Duloxetine: A Dual Serotonin‐Norepinephrine Reuptake Inhibitor for Treatment of Major Depressive Disorder

Kirwin, Jennifer L.; Gören, Jessica L.

doi:10.1592/phco.25.3.396.61600

Cited by 43Treatment of Major DepressionPsychological Treatments and DisordersAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Duloxetine: A Dual Serotonin‐Norepinephrine Reuptake Inhibitor for Treatment of Major Depressive Disorder

Kirwin, Jennifer L., Gören, Jessica L.·2005·Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy

DOI 10.1592/phco.25.3.396.61600

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Abstract

The burden of mental illness has been underestimated worldwide. Depression was the fourth leading cause of disease burden in the world in 1990 and is projected to be the second leading cause of disability by 2020. It is a leading cause of morbidity and mortality in the United States, costing billions of dollars annually in direct and indirect medical costs and losses in productivity. Patients with major depressive disorder (MDD) may experience both psychological and medical complaints, including somatic sensations or pain. Some antidepressants have been shown to treat chronic pain syndromes, but despite the variety of antidepressants available in the United States, only 65–70% of patients respond to initial antidepressant treatment. Treatments are limited by delayed onset of antidepressant effects, side effects, partial response, and treatment resistance. Duloxetine, approved by the U.S. Food and Drug Administration for the treatment of MDD, is a reuptake inhibitor at serotonergic and noradrenergic neurons and appears to have low affinity for other neurotransmitter systems. In clinical trials, duloxetine was effective for the treatment of MDD and was well tolerated. Further study is needed to compare its efficacy with that of other antidepressants, to clarify effects on somatic symptoms, and to assess potential adverse cardiovascular and sexual side effects. Duloxetine is also approved for the management of diabetic peripheral neuropathic pain and is under investigation for the treatment of stress urinary incontinence in women.

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Side effects more specific to serotonin or norepinephrine have become a concern.
“In addition, side effects which are more specific to serotonin or norepinephrine also have become a concern.56”
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Authors: Kirwin, J. L., & Gören, J. L.
Affiliations: Northeastern University (US)
McLean Hospital (US)
ORCID: Kirwin, Jennifer L.
Gören, Jessica L.
Venue: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
Publisher: Wiley
Published: 2005-03
Volume: 25
Issue: 3
Pages: 396-410
ISSN: 0277-0008 (ISSN-L)
1875-9114
DOI: 10.1592/phco.25.3.396.61600
OpenAlex: W2080466203
Cited by: 42
References: 56
Citations by year: 2026: 1 · 2025: 4 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 1 · 2018: 3 · 2017: 1 · 2015: 1 · 2014: 2 · 2012: 1
FWCI: 2.55
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2512 d)
Locations: Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Social Sciences › Psychology › Clinical Psychology › Psychological Treatments and Disorders
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords: duloxetine, major depressive disorder, serotonin-norepinephrine reuptake inhibitors, antidepressants, treatment-resistant depression, antidepressant efficacy, antidepressant side effects, diabetic peripheral neuropathic pain, stress urinary incontinence, somatic symptoms of depression, cardiovascular side effects, sexual side effects
MeSH terms: Duloxetine Hydrochloride, Adolescent, Adult, Aged, Depressive Disorder, Major, Major Depressive Disorder, Drug Interactions, Humans, Middle Aged, Thiophenes, Randomized Controlled Trials as Topic, Selective Serotonin Reuptake Inhibitors

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Duloxetine: A Dual Serotonin‐Norepinephrine Reuptake Inhibitor for Treatment of Major Depressive Disorder

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