The DOI matches its Crossref record; 116 of the 116 references it cites were found in a registry or an index.
Stem Cells: A Revolution in Therapeutics—Recent Advances in Stem Cell Biology and Their Therapeutic Applications in Regenerative Medicine and Cancer Therapies
Abstract
Basic and clinical research accomplished during the last few years on embryonic, fetal, amniotic, umbilical cord blood, and adult stem cells has constituted a revolution in regenerative medicine and cancer therapies by providing the possibility of generating multiple therapeutically useful cell types. These new cells could be used for treating numerous genetic and degenerative disorders. Among them, age-related functional defects, hematopoietic and immune system disorders, heart failures, chronic liver injuries, diabetes, Parkinson's and Alzheimer's diseases, arthritis, and muscular, skin, lung, eye, and digestive disorders as well as aggressive and recurrent cancers could be successfully treated by stem cell-based therapies. This review focuses on the recent advancements in adult stem cell biology in normal and pathological conditions. We describe how these results have improved our understanding on critical and unique functions of these rare sub-populations of multipotent and undifferentiated cells with an unlimited self-renewal capacity and high plasticity. Finally, we discuss some major advances to translate the experimental models on ex vivo and in vivo expanded and/or differentiated stem cells into clinical applications for the development of novel cellular therapies aimed at repairing genetically altered or damaged tissues/organs in humans. A particular emphasis is made on the therapeutic potential of different tissue-resident adult stem cell types and their in vivo modulation for treating and curing specific pathological disorders.
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Cites
Adult Cardiac Stem Cells Are Multipotent and Support Myocardial Regeneration
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Mesenchymal stem cells reside in virtually all post-natal organs and tissues
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Adipose-derived stem cells for regenerative medicine
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Socializing with the Neighbors
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G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4
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Cited by
Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells
Boitano, A. E., Wang, J., Romeo, R., Bouchez, L. C., Parker, A. E., Sutton, S. E., Walker, J. R., Flaveny, C. A., Perdew, G. H., Denison, M. S., et al. (2010) · Science · doi:10.1126/science.1191536 · Cited by 1,047
Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation
Orford, K. W., & Scadden, D. T. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2269 · Cited by 851
Carosella, E. D., Rouas-Freiss, N., Roux, D. T.-L., Moreau, P., & LeMaoult, J. (2015) · Advances in Immunology · doi:10.1016/bs.ai.2015.04.001 · Cited by 395
Stem Cell Clinics Online: The Direct-to-Consumer Portrayal of Stem Cell Medicine
Lau, D., Ogbogu, U., Taylor, B., Stafinski, T., Menon, D., & Caulfield, T. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.11.001 · Cited by 337
Pablico-Lansigan, M. H., Situ, S. F., & Samia, A. C. S. (2013) · Nanoscale · doi:10.1039/c3nr00544e · Cited by 172
Metadata
- Authors
- Mimeault, M., Hauke, R., & Batra, S. K.
- Venue
- Clinical Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2007-08-01
- Volume
- 82
- Issue
- 3
- Pages
- 252-264
- ISSN
- 0009-9236 (ISSN-L)
- 1532-6535
- OpenAlex
- W1988358491
- Cited by
- 450
- References
- 116
- FWCI
- 15.23
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Stem Cells: A Revolution in Therapeutics—Recent Advances in Stem Cell Biology and Their Therapeutic Applications in Regenerative Medicine and Cancer Therapies. https://app.cochat.ai/papers/10.1038/sj.clpt.6100301
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- Mimeault, M., Hauke, R., & Batra, S. K. (2007). Stem Cells: A Revolution in Therapeutics—Recent Advances in Stem Cell Biology and Their Therapeutic Applications in Regenerative Medicine and Cancer Therapies. Clinical Pharmacology & Therapeutics. https://doi.org/10.1038/sj.clpt.6100301
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
