Hypoxia and Serum Deprivation-Induced Apoptosis in Mesenchymal Stem Cells

Zhu, Weiquan; Chen, Jinghai; Cong, Xiangfeng; Hu, Shengshou; Chen, Xi

doi:10.1634/stemcells.2005-0121

Cited by 399Cell death mechanisms and regulationMesenchymal stem cell researchCardiac Ischemia and Reperfusion

Hypoxia and Serum Deprivation-Induced Apoptosis in Mesenchymal Stem Cells

Zhu, Weiquan, Chen, Jinghai, Cong, Xiangfeng, Hu, Shengshou, Chen, Xi·2006·Stem Cells

DOI 10.1634/stemcells.2005-0121

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Abstract

In recent years, the understanding that regeneration progresses at the level of the myocardium has placed stem cell research at the center stage in cardiology. Despite an increasing interest in cell transplant research, relatively little is known about the biochemical regulation of the stem cell itself after transplantation into an ischemic heart. We demonstrated here, using rat mesenchymal stem cells (MSCs), that cells undergo caspase-dependent apoptosis in response to hypoxia and serum deprivation (SD), which are both components of ischemia in vivo. In particular, the treated cells exhibited mitochondrial dysfunction, including cytochrome C release, loss in ΔΨm, and Bax accumulation, but in a p53-independent manner. Although the cells treated by hypoxia/SD possess the activity of caspase-8, zIEDT-fmk, a specific caspase-8 inhibitor, failed to inhibit cell apoptosis induced in our system. Taken together, our findings indicate that MSCs are sensitive to hypoxia/SD stimuli that involve changes in mitochondrial integrity and function but are potentially independent of caspase-8.

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Crossref · 10.1634/stemcells.2005-0121

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Some studies reported conflicting results showing negative or no effects on MSCs by hypoxia.
“Yet, some studies reported conflicting results showing negative or no effects on MSCs by hypoxia [34–36].”
From Short-term physiological hypoxia potentiates the therapeutic function of mesenchymal stem cells (2018) · cites this paper as [36]

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Authors: Zhu, W., Chen, J., Cong, X., Hu, S., & Chen, X.
Affiliations: Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Corresponding author: Hu, Shengshou
Chen, Xi
ORCID: Zhu, Weiquan
Chen, Jinghai
Hu, Shengshou
Chen, Xi
Venue: Stem Cells
Publisher: Oxford University Press (OUP)
Published: 2005-10-27
Volume: 24
Issue: 2
Pages: 416-425
ISSN: 1066-5099 (ISSN-L)
1549-4918
DOI: 10.1634/stemcells.2005-0121
OpenAlex: W2083123206
Cited by: 399
References: 47
Citations by year: 2025: 9 · 2024: 7 · 2023: 10 · 2022: 21 · 2021: 9 · 2020: 18 · 2019: 11 · 2018: 31 · 2017: 28 · 2016: 22 · 2015: 31 · 2014: 33 · 2013: 38 · 2012: 35
FWCI: 3.64
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: Stem Cells (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China
National Science Fund for Distinguished Young Scholars
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
Keywords: mesenchymal stem cells, hypoxia, serum deprivation, apoptosis, caspase-8, mitochondrial dysfunction, cytochrome c release, Bax, p53-independent apoptosis, myocardial ischemia, stem cell transplantation, cardiac regeneration
MeSH terms: Animals, Mitochondria, Translocation, Genetic, Cell Hypoxia, Culture Media, Serum-Free, Apoptosis, Caspases, bcl-2-Associated X Protein, Rats, Caspase 3, Caspase 8, Mesenchymal Stem Cells

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Hypoxia and Serum Deprivation-Induced Apoptosis in Mesenchymal Stem Cells

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