The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
LIF/STAT3 Signaling Fails to Maintain Self‐Renewal of Human Embryonic Stem Cells
Open accessAbstract
Murine embryonic stem (mES) cells remain undifferentiated in the presence of leukemia inhibitory factor (LIF), and activation of signal transducer and activator of transcription 3 (STAT3) via LIF receptor (LIFR) signaling appears sufficient for maintenance of mES cell pluripotency. Anecdotal and contradictory accounts exist for the action of LIF in the culture of human embryonic stem cells, and the nature of LIF signaling and whether the LIF-STAT3 pathway is conserved in human embryonic stem cells (hESCs) has not been systematically explored. In this study, we show that the LIFRbeta and the signaling subunit gp130 are expressed in hESCs and that human LIF can induce STAT3 phosphorylation and nuclear translocation in hESCs. Nevertheless, despite the functional activation of the LIF-STAT3 signaling pathway, human LIF is unable to maintain the pluripotent state of hESCs. Feeder-free culture conditions that maintain hESCs in an undifferentiated state do not show activation of STAT3, suggesting that distinct signaling mechanisms govern the self-renewal of hESCs.
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Cited by
Embryonic Stem Cells: Prospects for Developmental Biology and Cell Therapy
Wobus, A. M., & Boheler, K. R. (2005) · Physiological Reviews · doi:10.1152/physrev.00054.2003 · Cited by 782
The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation
Lian, I., Kim, J., Okazawa, H., Zhao, J., Zhao, B., Yu, J., Chinnaiyan, A., Israel, M. A., Goldstein, L. S. B., Abujarour, R., et al. (2010) · Genes & Development · doi:10.1101/gad.1903310 · Cited by 745
Chan, Y.-S., Göke, J., Ng, J.-H., Lu, X., Gonzales, K. A. U., Tan, C.-P., Tng, W.-Q., Hong, Z.-Z., Lim, Y.-S., & Ng, H.-H. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.11.015 · Cited by 393
Xiao, L., Yuan, X., & Sharkis, S. J. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0299 · Cited by 353
Yu, J., & Thomson, J. A. (2008) · Genes & Development · doi:10.1101/gad.1689808 · Cited by 342
Metadata
- Authors
- Dahéron, L., Opitz, S. L., Zaehres, H., Lensch, W. M., Andrews, P. W., Itskovitz‐Eldor, J., & Daley, G. Q.
- Venue
- STEM CELLS
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-09
- Volume
- 22
- Issue
- 5
- Pages
- 770-778
- ISSN
- 1066-5099 (ISSN-L)
- 1549-4918
- OpenAlex
- W2060926602
- Cited by
- 470
- References
- 3
- FWCI
- 11.37
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Dahéron, L., Opitz, S. L., Zaehres, H., Lensch, W. M., Andrews, P. W., Itskovitz‐Eldor, J., & Daley, G. Q. (2004). LIF/STAT3 Signaling Fails to Maintain Self‐Renewal of Human Embryonic Stem Cells. STEM CELLS. https://doi.org/10.1634/stemcells.22-5-770
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