Cited by 97Radiomics and Machine Learning in Medical ImagingGlioma Diagnosis and TreatmentBrain Tumor Detection and Classification

Radiologically Defined Ecological Dynamics and Clinical Outcomes in Glioblastoma Multiforme: Preliminary Results

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Zhou, Mu, Hall, Lawrence, Goldgof, Dmitry, Russo, Robin, Balagurunathan, Yoganand, Gillies, Robert, Gatenby, Robert·2014·Translational Oncology

Abstract

MATERIALS AND METHODS: We examined pretreatment magnetic resonance imaging (MRI) examinations from 32 patients with glioblastoma multiforme (GBM) enrolled in The Cancer Genome Atlas (TCGA). Spatial variations in T1 post-gadolinium and either T2-weighted or fluid attenuated inversion recovery sequences from each tumor MRI study were used to characterize each small region of the tumor by its local contrast enhancement and edema/cellularity ("habitat"). The patient cohort was divided into group 1 (survival < 400 days, n = 16) and group 2 (survival > 400 days, n = 16). RESULTS: Histograms of relative values in each sequence demonstrated that the tumor regions were consistently divided into high and low blood contrast enhancement, each of which could be subdivided into regions of high, low, and intermediate cell density/interstitial edema. Group 1 tumors contained greater volumes of habitats with low contrast enhancement but intermediate and high cell density (not fully necrotic) than group 2. Both leave-one-out and 10-fold cross-validation schemes demonstrated that individual patients could be correctly assigned to the short or long survival group with 81.25% accuracy. CONCLUSION: We demonstrate that novel image analytic techniques can characterize regional habitat variations in GBMs using combinations of MRI sequences. A preliminary study of 32 patients from the TCGA database found that the distribution of MRI-defined habitats varied significantly among the different survival groups. Radiologically defined ecological tumor analysis may provide valuable prognostic and predictive biomarkers in GBM and other tumors.

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  • The distribution of habitats in patients with glioblastoma multiforme can enable discrimination between cancers that progress quickly (<400 days of survival) and those that are more indolent.

    “The distribution of these habitats in patients with glioblastoma multiforme, for example, can enable us to discriminate between cancers that progress quickly (<400 days of survival) and those that are more indolent (37).”

    From Radiomics: Images Are More than Pictures, They Are Data (2016) · cites this paper as [37]

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Authors
Zhou, M., Hall, L., Goldgof, D., Russo, R., Balagurunathan, Y., Gillies, R., & Gatenby, R.
Affiliations
  • University of South Florida (US)
  • Moffitt Cancer Center (US)
Corresponding author
Gatenby, Robert
Venue
Translational Oncology
Publisher
Elsevier BV
Published
2014-02
Volume
7
Issue
1
Pages
5-13
ISSN
1936-5233 (ISSN-L)
OpenAlex
W2081296990
Cited by
97
References
42
Citations by year
2026: 4 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 5 · 2021: 9 · 2020: 12 · 2019: 7 · 2018: 13 · 2017: 9 · 2016: 12 · 2015: 13 · 2014: 1
FWCI
9.13
Type
journal article
Language
en
Open access
Locations
  • Translational Oncology (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Cancer Institute (U54CA143970, U01CA143062, R01CA170595, R01CA077575)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiomics and Machine Learning in Medical Imaging
  • Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
  • Life Sciences › Neuroscience › Neurology › Brain Tumor Detection and Classification
Keywords
glioblastoma, tumor microenvironment, contrast-enhanced T1-weighted imaging, FLAIR, tumor cell density, interstitial edema, tumor necrosis, survival prediction, prognostic factors

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