citationPomin, V. H. (2009) · Biopolymers · doi:10.1002/bip.21200 · Cited by 115 · see citing works
Self-citationStructural and functional insights into sulfated galactans: a systematic review
Pomin, V. H. (2009) · Glycoconjugate Journal · doi:10.1007/s10719-009-9251-z · Cited by 114 · see citing works
Self-citationFonseca, R. J. C., Oliveira, S.-N., Melo, F., Pereira, M. G., Benevídes, N. M. B., & Mourão, P. A. D. S. (2008) · Thrombosis and Haemostasis · doi:10.1160/th07-10-0603 · Cited by 112 · see citing works
Self-citationVilela-Silva, A. C. E. S., Alves, A.-P., Valente, A. P., Vacquier, V. D., & Mourão, P. A. S. (1999) · Glycobiology · doi:10.1093/glycob/9.9.927 · Cited by 109 · see citing works
Self-citationAlves, A.-P., Mulloy, B., Moy, G. W., Vacquier, V. D., & Mourão, P. A. S. (1998) · Glycobiology · doi:10.1093/glycob/8.9.939 · Cited by 83 · see citing works
Self-citationA 2-sulfated, 3-linked α-l-galactan is an anticoagulant polysaccharide
Pereira, M. S., Vilela-Silva, A.-C. E. S., Valente, A.-P., & Mourão, P. A. S. (2002) · Carbohydrate Research · doi:10.1016/s0008-6215(02)00215-x · Cited by 77 · see citing works
Self-citationMourão, P. A. D. S., & Perlin, A. S. (1987) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1987.tb13534.x · Cited by 77 · see citing works
Self-citationStructural diversity among sulfated α‐L‐galactans from ascidians (tunicates)
Santos, J. A., Mulloy, B., & Mourão, P. A. S. (1992) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1992.tb16680.x · Cited by 70 · see citing works
Self-citationVilela-Silva, A.-C. E. S., Hirohashi, N., & Mour�o, P. A. S. (2008) · The International Journal of Developmental Biology · doi:10.1387/ijdb.072531av · Cited by 57 · see citing works
Self-citationA carbohydrate-based mechanism of species recognition in sea urchin fertilization
Mourão, P. A. S. (2007) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2007000100002 · Cited by 55 · see citing works
Self-citationBecker, C. F., Guimarães, J. A., Mourão, P. A. S., & Verli, H. (2007) · Journal of Molecular Graphics and Modelling · doi:10.1016/j.jmgm.2007.01.008 · Cited by 51 · see citing works
Self-citationA Unique 2-Sulfated β-Galactan from the Egg Jelly of the Sea Urchin Glyptocidaris crenularis
Castro, M. O., Pomin, V. H., Santos, L. L. D., Vilela-Silva, A.-C. E. S., Hirohashi, N., Fachin, L. P., Verli, H., & Mourão, P. A. S. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.005702 · Cited by 51 · see citing works
Self-citationVicente, C. P., Zancan, P., Peixoto, L. L., Alves-Sá, R., Araújo, F. S., Mourão, P. A. S., & Pavão, M. S. G. (2001) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1616054 · Cited by 41 · see citing works
Self-citationStructure and anticoagulant properties of sulfated glycosaminoglycans from primitive Chordates
Pavão, M. S. G. (2002) · Anais da Academia Brasileira de Ciências · doi:10.1590/s0001-37652002000100007 · Cited by 23 · see citing works
Sulphated polysaccharides exert anti-HIV activity at differing sites
Harrop, H. A., Rider, C. C., & Coombe, D. R. (1992) · Biochemical Society Transactions · doi:10.1042/bst020163s · Cited by 15 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects
Fedorov, S., Ermakova, S., Zvyagintseva, T., & Stonik, V. (2013) · Marine Drugs · doi:10.3390/md11124876 · Cited by 189 · see citing works
Antithrombotics from the Sea: Polysaccharides and Beyond
Carvalhal, F., Cristelo, R. R., Resende, D. I. S. P., Pinto, M. M. M., Sousa, E., & Correia‐da‐Silva, M. (2019) · Marine Drugs · doi:10.3390/md17030170 · Cited by 74 · see citing works
Pomin, V. H., & Mourão, P. A. S. (2014) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2014.00033 · Cited by 52 · see citing works
Self-citationZhang, W., Wang, J., Jin, W., & Zhang, Q. (2013) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2013.02.035 · Cited by 40 · see citing works
de Carvalho, M. M., Noseda, M. D., Dallagnol, J. C. C., Ferreira, L. G., Ducatti, D. R. B., Gonçalves, A. G., de Freitas, R. A., & Duarte, M. E. R. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.06.146 · Cited by 37 · see citing works
Ktari, L., Ajjabi, L. C., Clerck, O. D., Gómez‐Pinchetti, J. L., & Rebours, C. (2021) · Journal of Applied Phycology · doi:10.1007/s10811-021-02579-w · Cited by 37 · see citing works
Kravchenko, A. O., Anastyuk, S. D., Isakov, V. V., Sokolova, E. V., Glazunov, V. P., & Yermak, I. M. (2014) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2014.04.022 · Cited by 30 · see citing works
Pomin, V. H. (2014) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2014.00005 · Cited by 29 · see citing works
Self-citationSilchenko, A. S., Taran, I. V., Usoltseva, R. V., Zvyagintsev, N. V., Zueva, A. O., Rubtsov, N. K., Lembikova, D. E., Nedashkovskaya, O. I., Игоревич, К. М., Isaeva, M. P., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010218 · Cited by 22 · see citing works
Román-Ochoa, Y., Iacomini, M., Sassaki, G. L., & Cipriani, T. R. (2016) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2016.03.061 · Cited by 22 · see citing works
de Sousa, A. K., Araújo, A. S. M. L., da Silva, T. M. L., de Lima, F. M. D. S., Ferreira, J. D. S., de Brito, T. V., & Barbosa, A. L. D. R. (2022) · Journal of Applied Phycology · doi:10.1007/s10811-022-02878-w · Cited by 10 · see citing works
Radical scavenging activities of Asterina pectinifera fermented with Cordyceps militaris mycelia
Kim, Y.-S., Kim, E., Natarajan, S. B., Hwang, J.-W., Kim, S.-E., Jeon, N.-J., Lee, J. W., Jeong, J.-H., Kim, H., & Park, P. (2016) · Food Science and Biotechnology · doi:10.1007/s10068-016-0104-9 · Cited by 4 · see citing works
Obino, G., Lepedda, A. J., & Moroni, L. (2026) · Materials Horizons · doi:10.1039/d6mh00404k · Cited by 1 · see citing works
Evaluation of the Pharmacological Activities of a Xylan from Corn Cobs
Nobrega, R. L. T., Viana, R. L. S., Silva, M. B., da Matta, L. D. M., Souza, G. P. V. A., Rocha, H. A. O., & Melo‐Silveira, R. F. (2025) · Polysaccharides · doi:10.3390/polysaccharides6010009 · Cited by 1 · see citing works
XILANAS DE SABUGO DE MILHO COMO AGENTE ANTIOXIDANTE, CITOTÓXICO, ANTICOAGULANTE E IMUNOMODULADOR
Silveira, R. F. D. M. (2014) · Americanae (AECID Library)
Marine Biopharmaceuticals – A Retrospective of Molecular Mechanisms
Ghori, S. T., Kamali, V., Muralitharan, U., Maikkara, A., & Mahesh, A. (2020) · Wiley eBooks · doi:10.1002/9781119143802.ch122
BENEFÍCIOS DAS PLANTAS MEDICINAIS NO TRATAMENTO DA ANSIEDADE E DEPRESSÃO
da Silva, S. T., & Silva, J. E. D. S. (2021) · doi:10.22533/at.ed.4292129074
Vieira, C. M. D., dos Santos, H. A. M., Vieira, A. C. D. M., & Guimarães, A. L. D. A. (2021) · doi:10.22533/at.ed.42921290711
ANSIOLÍTICOS FITOTERÁPICOS COMO ADJUVANTES NO TRATAMENTO DA ANSIEDADE: UMA REVISÃO SISTEMÁTICA
Silva, Í. R. J. E., Júnior, D. A. L., Giló, L. A., Machado, P. P. L., Marques, T. B. D., & Pereira, J. L. (2021) · doi:10.22533/at.ed.4292129073
ISOLAMENTO E ATIVIDADE ANTICOAGULANTE DE POLISSACARÍDEOS SULFATADOS DE MACROALGAS MARINHAS VERMELHAS
Nogueira, J. D. L. F., da Costa, B. B., Moreira, T. A., Gianelli, J. L. D., & Cinelli, L. P. (2021) · doi:10.22533/at.ed.4292129075
MEDICAMENTOS À BASE DE CANABIDIOL NO BRASIL: UMA REVISÃO DE LITERATURA
Pereira, L. D. S., & de Oliveira, F. G. (2021) · doi:10.22533/at.ed.42921290715
França, B. V., & de Miranda, C. V. (2021) · doi:10.22533/at.ed.4292129077
ATIVIDADES BIOATIVAS PRESENTES NO ALECRIM (Rosmarinus officinalis)
Silva, E. R. S., da Silva, J. F., & Guedes, J. P. D. M. (2021) · doi:10.22533/at.ed.4292129072
EXTRAÇÃO DE CORANTES NATURAIS: PROPOSTA DE ENSINO PARA O CLUBE DE CIÊNCIAS E OS JOVENS CIENTISTAS
Miola, G. M. D. V. F., & Scalcon, A. (2021) · doi:10.22533/at.ed.42921290714
SÍNTESE DE NOVOS DERIVADOS HETEROCÍCLICOS ANÁLOGOS DAS CHALCONAS
Alves, T. D. S., Greenwood, S. M. P., Botinhão, M. D. C., Melo, E. D. D. N., Barcelos, R. A. D. S., da Rocha, E. D. A. D. C., do Carmo, P. L., Rodrigues, C. R., & Gomes, A. D. O. (2021) · doi:10.22533/at.ed.4292129076
da Rocha, J. C., & Gonsalez, S. R. (2021) · doi:10.22533/at.ed.4292129078
AVALIAÇÃO DA AÇÃO ANTIBACTERIANA DAS FOLHAS DE Moringa oleifera Lamark IN NATURA E PROCESSADA
Santos, G. D. M., Mori, E., Rodrigues, F. F. G., Alencar, A. C. U., da Silva, J. R. A., Ramalho, M. D., Farias, M. A. M., da Silva, C. G. V., & da Silva, M. D. F. S. (2021) · doi:10.22533/at.ed.42921290713
- Authors
- Pomin, V. H., & Mourão, P. A. D. S.
- Affiliations
- Universidade Federal do Rio de Janeiro (BR)
- ORCID
- Pomin, Vitor Hugo
- Venue
- Revista Brasileira de Farmacognosia
- Published
- 2012-08
- Volume
- 22
- Issue
- 4
- Pages
- 921-928
- ISSN
- 0102-695X (ISSN-L)
- OpenAlex
- W1824540854
- Cited by
- 26
- References
- 34
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 1 · 2021: 12 · 2020: 2 · 2019: 1 · 2016: 2 · 2014: 4 · 2013: 2
- FWCI
- 2.82
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Revista Brasileira de Farmacognosia (publishedVersion, cc-by-nc-nd)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Keywords
- sulfated fucans, sulfated galactans, glycosaminoglycans, anticoagulant activity, antithrombotic activity, structure-function relationship, glycosylation sites, coagulation cascade, electrostatic interactions, cardiovascular disease, algae
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
