The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Multipotent Stem Cells from Umbilical Cord: Cord Is Richer than Blood!
Open accessAbstract
The identification of mesenchymal stem cell (MSC) sources that are easily obtainable is of utmost importance. Several studies have shown that MSCs could be isolated from umbilical cord (UC) units. However, the presence of MSCs in umbilical cord blood (UCB) is controversial. A possible explanation for the low efficiency of MSCs from UCB is the use of different culture conditions by independent studies. Here, we compared the efficiency in obtaining MSCs from unrelated paired UCB and UC samples harvested from the same donors. Samples were processed simultaneously, under the same culture conditions. Although MSCs from blood were obtained from only 1 of the 10 samples, we were able to isolate large amounts of multipotent MSCs from all UC samples, which were able to originate different cell lineages. Since the routine procedure in UC banks has been to store the blood and discard other tissues, such as the cord and/or placenta, we believe our results are of immediate clinical value. Furthermore, the possibility of originating different cell lines from the UC of neonates born with genetic defects may provide new cellular research models for understanding human malformations and genetic disorders, as well as the possibility of testing the effects of different therapeutic drugs. Disclosure of potential conflicts of interest is found at the end of this article.
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1 retracted
RETRACTED ARTICLE: Pluripotency of mesenchymal stem cells derived from adult marrow
Jiang, Y., Jahagirdar, B. N., Reinhardt, R. L., Schwartz, R. E., Keene, C. D., Ortiz-Gonzalez, X. R., Reyes, M., Lenvik, T., Lund, T., Blackstad, M., et al. (2002) · Nature · doi:10.1038/nature00870 · Cited by 5,518
RetractedMultilineage Cells from Human Adipose Tissue: Implications for Cell-Based Therapies
Zuk, P. A., Zhu, M., Mizuno, H., Huang, J., Futrell, J. W., Katz, A. J., Benhaim, P., Lorenz, H. P., & Hedrick, M. H. (2001) · Tissue Engineering · doi:10.1089/107632701300062859 · Cited by 7,956
Human Adipose Tissue Is a Source of Multipotent Stem Cells
Zuk, P. A., Zhu, M., Ashjian, P., De Ugarte, D. A., Huang, J. I., Mizuno, H., Alfonso, Z. C., Fraser, J. K., Benhaim, P., & Hedrick, M. H. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-02-0105 · Cited by 6,664
Kern, S., Eichler, H., Stoeve, J., Klüter, H., & Bieback, K. (2006) · STEM CELLS · doi:10.1634/stemcells.2005-0342 · Cited by 3,370
Mesenchymal stem cells reside in virtually all post-natal organs and tissues
Meirelles, L. D. S., Chagastelles, P. C., & Nardi, N. B. (2006) · Journal of Cell Science · doi:10.1242/jcs.02932 · Cited by 2,485
Stem Cell Properties of Human Dental Pulp Stem Cells
Gronthos, S., Brahim, J., Li, W., Fisher, L. W., Cherman, N., Boyde, A., DenBesten, P., Robey, P. G., & Shi, S. (2002) · Journal of Dental Research · doi:10.1177/154405910208100806 · Cited by 2,112
Isolation of amniotic stem cell lines with potential for therapy
De Coppi, P., Bartsch, G., Siddiqui, M. M., Xu, T., Santos, C. C., Perin, L., Mostoslavsky, G., Serre, A. C., Snyder, E. Y., Yoo, J. J., et al. (2007) · Nature Biotechnology · doi:10.1038/nbt1274 · Cited by 1,869
Mesenchymal progenitor cells in human umbilical cord blood
Erices, A., Conget, P., & Minguell, J. J. (2000) · British Journal of Haematology · doi:10.1046/j.1365-2141.2000.01986.x · Cited by 1,613
Mesenchymal Stem Cells in the Wharton's Jelly of the Human Umbilical Cord
Wang, H., Hung, S., Peng, S., Huang, C., Wei, H., Guo, Y., Fu, Y., Lai, M., & Chen, C. (2004) · STEM CELLS · doi:10.1634/stemcells.2004-0013 · Cited by 1,378
Isolation of multipotent mesenchymal stem cells from umbilical cord blood
Lee, O. K., Kuo, T. K., Chen, W.-M., Lee, K.-D., Hsieh, S.-L., & Chen, T.-H. (2004) · Blood · doi:10.1182/blood-2003-05-1670 · Cited by 1,360
Cited by
Tissue Engineering and Cell-Based Therapies for Fractures and Bone Defects
Perez, J. R., Kouroupis, D., Li, D. J., Best, T. M., Kaplan, L., & Correa, D. (2018) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2018.00105 · Cited by 390
Metadata
- Authors
- Secco, M., Zucconi, E., Vieira, N. M., Fogaça, L. L. Q., Cerqueira, A., Carvalho, M. D. F., Jazedje, T., Okamoto, O. K., Muotri, A. R., & Zatz, M.
- Venue
- Stem Cells
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-10-11
- Volume
- 26
- Issue
- 1
- Pages
- 146-150
- ISSN
- 1066-5099 (ISSN-L)
- 1549-4918
- OpenAlex
- W1990758819
- Cited by
- 398
- References
- 32
- FWCI
- 11.71
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Secco, M., Zucconi, E., Vieira, N. M., Fogaça, L. L. Q., Cerqueira, A., Carvalho, M. D. F., Jazedje, T., Okamoto, O. K., Muotri, A. R., & Zatz, M. (2008). Multipotent Stem Cells from Umbilical Cord: Cord Is Richer than Blood! Stem Cells. https://doi.org/10.1634/stemcells.2007-0381
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