Identification of MicroRNAs Involved in Hypoxia- and Serum Deprivation-Induced Apoptosis in Mesenchymal Stem Cells
Open accessAbstract
The use of bone marrow mesenchymal stem cell- (MSC) transplantation therapy for cardiac diseases is limited due to poor survival of implanted cells. MicroRNAs (miRNAs) have been reported to be involved in regulating almost all cellular processes, including apoptosis. In this study, we found that the miRNA profile was altered during apoptosis induced by hypoxia and serum deprivation (hypoxia/SD). We further revealed that over-expression of miR-21, miR-23a and miR-210 could promote the survival of MSCs exposed to hypoxia/SD. In contrast, down-regulation of miR-21, miR-23a and miR-503 aggravated apoptosis of MSCs. It was indicated that these miRNAs may play important roles during MSC apoptosis induced by hypoxia/SD.
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Overexpression of miR-23a can improve hypoxia/serum deprivation-induced MSC apoptosis and increase their survival rate; downregulation of miR-23 can exacerbate TNF-α-induced MSC apoptosis by regulating caspase-7.
“Overexpression of miR-23a can improve hypoxia/serum deprivation-induced MSC apoptosis and increase their survival rate; conversely, downregulation of miR-23 can exacerbate TNF-α-induced MSC apoptosis by regulating caspase-7 [55,56].”
From Recent advances of miR-23 in human diseases and growth development (2025) · cites this paper as [55]
The Results and Discussion section reports that overexpressing miR-23a promoted MSC survival under hypoxia and serum deprivation. It also reports that miR-23a knockdown increased apoptosis under those conditions, but does not establish the sentence’s separate claim about TNF-α-induced apoptosis or regulation of caspase-7. (LLM, conf=0.87)
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- Authors
- Nie, Y., Han, B.-M., Liu, X.-B., Yang, J.-J., Wang, F., Cong, X.-F., & Chen, X.
- Affiliations
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Corresponding author
- Chen, Xi
- Venue
- International Journal of Biological Sciences
- Publisher
- Ivyspring International Publisher
- Published
- 2011
- Volume
- 7
- Issue
- 6
- Pages
- 762-768
- ISSN
- 1449-2288 (ISSN-L)
- PMC
- PMC3119848
- OpenAlex
- W2109734397
- Cited by
- 104
- References
- 30
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 8 · 2020: 5 · 2019: 2 · 2018: 4 · 2017: 1 · 2016: 14 · 2015: 14 · 2014: 12 · 2013: 16 · 2012: 16
- FWCI
- 5.12
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- International Journal of Biological Sciences (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (30770862, 30871024)
- National Key Research and Development Program of China (2005CB724600, Program 973)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- microRNA, mesenchymal stem cells, apoptosis, hypoxia, serum deprivation, miR-21, miR-23a, miR-210, miR-503, stem cell survival, cardiac regeneration, bone marrow transplantation
- MeSH terms
- Animals, Hypoxia, Down-Regulation, Up-Regulation, Rats, Sprague-Dawley, Apoptosis, Gene Expression Profiling, MicroRNAs, Rats, Gene Knockdown Techniques, Mesenchymal Stem Cells
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