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Cited by 199

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Brain Tumor Tropism of Transplanted Human Neural Stem Cells Is Induced by Vascular Endothelial Growth Factor

Open access
Schmidt, Nils Ole, Przylecki, Wojciech, Yang, Wendy, Ziu, Mateo, Teng, Yang D., Kim, Seung U., Black, Peter Mcl., Aboody, Karen S., Carroll, Rona S.·2005·Neoplasia
DOI 10.1593/neo.04781
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Abstract

The transplantation of neural stem cells (NSCs) offers a new potential therapeutic approach as a cell-based delivery system for gene therapy in brain tumors. This is based on the unique capacity of NSCs to migrate throughout the brain and to target invading tumor cells. However, the signals controlling the targeted migration of transplanted NSCs are poorly defined. We analyzed the in vitro and in vivo effects of angiogenic growth factors and protein extracts from surgical specimens of brain tumor patients on NSC migration. Here, we demonstrate that vascular endothelial growth factor (VEGF) is able to induce a long-range attraction of transplanted human NSCs from distant sites in the adult brain. Our results indicate that tumor-upregulated VEGF and angiogenic-activated microvasculature are relevant guidance signals for NSC tropism toward brain tumors.

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Show all 4 references

Research works printed but not linked: 15

  1. Aboody, 2000, From the cover: neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas, Proc Natl Acad Sci USA, 97, 12846, 10.1073/pnas.97.23.12846 · DOI · Paper page
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Cited by

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Metadata

Authors
Schmidt, N. O., Przylecki, W., Yang, W., Ziu, M., Teng, Y. D., Kim, S. U., Black, P. M., Aboody, K. S., & Carroll, R. S.
Venue
Neoplasia
Publisher
Elsevier BV
Published
2005-06
Volume
7
Issue
6
Pages
623-630
ISSN
1476-5586 (ISSN-L)
DOI
10.1593/neo.04781
OpenAlex
W2041745928
Cited by
199
References
4
FWCI
4.96
Type
journal article
Language
en
Open access
gold
Licence
Funders
Deutsche Forschungsgemeinschaft

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CoChat. (2026). Citation check: Brain Tumor Tropism of Transplanted Human Neural Stem Cells Is Induced by Vascular Endothelial Growth Factor. https://app.cochat.ai/papers/10.1593/neo.04781
The paper
Schmidt, N. O., Przylecki, W., Yang, W., Ziu, M., Teng, Y. D., Kim, S. U., Black, P. M., Aboody, K. S., & Carroll, R. S. (2005). Brain Tumor Tropism of Transplanted Human Neural Stem Cells Is Induced by Vascular Endothelial Growth Factor. Neoplasia. https://doi.org/10.1593/neo.04781

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.