The antioxidant activities and neuroprotective effect of polysaccharides from the starfish Asterias rollestoni
Abstract
After the starfish was defatted with isopropyl alcohol and ethanol, crude polysaccharide was extracted by 0.15 mol/L HCl. Anion exchange chromatography was performed to fractionate the sample into two fractions, SF-1 and SF-2. Chemical analysis showed that the major component of SF-1 was a glucan consisting of a backbone of 1→3 linked β-D-glucopyranose residues, and it had a minor glucan component containing a backbone of 1→3 linked α-D-glucopyranose residues. SF-2 was a mannoglucan sulfate. SF-2 displayed the highest antioxidant activity among the polysaccharides. Moreover, SF-1 and SF-2 exhibited neuroprotective activities in a neurotoxicity model of Parkinson's disease (PD).
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Polysaccharides from marine animals demonstrate diverse biological properties, including anticoagulant, antithrombotic, antioxidative, neuroprotective, and antiviral activity.
“These compounds demonstrate diverse biological properties, including anticoagulant and antitrombotic [131,132,133], antioxidative [134], neuroprotective [135,136], and antiviral activity as well [8,137].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [134]
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- Authors
- Zhang, W., Wang, J., Jin, W., & Zhang, Q.
- Affiliations
- Chinese Academy of Sciences (CN)
- Corresponding author
- Zhang, Quanbin
- Venue
- Carbohydrate Polymers
- Publisher
- Elsevier BV
- Published
- 2013-06
- Volume
- 95
- Issue
- 1
- Pages
- 9-15
- ISSN
- 0144-8617 (ISSN-L)
- OpenAlex
- W1986660375
- Cited by
- 40
- References
- 22
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 3 · 2023: 5 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 6 · 2016: 3 · 2015: 4 · 2014: 1 · 2013: 1
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Carbohydrate Polymers (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ocean Public Welfare Scientific Research Project
- State Oceanic Administration of the People's Republic of China (No. 201005024)
- Doctorial Fund of Shandong Province (No. BS2011YY066)
- Science and Technology Project of Shandong Province (No. 2011GHY11529)
- Science and Technology Program of Applied Basic Research Projects of Qingdao Municipal (NO.12-1-4-8-(3)-jch)
- Prospective Joint Research Projects of Jiangsu Province (No. BY2011189)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Echinoderm biology and ecology
- Keywords
- antioxidant activity, neuroprotection, Parkinson's disease, glucan, anion exchange chromatography, polysaccharide fractionation, neurotoxicity model
- MeSH terms
- Animals, Antioxidants, Cell Survival, Free Radicals, Parkinson Disease, Polysaccharides, Starfish, Oxidopamine, Neuroprotective Agents, Cell Line, Tumor, Rats
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