The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Stress Defense in Murine Embryonic Stem Cells Is Superior to That of Various Differentiated Murine Cells
Abstract
A very small number of embryonic stem (ES) cells gives rise to all tissues of the embryo proper. This means that ES cells should be equipped with highly efficient mechanisms to defend themselves against various stresses and to prevent or repair DNA damage. One of these mechanisms is a high activity of a verapamil-sensitive multidrug efflux pump. Because reactive oxygen species are a major source of DNA damage, we further tested the idea that murine ES cells might differ from their more differentiated counterparts by high levels of antioxidant defense and good DNA strand break repair capacity. This was confirmed by comparing cellular peroxide levels, total antioxidant capacity, and activity of radiation-induced strand break repair between murine ES cells and embryoid bodies or embryonic fibroblasts. Using microarrays and confirmation by reverse transcription-polymerase chain reaction, we identified several candidate antioxidant and stress-resistance genes that become downregulated during differentiation of ES cells into embryoid bodies.
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Cites
Kirkwood, T. B. L., & Austad, S. N. (2000) · Nature · doi:10.1038/35041682 · Cited by 1,774
Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence?
von Zglinicki, T., Saretzki, G., Döcke, W., & Lotze, C. (1995) · Experimental Cell Research · doi:10.1006/excr.1995.1305 · Cited by 856
Self-citationBmi1, stem cells, and senescence regulation
Park, I.-K., Morrison, S. J., & Clarke, M. F. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420800 · Cited by 495
HIF hydroxylation and the mammalian oxygen-sensing pathway
Safran, M., & Kaelin, W. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200318181 · Cited by 365
Mitochondrial oxidative stress causes chromosomal instability of mouse embryonic fibroblasts
Samper, E., Nicholls, D. G., & Melov, S. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00062.x · Cited by 108
Cited by
Understanding the odd science of aging
Kirkwood, T. B. L. (2005) · Cell · doi:10.1016/j.cell.2005.01.027 · Cited by 1,984
Jang, Y.-Y., & Sharkis, S. J. (2007) · Blood · doi:10.1182/blood-2007-05-087759 · Cited by 894
A continuous correlation between oxidative stress and telomere shortening in fibroblasts
Richter, T., & Zglinicki, T. V. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.08.005 · Cited by 321
Self-citationRadical medicine: treating ageing to cure disease
Finkel, T. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1763 · Cited by 234
Human Embryonic Stem Cells Have Enhanced Repair of Multiple Forms of DNA Damage
Maynard, S., Swistowska, A. M., Lee, J. W., Liu, Y., Liu, S.-T., Da Cruz, A. B., Rao, M., de Souza-Pinto, N. C., Zeng, X., & Bohr, V. A. (2008) · Stem Cells · doi:10.1634/stemcells.2007-1041 · Cited by 220
Metadata
- Authors
- Saretzki, G., Armstrong, L., Leake, A., Lako, M., & von Zglinicki, T.
- Venue
- STEM CELLS
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-11
- Volume
- 22
- Issue
- 6
- Pages
- 962-971
- ISSN
- 1066-5099 (ISSN-L)
- 1549-4918
- OpenAlex
- W2050560941
- Cited by
- 279
- References
- 5
- FWCI
- 2.95
- Type
- journal article
- Language
- en
- Open access
- closed
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- Saretzki, G., Armstrong, L., Leake, A., Lako, M., & von Zglinicki, T. (2004). Stress Defense in Murine Embryonic Stem Cells Is Superior to That of Various Differentiated Murine Cells. STEM CELLS. https://doi.org/10.1634/stemcells.22-6-962
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