Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 19

The DOI matches its Crossref record.

In vitro minocycline activity on superinfecting microorganisms isolated from chronic periodontitis patients

Oliveira, Luciana Fernandes de, Jorge, Antonio Olavo Cardoso, Santos, Silvana Soléo Ferreira dos·2006·Brazilian Oral Research
DOI 10.1590/s1806-83242006000300004
Open this paper in CoChat — free account

Abstract

Chronic periodontitis is the most common type of periodontitis and it is associated with various species of microorganisms. Enteric rods, Pseudomonas, Staphyloccocus and Candida have been retrieved from periodontal pockets of patients with chronic periodontitis and correlated to cases of superinfection. Local or systemic antibiotic therapy is indicated to reinforce the effects of the conventional mechanical therapy. Minocycline has been suggested as one of the most effective drugs against periodontal pathogens. The aim of this work was to evaluate the minimal inhibitory concentration (MIC) of minocycline on superinfecting microorganisms isolated from the periodontal pocket and the oral cavity of individuals with chronic periodontitis. Isolates of Enterobacteriaceae (n = 25), Staphylococcus spp. (n = 25), Pseudomonas aeruginosa (n = 9) and Candida spp. (n = 25) were included in the study. Minimal inhibitory concentrations (MIC) of minocycline were determined using the Müeller-Hinton agar dilution method. Staphylococcus spp. isolates were the most sensitive to minocycline with a MIC of 8 µg/mL, followed by Enterobacteriaceae with a MIC of 16 µg/mL. The concentration of 16 µg/mL inhibited 96% of Candida spp. isolates. The MIC for 88.8% of the isolates of Pseudomonas aeruginosa was 128 µg/mL. A concentration of 1,000 µg/mL was not enough to inhibit 100% of the tested isolates.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1590/s1806-83242006000300004

Cites

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 29

  1. Ciancio SG, 1982, The effect of short-term administration of minocycline HCl on gingival inflammation and subgingival microflora, J Periodontol, 53, 557, 10.1902/jop.1982.53.9.557 · DOI
  2. Fluit AC, 2001, Frequency of isolation and antimicrobial resistance of Gram-negative and Gram-positive bacteria from patients in intensive care units of 25 European university hospitals participating in the European arm of the SENTRY antimicrobial surveillance program 1997-1998, Eur J Clin Microbiol Infect Dis, 20, 617, 10.1007/s100960100564 · DOI
  3. Gales AC, 2000, Antimicrobial activity and spectrum of the new glycylcycline, GAR-936 test against 1,203 recent clinical bacterial isolates, Diagn Microbiol Infect Dis, 36, 19, 10.1016/S0732-8893(99)00092-9 · DOI · Paper page
  4. Haffajee AD, 2000, Microbial etiological agents of destructive periodontal diseases, Periodontol, 5, 78, 10.1111/j.1600-0757.1994.tb00020.x · DOI · Paper page
  5. Ichimiya T, 1994, In-vitro effects of antimicrobial agents on Pseudomonas aeruginosa biofilm formation, J Antimicrob Chemoter, 34, 331, 10.1093/jac/34.3.331 · doi:10.1093/jac/34.3.331
  6. Ikeda T, 1999, Efficacy of antibacterial drugs in mice with complex infection by Candida albicans and Escherichia coli, J Antibiotics, 52, 552, 10.7164/antibiotics.52.552 · DOI
  7. Kinane DF., 1999, Periodontitis modified by systemic factors, Ann Periodontol, 4, 54, 10.1902/annals.1999.4.1.54 · DOI
  8. Lew MA, 1977, Antifungal activity of four tetracycline analogues against Candida albicans in vitro: Potentiation by amphotericin B., J Infect Dis, 136, 263, 10.1093/infdis/136.2.263 · DOI · Paper page
  9. Loberto JCS, 2004, Staphylococcus spp. in the oral cavity and periodontal pockets of chronic periodontitis patients, Braz J Microbiol, 35, 64
  10. Loe H, 1965, Experimental gingivitis in man, J Periodontol, 36, 177, 10.1902/jop.1965.36.3.177 · DOI · Paper page
  11. Loomer PM., 2000, Microbiological diagnostic testing in the treatment of periodontal diseases, Periodontology, 34, 49, 10.1046/j.0906-6713.2002.003424.x · DOI
  12. Martins CAP, 2002, Presença de Candida spp. em pacientes com periodontite crônica, Cienc Odontol Bras, 5, 75
  13. Mimica LMJ, 1994, Alerta: Pseudomonas aeruginosa resistente a todos os antimicrobianos testados, Rev Contr de Infect Hosp, 1, 12
  14. Nunn ME., 2000, Understanding the etiology of periodontitis: an overview of periodontal risk factors, Periodontology, 32, 11, 10.1046/j.0906-6713.2002.03202.x · DOI · Paper page
  15. Oliveira EE, 1998, Toxinas killer e produção de enzimas por Candida albicans isoladas da mucosa bucal de pacientes com câncer, Rev Soc Bras Med Trop Brasília, 31, 523, 10.1590/S0037-86821998000600003 · doi:10.1590/s0037-86821998000600003
  16. Oplustil CP, 2000, Testes de avaliação da resistência aos antimicrobianos, 165
  17. Pannuti CM, 2001, Prevalência de microrganismos superinfectantes na placa supragengival de deficientes mentais institucionalizados, Rev Pós Grad, 8, 35
  18. Raad I, 1995, Antibiotics and prevention of microbial colonization of catheters, Antimicrob Agents Chemother, 39, 2397, 10.1128/AAC.39.11.2397 · DOI · Paper page
  19. Rams TE, 1991, Candida biotypes in human adult periodontitis, J Oral Microbiol Immunol, 6
  20. Santos SSF, 2002, Prevalência e sensibilidade in vitro de Enterobacteriaceae e Pseudomonas isoladas da cavidade bucal e bolsa periodontal de pacientes com periodontite crônica, Rev Fac Odontol São José dos Campos, 5, 74
  21. Satomi A., 1987, Minocycline Hcl concentration in periodontal pocket after administration of LS-007, J Jap Assoc Periodontol, 29, 937, 10.2329/perio.29.937 · DOI · Paper page
  22. Schierholz JM, 1999, In vitro activity of rifampin-minocyclin coating to Candida albicans, Crit Care Med, 27, 1691, 10.1097/00003246-199908000-00072 · DOI
  23. Slots J, 1990, Age and sex relationship of superinfecting microorganisms in periodontitis patients, Oral Microbiol Immunol, 5, 305, 10.1111/j.1399-302X.1990.tb00430.x · DOI
  24. Socransky SS, 1992, The bacterial etiology of destructive periodontal disease: current concepts, J Periodontol, 63, 322, 10.1902/jop.1992.63.4s.322 · DOI · Paper page
  25. Trzcinski K, 2000, Expression of resistance to tetracyclines in strains of methicillin-resistant Staphylococcus aureus, J Antimicrob Chemother, 45, 763, 10.1093/jac/45.6.763 · DOI · Paper page
  26. van Winkelhoff AJ, 2000, Systemic antibiotic therapy in periodontics, Periodontol, 10, 45, 10.1111/j.1600-0757.1996.tb00068.x · DOI · Paper page
  27. Waterworth PM., 1974, The effect of minocycline on Candida albicans, J Clin Path, 27, 269, 10.1136/jcp.27.4.269 · DOI
  28. Williams RC, 2001, Treatment of periodontitis by local administration of minocycline microspheres: a controlled trial, J Periodontol, 72, 1535, 10.1902/jop.2001.72.11.1535 · DOI · Paper page
  29. Wilson M, 1991, Isolation and identification of bacteria from subgingival plaque, with low susceptibility to minocycline, J Periodontol, 28, 71

Cited by

See all 19

Metadata

Authors
Oliveira, L. F. D., Jorge, A. O. C., & Santos, S. S. F. D.
Affiliations
University of Taubaté
Venue
Brazilian Oral Research
Publisher
FapUNIFESP (SciELO)
Published
2006-09
Volume
20
Issue
3
Pages
202-206
ISSN
1806-8324
DOI
10.1590/s1806-83242006000300004
Cited by
19
References
0

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: In vitro minocycline activity on superinfecting microorganisms isolated from chronic periodontitis patients. https://app.cochat.ai/papers/10.1590/s1806-83242006000300004
The paper
Oliveira, L. F. D., Jorge, A. O. C., & Santos, S. S. F. D. (2006). In vitro minocycline activity on superinfecting microorganisms isolated from chronic periodontitis patients. Brazilian Oral Research. https://doi.org/10.1590/s1806-83242006000300004

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.