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The challenge of integrating devices into the central nervous system.
Abstract
Implanted biomedical devices are playing an increasingly important role in the treatment of central nervous system disorders. While devices such as deep brain stimulation electrodes and drug delivery systems have shown clinical success in chronic applications, other devices such as nerve guidance substrates and recording electrodes that operate over a very short length scale have not had the same kind of clinical impact. By reviewing what is currently known about the brain tissue response to implanted electrodes, the authors propose that the foreign-body response, which changes the tissue structure immediately surrounding implanted devices, may be the reason near-function devices are stalled in preclinical development. The article concludes by reviewing recent efforts to reduce the foreign body response, which shows promise to accelerate the clinical development of this new generation of biomedical devices.
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Systems have performed well during acute recordings, but failed to function reliably over clinically relevant timelines, the result of brain tissue reaction against implants.
“Systems have performed well during acute recordings, but failed to function reliably over clinically relevant timelines, the result of brain tissue reaction against implants, making biocompatibility of implanted BCI systems a primary concern in current device design (Polikov et al., 2005; Winslow and Tresco, 2010; Tresco and Winslow, 2011).”
From Human Brain/Cloud Interface (2019) · cites this paper as Tresco and Winslow, 2011
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Metadata
- Authors
- Tresco, P. A., & Winslow, B. D.
- Affiliations
- University of Utah (US)
- ORCID
- Winslow, Brent D.
- Venue
- Critical Reviews™ in Biomedical Engineering
- Publisher
- Begell House
- Published
- 2011
- Volume
- 39
- Issue
- 1
- Pages
- 29-44
- ISSN
- 0278-940X (ISSN-L)
- OpenAlex
- W1976803735
- Cited by
- 65
- References
- 0
- Citations by year
- 2025: 4 · 2024: 2 · 2023: 4 · 2022: 5 · 2021: 4 · 2020: 1 · 2019: 5 · 2018: 8 · 2017: 6 · 2016: 2 · 2015: 5 · 2014: 9 · 2013: 4 · 2012: 3
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Critical Reviews in Biomedical Engineering (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Keywords
- foreign body reaction, implanted electrodes, central nervous system, recording electrodes, deep brain stimulation, drug delivery systems, preclinical drug development, chronic implantation
- MeSH terms
- Central Nervous System, Electrodes, Foreign-Body Reaction, Humans, Neural Prostheses
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