Comparative evaluation of the hypolipidemic effects of coconut water and lovastatin in rats fed fat–cholesterol enriched diet
Abstract
The coconut water presents a series of nutritional and therapeutic properties, being a natural, acid and sterile solution, which contains several biologically active components, l-arginine, ascorbic acid, minerals such as calcium, magnesium and potassium, which have beneficial effects on lipid levels. Recent studies in our laboratory showed that both tender and mature coconut water feeding significantly (P<0.05) reduced hyperlipidemia in cholesterol fed rats [Sandhya, V.G., Rajamohan, T., 2006. Beneficial effects of coconut water feeding on lipid metabolism in cholesterol fed rats. J. Med. Food 9, 400-407]. The current study evaluated the hypolipidemic effect of coconut water (4ml/100g body weight) with a lipid lowering drug, lovastatin (0.1/100g diet) in rats fed fat-cholesterol enriched diet ad libitum for 45 days. Coconut water or lovastatin supplementation lowered the levels of serum total cholesterol, VLDL+LDL cholesterol, triglycerides and increased HDL cholesterol in experimental rats (P<0.05). Coconut water feeding decreased activities of hepatic lipogenic enzymes and increased HMG CoA reductase and lipoprotein lipase activity (P<0.05). Incorporation of radioactive acetate into free and ester cholesterol in the liver were higher in coconut water treated rats. Coconut water supplementation increased hepatic bile acid and fecal bile acids and neutral sterols (P<0.05). Coconut water has lipid lowering effect similar to the drug lovastatin in rats fed fat-cholesterol enriched diet.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The richness of macro- and micro-nutrients in TCW is reported to have hypolipidemic, cardioprotective, and hepatoprotective effects.
“The richness of macro- and micro-nutrients in TCW is reported to have hypolipidemic, cardioprotective, and hepatoprotective effects [51].”
From Research Progress in Coconut Water: A Review of Nutritional Composition, Biological Activities, and Novel Processing Technologies (2025) · cites this paper as [51]
A similar hypolipidemic effect of coconut water and lovostatin was detected in rats fed a fat/cholesterol-enriched diet.
“A similar hypolipidemic effect of coconut water and lovostatin (a lipid-lowering drug) was detected in rats fed a fat/cholesterol-enriched diet [90].”
From Coconut water uses, composition and properties: a review (2012) · cites this paper as [90]
Cited by
Sorted by citations
The Chemical Composition and Biological Properties of Coconut (Cocos nucifera L.) Water
Yong, J. W. H., Ge, L., Ng, Y. F., & Tan, S. N. (2009) · Molecules · doi:10.3390/molecules14125144 · Cited by 753 · see citing works
“In its natural form, it is a refreshing and nutritious beverage which is widely consumed due to its beneficial properties to health, some of which are based on cultural/traditional beliefs [2,5–8,13–15].”
BackgroundCoconut water uses, composition and properties: a review
Prades, A., Dornier, M., Diop, N., & Pain, J.-P. (2012) · Fruits · doi:10.1051/fruits/2012002 · Cited by 284 · see citing works
Preetha, P. P., Girija Devi, V., & Rajamohan, T. (2013) · Revista Brasileira de Farmacognosia · doi:10.1590/s0102-695x2013005000027 · Cited by 39 · see citing works
Self-citationA concise review on oil extraction methods, nutritional and therapeutic role of coconut products
Divya, P. M., Roopa, B. S., Manusha, C., & Balannara, P. (2023) · Journal of Food Science and Technology · doi:10.1007/s13197-022-05352-0 · Cited by 37 · see citing works
Ansari, P., Khan, J. T., Choudhary, S., Reberio, A. D., Kumar, S., Seidel, V., Abdel-Wahab, Y. H. A., & Flatt, P. R. (2024) · doi:10.20944/preprints202408.1739.v1 · Cited by 89 · see citing works
Basak, S., Jha, T., & Chakraborty, S. (2023) · Innovative Food Science & Emerging Technologies · doi:10.1016/j.ifset.2023.103302 · Cited by 21 · see citing works
Preetha, P. P., Devi, V. G., & Rajamohan, T. (2014) · Comparative Clinical Pathology · doi:10.1007/s00580-013-1784-7 · Cited by 17 · see citing works
Self-citationShi, S., Wang, W., Wang, F., Yang, P., Yang, H., He, X., & Liao, X. (2025) · Foods · doi:10.3390/foods14091503 · Cited by 12 · see citing works
Composition, Properties and Reactions of Coconut Water
Rethinam, P., & Krishnakumar, V. (2022) · Coconut Water · doi:10.1007/978-3-031-10713-9_4 · Cited by 9 · see citing works
Thakur, M., Pant, K., & Nanda, V. (2020) · Antioxidants in Vegetables and Nuts - Properties and Health Benefits · doi:10.1007/978-981-15-7470-2_19 · Cited by 5 · see citing works
Jiang, S., Hun, T. G., Chong, K. H., & Nor-Khaizura, M. A. R. (2025) · International Journal of Basic and Applied Sciences · doi:10.14419/s2v9er57
- Authors
- Sandhya, V. G., & Rajamohan, T.
- Affiliations
- University of Kerala (IN)
- Corresponding author
- Rajamohan, T.
- Venue
- Food and Chemical Toxicology
- Publisher
- Elsevier BV
- Published
- 2008-12
- Volume
- 46
- Issue
- 12
- Pages
- 3586-3592
- ISSN
- 0278-6915 (ISSN-L)
- OpenAlex
- W2051197015
- Cited by
- 62
- References
- 0
- Citations by year
- 2025: 4 · 2024: 4 · 2023: 5 · 2022: 7 · 2021: 6 · 2020: 2 · 2019: 1 · 2018: 4 · 2017: 4 · 2016: 5 · 2015: 3 · 2014: 3 · 2013: 4 · 2012: 4
- FWCI
- 1.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food and Chemical Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Inorganic Chemistry › Coconut Research and Applications
- Health Sciences › Medicine › Surgery › Natural Products and Biological Research
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- coconut water, lovastatin, hypolipidemic effect, hyperlipidemia, serum cholesterol, triglycerides, HDL cholesterol, HMG-CoA reductase, lipoprotein lipase, bile acids, fecal bile acids, neutral sterols, cholesterol esterification, lipid metabolism
- MeSH terms
- Acetates, Animals, Hypolipidemic Agents, Bile Acids and Salts, Body Weight, Cholesterol, Cholesterol, Dietary, Cocos, Diet, Dietary Fats, Eating, Feces, Hydroxymethylglutaryl CoA Reductases, Lipids, Lipoproteins, Liver, Liver Function Tests, Lovastatin, Male, Sterols, Rats, Sprague-Dawley, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
