The Microbiome of Oral Cancer
Abstract
The pathogenesis of oral cancer is complex, and not all relevant factors involved in it have been determined. In particular, the role of the microbiota is not well understood because of difficulties in isolating and culturing its organisms. However, the recent development of metagenomic sequencing allows the discovery of all the DNA sequences in a specimen, and thus, the microbiome is now under intensive investigation. Studies of the bacteriome, the mycobiome, and the virome have revealed new organisms and have uncovered various differences between healthy persons and patients with oral cancer. In addition, sequencing of human samples shows the existence of DNA sequences that may be from novel microbes but are actually of unknown origin and so are referred to as the dark matter. The large volumes of data that are being produced by sequencing projects must be studied further to reveal novel pathogens and new pathways in the development of oral cancer.
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Various disease states are associated with the oral microbiome, including caries, periodontal disease, oral, esophageal, pancreatic, and colorectal cancers, cardiovascular disease, and inflammatory bowel disease.
“This is demonstrated by the association of various disease states with the oral microbiome, including not only caries and periodontal disease but also oral, esophageal, pancreatic, and colorectal cancers, cardiovascular disease, and inflammatory bowel disease.147, 148, 149, 150, 151, 152, 153”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [149]
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“Most of the metagenomic and metatranscriptomics studies are focused on cancers from the gastrointestinal tract [35], or skin [36], or head/neck regions [37].”
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Current Insights on Neoplasms and Adequate Dental Care for Patients with Oral Cancer
de Matos, J. D. M., Nakano, L. J. N., Lopes, G. D. R. S., et al. (2023) · International journal of odontostomatology · doi:10.4067/s0718-381x2023000300356
- Authors
- Shillitoe, E. J.
- Affiliations
- SUNY Upstate Medical University (US)
- Corresponding author
- Shillitoe, Edward J.
- Venue
- Critical Reviews™ in Oncogenesis
- Publisher
- Begell House
- Published
- 2018
- Volume
- 23
- Issue
- 3-4
- Pages
- 153-160
- ISSN
- 0893-9675 (ISSN-L)
- OpenAlex
- W2892130198
- Cited by
- 17
- References
- 0
- Citations by year
- 2023: 5 · 2022: 4 · 2021: 4 · 2020: 3 · 2019: 1
- FWCI
- 2.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Critical Reviews™ in Oncogenesis (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
- Keywords
- oral cancer, oral microbiota, bacteriome, fungal communities, virome, metagenomics, dark matter, novel microbial taxa, carcinogenesis
- MeSH terms
- Animals, Bacterial Infections, Cell Transformation, Neoplastic, Disease Susceptibility, Humans, Mouth Neoplasms, Mycoses, Virus Diseases, Metagenome, Metagenomics, Microbiota
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