Comparative effects of mature coconut water (Cocos nucifera) and glibenclamide on some biochemical parameters in alloxan induced diabetic rats
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In the present study, comparative effects of mature coconut water (Cocos nucifera L., Arecaceae) and glibenclamide in alloxan induced diabetic rats were evaluated. Diabetes mellitus was induced in Sprague-Dawly rats using alloxan monohydrate (150 mg kg−1 body weight). Treatment with lyophilized form of mature coconut water and glibenclamide in diabetic rats reduced the blood glucose and glycated hemoglobin along with improvement in plasma insulin level. Elevated levels of liver function enzymes markers like alkaline phosphatase, serum glutamate oxaloacetate transaminase and serum glutamate pyruvate transaminase in diabetic rats were significantly reduced on treatment with mature coconut water. In addition to this, diabetic rats showed altered levels of blood urea, serum creatinine, albumin, albumin/globulin ratio which were significantly improved by treatment with mature coconut water and glibenclamide. Activities of nitric oxide synthase in liver and plasma L-arginine were reduced significantly in alloxan induced diabetic rats while treatment with mature coconut water reversed these changes. The overall results show that mature coconut water has significant beneficial effects in diabetic rats and its effects were comparable to that of glibenclamide, a well known antidiabetic drug.
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Mature coconut water normalized liver enzyme markers and improved blood urea, serum creatinine, and albumin levels in diabetic rats.
“It also normalized liver enzyme markers and improved blood urea, serum creatinine, and albumin levels [142].”
From Nutritional composition and bioactive properties of tropical coconut palm fruit with functional food applications (2025) · cites this paper as [142]
In diabetic rat models, mature coconut water reduced glycated hemoglobin and blood glucose levels while improving plasma insulin concentrations.
“In diabetic rat models, mature coconut water reduced glycated hemoglobin and blood glucose levels while improving plasma insulin concentrations.”
From Nutritional composition and bioactive properties of tropical coconut palm fruit with functional food applications (2025) · cites this paper as [142]
Preetha et al. found that rats fed mature coconut water exhibited higher nitric oxide synthase activity in the liver, increased plasma arginine concentrations, and elevated urinary nitrite levels compared to the L-arginine-treated group.
“The study found that rats fed MCW exhibited higher nitric oxide synthase activity in the liver, increased plasma arginine concentrations, and elevated urinary nitrite levels compared to the L-arginine-treated group.”
From Nutritional composition and bioactive properties of tropical coconut palm fruit with functional food applications (2025) · cites this paper as [156]
The observed L-arginine-mediated effects suggest a potential mechanism for mitigating metabolic alterations in lipids, blood glucose, and coagulation factors through enhanced nitric oxide production.
“The observed L-arginine-mediated effects suggest a potential mechanism for mitigating metabolic alterations in lipids, profiles of blood glucose as well as coagulation factors through enhanced nitric oxide production.”
From Nutritional composition and bioactive properties of tropical coconut palm fruit with functional food applications (2025) · cites this paper as [156]
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- Authors
- Preetha, P. P., Girija Devi, V., & Rajamohan, T.
- Affiliations
- University of Kerala (IN)
- Corresponding author
- Rajamohan, T.
- ORCID
- Preetha, P.P.
- Venue
- Revista Brasileira de Farmacognosia
- Published
- 2013-05
- Volume
- 23
- Issue
- 3
- Pages
- 481-487
- ISSN
- 0102-695X (ISSN-L)
- OpenAlex
- W2151123040
- Cited by
- 39
- References
- 45
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 4 · 2022: 7 · 2021: 7 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 3 · 2013: 1
- FWCI
- 2.10
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Revista Brasileira de Farmacognosia (publishedVersion, cc-by-nc-nd)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Physical Sciences › Chemistry › Inorganic Chemistry › Coconut Research and Applications
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Keywords
- coconut water, Cocos nucifera, glibenclamide, alloxan-induced diabetes, diabetes mellitus, blood glucose, HbA1c, plasma insulin, liver enzymes, nitric oxide synthase, L-arginine, antidiabetic activity, herbal medicine
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