The DOI matches its Crossref record; 210 of the 210 references it cites were found in a registry or an index.
Animal models of head trauma
Open accessAbstract
Animal models of traumatic brain injury (TBI) are used to elucidate primary and secondary sequelae underlying human head injury in an effort to identify potential neuroprotective therapies for developing and adult brains. The choice of experimental model depends upon both the research goal and underlying objectives. The intrinsic ability to study injury-induced changes in behavior, physiology, metabolism, the blood/tissue interface, the blood brain barrier, and/or inflammatory- and immune-mediated responses, makes in vivo TBI models essential for neurotrauma research. Whereas human TBI is a highly complex multifactorial disorder, animal trauma models tend to replicate only single factors involved in the pathobiology of head injury using genetically well-defined inbred animals of a single sex. Although such an experimental approach is helpful to delineate key injury mechanisms, the simplicity and hence inability of animal models to reflect the complexity of clinical head injury may underlie the discrepancy between preclinical and clinical trials of neuroprotective therapeutics. Thus, a search continues for new animal models, which would more closely mimic the highly heterogeneous nature of human TBI, and address key factors in treatment optimization.
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“They are critical in understanding the links between the clinical outcomes of TBI and some cellular/ molecular dysfunction resulting in neuroendocrine dysfunction (193).”
From Pituitary Dysfunction After Traumatic Brain Injury: A Clinical and Pathophysiological Approach (2015) · cites this paper as [193]
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Items 201–210 of 210
Development of Regional Cerebral Oedema After Lateral Fluid-Percussion Brain Injury in the Rat
McIntosh, T. K., Soares, H. D., Thomas, M., et al. (1990) · Springer eBooks · doi:10.1007/978-3-7091-9115-6_89 · Cited by 18
Changes in ICBF, morphology and related parameters by fluid percussion injury
Qian, L., Ohno, K., Maehara, T., Tominaga, B., Hirakawa, K., Kuroiwa, T., Takakuda, K., & Miyairi, H. (1996) · Acta Neurochirurgica · doi:10.1007/bf01411731 · Cited by 16
Validation of a Closed Head Injury Model for use in Long-Term Studies
Mulder, G. D., van Rossem, K., Reempts, J. V., et al. (2000) · Springer eBooks · doi:10.1007/978-3-7091-6346-7_85 · Cited by 15
Intracranial Pressure in a Modified Experimental Model of Closed Head Injury
Engelborghs, K., Verlooy, J., Deuren, B. V., Reempts, J. V., & Borgers, M. J. (1997) · Springer eBooks · doi:10.1007/978-3-7091-6837-0_38 · Cited by 15
Pharmacologic treatment of acute traumatic brain injury
Faden, A. I. (1996) · JAMA · doi:10.1001/jama.276.7.569 · Cited by 15
Redistribution of Facial Nerve Motor Neurons after Recovery from Nerve Crushing Injury in the Gerbil
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Failure of Cerebral Autoregulation in an Experimental Diffuse Brain Injury Model
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Effect of experimental blunt head injury on acute regional cerebral blood flow and edema.
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Brain edema after an experimental missile wound.
Carey, M. E., Sarna, G. S., & Farrell, J. B. (1990) · PubMed · Cited by 4
Flagged first, then by citations
Research works printed but not linked: 2
- Lighthall JW, Anderson TE. In: The neurobiology of cenral nervous system trauma (Salzman SK, Faden AI, eds), pp 3–12. New York/Oxford: Oxford University Press, 1994.
- Di X, Zhang T, Mullins P, Faden AI. Novel, potent, and selective group II mGluR agonist LY379268 ameliorates cognitive and motor deficits induced by control cortical impact injury in mouse. J Neurotrauma 17: 960, 2000.
Cited by
Sorted by citations
Blood–brain barrier breakdown as a therapeutic target in traumatic brain injury
Shlosberg, D., Benifla, M., Kaufer, D., & Friedman, A. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.74 · Cited by 897
Comparison of Treatment Effects between Animal Experiments and Clinical Trials: Systematic Review
Perel, P., Roberts, I., Sena, E., Wheble, P., Briscoe, C., Sandercock, P., Macleod, M., Mignini, L. E., Jayaram, P., & Khan, K. S. (2007) · BMJ · doi:10.1136/bmj.39048.407928.be · Cited by 827
Prakash, R., & Carmichael, S. T. (2015) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000248 · Cited by 296
In Situ Detection of Inflammatory Mediators in Post Mortem Human Brain Tissue after Traumatic Injury
Frugier, T., Morganti-Kossmann, M. C., O'Reilly, D., & McLean, C. A. (2010) · Journal of Neurotrauma · doi:10.1089/neu.2009.1120 · Cited by 278
Pituitary Dysfunction After Traumatic Brain Injury: A Clinical and Pathophysiological Approach
Tanriverdi, F., Schneider, H. J., Aimaretti, G., Masel, B. E., Casanueva, F. F., & Kelestimur, F. (2015) · Endocrine Reviews · doi:10.1210/er.2014-1065 · Cited by 218
Metadata
- Authors
- Cernak, I.
- Venue
- NeuroRX
- Published
- 2005-07
- Volume
- 2
- Issue
- 3
- Pages
- 410-422
- ISSN
- 1545-5343 (ISSN-L)
- PMC
- PMC1144485
- OpenAlex
- W2056804957
- Semantic Scholar
- 05857a6126f1be753c6b0c93d060bf3ee85f30ce
- Cited by
- 462
- References
- 210
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 21 · 2023: 15 · 2022: 15 · 2021: 21 · 2020: 16 · 2019: 30 · 2018: 26 · 2017: 31 · 2016: 41 · 2015: 36 · 2014: 37 · 2013: 29 · 2012: 31
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- NeuroRx (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- WBI Studies Repository (submittedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
- Physical Sciences › Engineering › Biomedical Engineering › Automotive and Human Injury Biomechanics
- Keywords
- traumatic brain injury, animal models, neuroprotection, secondary injury mechanisms, blood-brain barrier, neuroinflammation, preclinical to clinical translation
- MeSH terms
- Animals, Brain, Brain Injuries, Disease Models, Animal, Craniocerebral Trauma, Humans, Head Injuries, Closed, Head Injuries, Penetrating
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