Proautophagic Drugs: A Novel Means to Combat Apoptosis-Resistant Cancers, with a Special Emphasis on Glioblastomas

Radiotherapy Plus Concomitant and Adjuvant Temozolomide for Glioblastoma

Stupp, R., Mason, W. P., van den Bent, M. J., Weller, M., Fisher, B., Taphoorn, M. J. B., Belanger, K., Brandes, A. A., Marosi, C., Bogdahn, U., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043330 · Cited by 21,807

MGMT Gene Silencing and Benefit from Temozolomide in Glioblastoma

Hegi, M. E., Diserens, A.-C., Gorlia, T., Hamou, M.-F., de Tribolet, N., Weller, M., Kros, J. M., Hainfellner, J. A., Mason, W., Mariani, L., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043331 · Cited by 7,405

Self-eating and self-killing: crosstalk between autophagy and apoptosis

Maiuri, M. C., Zalckvar, E., Kimchi, A., & Kroemer, G. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2239 · Cited by 3,638

Induction of autophagy and inhibition of tumorigenesis by beclin 1

Liang, X. H., Jackson, S., Seaman, M., Brown, K., Kempkes, B., Hibshoosh, H., & Levine, B. (1999) · Nature · doi:10.1038/45257 · Cited by 3,347

Functions of Lysosomes

de Duve, C., & Wattiaux, R. (1966) · Annual Review of Physiology · doi:10.1146/annurev.ph.28.030166.002251 · Cited by 3,033 · cited 1×

Autophagy in Health and Disease: A Double-Edged Sword

Shintani, T., & Klionsky, D. J. (2004) · Science · doi:10.1126/science.1099993 · Cited by 2,559

The role of autophagy in cancer development and response to therapy

Kondo, Y., Kanzawa, T., Sawaya, R. A., & Kondo, S. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1692 · Cited by 1,673

Nuclear factor-κB

Aggarwal, B. B. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.09.003 · Cited by 1,586

Growth factor regulation of autophagy and cell survival in the absence of apoptosis

Lum, J. J., Bauer, D. E., Kong, M., Harris, M. H., Li, C., Lindsten, T., & Thompson, C. B. (2005) · Cell · doi:10.1016/j.cell.2004.11.046 · Cited by 1,487

Autophagy as a cell death and tumor suppressor mechanism

Gözüaçık, D., & Kimchi, A. (2004) · Oncogene · doi:10.1038/sj.onc.1207521 · Cited by 1,396

The catalytic phosphoinositol 3-kinase isoform p110δ is required for glioma cell migration and invasion

Luk, S. K., Piekorz, R. P., Nürnberg, B., & To, S. S. T. (2011) · European Journal of Cancer · doi:10.1016/j.ejca.2011.09.006 · Cited by 44

Differential Cytotoxic Activity of a Novel Palladium-Based Compound on Prostate Cell Lines, Primary Prostate Epithelial Cells and Prostate Stem Cells

Ulukaya, E., Frame, F. M., Cevatemre, B., Pellacani, D., Walker, H. F., Mann, V. M., Simms, M. S., Stower, M. J., Yılmaz, V. T., & Maitland, N. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064278 · Cited by 44

Anticancer Activity of Curcumin-Loaded PLGA Nanoparticles on PC3 Prostate Cancer Cells.

Azandeh, S., Abbaspour, M., Khodadadi, A., Khorsandi, L., Orazizadeh, M., & Heidari-Moghadam, A. (2017) · Europe PMC (PubMed Central) · Cited by 44

In vivo assessment of temozolomide local delivery for lung cancer inhalation therapy

Wauthoz, N., Deleuze, P., Hecq, J., Roland, I. H., Saussez, S., Adanja, I., Debeir, O., Decaestecker, C., Mathieu, V., Robert Kiss, A., et al. (2010) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2010.01.010 · Cited by 43

Autophagy‐mediated chemosensitization by cysteamine in cancer cells

Wan, X., Zheng, F., Zhang, L., Miao, Y., Man, N., & Wen, L. (2010) · International Journal of Cancer · doi:10.1002/ijc.25771 · Cited by 42

N-(2-{3-[3,5-Bis(trifluoromethyl)phenyl]ureido}ethyl)-glycyrrhetinamide (6b): A Novel Anticancer Glycyrrhetinic Acid Derivative that Targets the Proteasome and Displays Anti-Kinase Activity

Lallemand, B., Chaix, F., Bury, M., Bruyère, C., Ghostin, J., Becker, J., Delporte, C., Gelbcke, M., Mathieu, V., Dubois, J., et al. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm200285z · Cited by 42

Temozolomide-Based Dry Powder Formulations for Lung Tumor-Related Inhalation Treatment

Wauthoz, N., Deleuze, P., Saumet, A., Duret, C., Robert Kiss, A., & Amighi, K. (2010) · Pharmaceutical Research · doi:10.1007/s11095-010-0329-x · Cited by 42

Germacrone inhibits the proliferation of glioma cells by promoting apoptosis and inducing cell cycle arrest

LIU, B., Gao, Y., Wang, X., WANG, Y.-C., & Fu, L. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.2290 · Cited by 41

Essential Oil from Arnica Montana L. Achenes: Chemical Characteristics and Anticancer Activity

Sugier, D., Sugier, P., Jakubowicz-Gil, J., Winiarczyk, K., & Kowalski, R. (2019) · Molecules · doi:10.3390/molecules24224158 · Cited by 41

Neurotransmitters: Potential Targets in Glioblastoma

Huang, Q., Chen, L., Liang, J., Huang, Q., & Sun, H. (2022) · Cancers · doi:10.3390/cancers14163970 · Cited by 44

Role of BNIP3 in proliferation and hypoxia‐induced autophagy: implications for personalized cancer therapies

Azad, M. B., & Gibson, S. B. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05778.x · Cited by 41

Involvement of estrogen receptor β5 in the progression of glioma

Li, W., Winters, A., Poteet, E. C., Ryou, M., Lin, S., Hao, S., Wu, Z., Yuan, F., Hatanpaa, K. J., Simpkins, J. W., et al. (2013) · Brain Research · doi:10.1016/j.brainres.2013.02.004 · Cited by 38

Algae metabolites: from in vitro growth inhibitory effects to promising anticancer activity

Lefranc, F., Koutsaviti, A., Ioannou, E., Kornienko, A., Roussis, V., Robert Kiss, A., & Newman, D. J. (2018) · Natural Product Reports · doi:10.1039/c8np00057c · Cited by 36

Chemistry of the Nudibranch Aldisa andersoni: Structure and Biological Activity of Phorbazole Metabolites

Nuzzo, G., Ciavatta, M. L., Robert Kiss, A., Mathieu, V., Leclercqz, H., Manzo, E., Villani, G., Mollo, E., Lefranc, F., D’Souza, L., et al. (2012) · Marine Drugs · doi:10.3390/md10081799 · Cited by 38

Tenofovir disoproxil fumarate directly ameliorates liver fibrosis by inducing hepatic stellate cell apoptosis via downregulation of PI3K/Akt/mTOR signaling pathway

Lee, S. W., Kim, S. M., Hur, W., Kang, B.-Y., Lee, H. L., Nam, H., Yoo, S. H., Sung, P. S., Kwon, J. H., Jang, J. W., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0261067 · Cited by 40

PML-RAR&x03B1; enhances autophagic activity through inhibiting Akt/mTOR pathwayPreprint

Huang, Y., Hou, J., Chen, T., Zhao, X.-Y., Yan, Z.-W., Zhang, J., Yang, J., Kogan, S. C., & Chen, G. (2010) · Nature Precedings · doi:10.4161/auto.7.10.16636 · Cited by 39

Molecular mechanism underlying the anticancer effect of simvastatin on MDA-MB-231 human breast cancer cells

Shen, Y., Yuan, Y., Du, Y., & PAN, Y.-Y. (2012) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3411 · Cited by 36

Drug resistance in glioblastoma and cytotoxicity of seaweed compounds, alone and in combination with anticancer drugs: A mini review

Ferreira, J. S. P. D. M., Ramos, A. A., Almeida, T., Azqueta, A., & Rocha, E. (2018) · Phytomedicine · doi:10.1016/j.phymed.2018.04.062 · Cited by 35

Histone deacetylase 5 promotes the proliferation of glioma cells by upregulation of Notch 1

Liu, Q., Zheng, J., CHEN, J.-K., Yan, X., Chen, H., Nong, W., & Huang, H. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.2395 · Cited by 35

LAT1 targeted brain delivery of temozolomide and sorafenib for effective glioma therapy

Zhang, Y., Cheng, Q., Xue, Y., Yao, K., Syeda, M. Z., Xu, J., Wu, J., Wang, Z., Tang, L., & Mu, Q. (2023) · Nano Research · doi:10.1007/s12274-023-5568-3 · Cited by 34

Unveiling the Influence of Tumor Microenvironment and Spatial Heterogeneity on Temozolomide Resistance in Glioblastoma Using an Advanced Human In Vitro Model of the Blood‐Brain Barrier and Glioblastoma

Lam, M. S. Y., Aw, J., Tan, D., Vijayakumar, R., Lim, H. Y. G., Yada, S., Pang, Q. Y., Barker, N., Tang, C., Ang, B. T., et al. (2023) · Small · doi:10.1002/smll.202302280 · Cited by 34

Mechanisms of autophagy and apoptosis: Recent developments in breast cancer cells

Esteve, J. M. (2011) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v2.i10.232 · Cited by 35

N-Aryl-N′-(chroman-4-yl)ureas and thioureas display in vitro anticancer activity and selectivity on apoptosis-resistant glioblastoma cells: Screening, synthesis of simplified derivatives, and structure–activity relationship analysis

Goffin, E., Lamoral‐Theys, D., Tajeddine, N., Tullio, P. D., Mondin, L., Lefranc, F., Gailly, P. L., Rogister, B., Robert Kiss, A., & Pirotte, B. (2012) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2012.06.050 · Cited by 31

Rapamycin promotes differentiation increasing βIII-tubulin, NeuN, and NeuroD while suppressing nestin expression in glioblastoma cells

Ferrucci, M., Biagioni, F., Lenzi, P., Gambardella, S., Ferese, R., Calierno, M. T., Falleni, A., Grimaldi, A., Frati, A., Esposito, V., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.15906 · Cited by 31

Temozolomide encapsulated and folic acid decorated chitosan nanoparticles for lung tumor targeting: improving therapeutic efficacy both in vitro and in vivo

Li, K., Liang, N., Yang, H., Liu, H., & Li, S. (2017) · Oncotarget · doi:10.18632/oncotarget.22791 · Cited by 31

Chemical Characteristics and Anticancer Activity of Essential Oil from Arnica Montana L. Rhizomes and Roots

Sugier, P., Jakubowicz-Gil, J., Sugier, D., Kowalski, R., Gawlik‐Dziki, U., Kołodziej, B., & Dziki, D. (2020) · Molecules · doi:10.3390/molecules25061284 · Cited by 31

Galectin-1-mediated biochemical controls of melanoma and glioma aggressive behavior

Lefranc, F. (2011) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v2.i9.193 · Cited by 30

Mitochondrial dysfunction and effect of antiglycolytic bromopyruvic acid in GL15 glioblastoma cells

Macchioni, L., Davidescu, M., Sciaccaluga, M., Marchetti, C., Migliorati, G., Coaccioli, S., Roberti, R., Corazzi, L., & Castigli, E. (2011) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-011-9375-2 · Cited by 30

Autophagy-driven cell fate decision maker: Activated microglia induce specific death of glioma cells by a blockade of basal autophagic flux and secondary apoptosis/necrosis

Mora-Rodríguez, R. A., & Régnier‐Vigouroux, A. (2009) · Autophagy · doi:10.4161/auto.5.3.7881 · Cited by 30

Quantitative Ultrastructural Morphometry and Gene Expression of mTOR-Related Mitochondriogenesis within Glioblastoma Cells

Ferese, R., Lenzi, P., Fulceri, F., Biagioni, F., Fabrizi, C., Gambardella, S., Familiari, P., Frati, A., Limanaqi, F., & Fornai, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21134570 · Cited by 29

Transfection of a human glioblastoma cell line with liver‐type glutaminase ( LGA ) down‐regulates the expression of DNA ‐repair gene MGMT and sensitizes the cells to alkylating agents

Szeliga, M., Zgrzywa, A., Obara‐Michlewska, M., & Albrecht, J. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07917.x · Cited by 28

The potential roles of dopamine in malignant glioma

Lan, Y., Wang, X., Xing, J., Lou, J., Ma, X., & Zhang, B. (2016) · Acta Neurologica Belgica · doi:10.1007/s13760-016-0730-2 · Cited by 28

The role of mTOR during cisplatin treatment in an in vitro and ex vivo model of cervical cancer

Leisching, G. R., Loos, B., Botha, M. H., & Engelbrecht, A. (2015) · Toxicology · doi:10.1016/j.tox.2015.07.010 · Cited by 27

Immunohistochemical expression of MAP1LC3A and MAP1LC3B protein in breast carcinoma tissues

Othman, E. Q. G., Kaur, G., Mutee, A. F., Muhammad, T. S. T., & Tan, M. (2009) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.20309 · Cited by 27

Opposing roles of glutaminase isoforms in determining glioblastoma cell phenotype

Szeliga, M., & Albrecht, J. (2014) · Neurochemistry International · doi:10.1016/j.neuint.2014.11.004 · Cited by 26

Combination Therapy with AKT3 and PI3KCA siRNA Enhances the Antitumor Effect of Temozolomide and Carmustine in T98G Glioblastoma Multiforme Cells

Paul-Samojedny, M., Pudełko, A., Kowalczyk, M., Fila-Daniłow, A., Suchanek-Raif, R., Borkowska, P., & Kowalski, J. (2016) · BioDrugs · doi:10.1007/s40259-016-0160-y · Cited by 26

Considering temozolomide as a novel potential treatment for esophageal cancer

Bruyère, C., Lonez, C., Duray, A., Cludts, S., Ruysschaert, J., Saussez, S., Yeaton, P., Robert Kiss, A., & Mijatovic, T. (2010) · Cancer · doi:10.1002/cncr.25687 · Cited by 27

TLR9-ERK-mTOR signaling is critical for autophagic cell death induced by CpG oligodeoxynucleotide 107 combined with irradiation in glioma cells

Li, X., Cen, Y., Cai, Y., Liu, T., Liu, H., Cao, G., Liu, D., Li, B., Wei, P., Zou, J., et al. (2016) · Scientific Reports · doi:10.1038/srep27104 · Cited by 26

Chapter 14 Autophagy in Lung Cancer

Jaboin, J. J., Hwang, M., & Lu, J. (2009) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(08)04014-7 · Cited by 26

NETRIN-4 Protects Glioblastoma Cells FROM Temozolomide Induced Senescence

Li, L., Hu, Y., Ylivinkka, I., Li, H., Chen, P., Keski‐Oja, J., & Hyytiäinen, M. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080363 · Cited by 26

Redox Regulation of Autophagy in Cancer: Mechanism, Prevention and Therapy

He, J., Dong, L., Luo, L., & Wang, K. (2022) · Life · doi:10.3390/life13010098 · Cited by 26

Kinetic studies of the effects of Temodal and quercetin on astrocytoma cells

Jakubowicz-Gil, J., Langner, E., & Rzeski, W. (2011) · Pharmacological Reports · doi:10.1016/s1734-1140(11)70506-0 · Cited by 25

Can hsp90α-Targeted siRNA Combined With TMZ Be a Future Therapy for Glioma?

Cruickshanks, N. A., Shervington, L. A., Patel, R., Munje, C., Thakkar, D., & Shervington, A. A. (2010) · Cancer Investigation · doi:10.3109/07357901003630967 · Cited by 25

Evaluation of chemopreventive potentials of ethanolic extract of Ruta graveolens against A375 skin melanoma cells in vitro and induced skin cancer in mice in vivo

Ghosh, S., Sikdar, S., Mukherjee, A., & Khuda‐Bukhsh, A. R. (2015) · Journal of Chinese Integrative Medicine · doi:10.1016/s2095-4964(15)60156-x · Cited by 25

Necroptosis: A novel therapeutic target for glioblastoma

Jiang, Y., Peng, Y., & Koussougbo, K. S. (2010) · Medical Hypotheses · doi:10.1016/j.mehy.2010.10.037 · Cited by 25

Mechanism of thalidomide to enhance cytotoxicity of temozolomide in U251-MG glioma cells in vitro.

Gao, S., Yang, X., Zhang, W.-G., Ji, Y., & Pan‐Hammarström, Q. (2009) · PubMed · Cited by 25

New dry powders for inhalation containing temozolomide-based nanomicelles for improved lung cancer therapy.

Rosière, R., Gelbcke, M., Mathieu, V., Antwerpen, P. V., Amighi, K., & Wauthoz, N. (2015) · International Journal of Oncology · doi:10.3892/ijo.2015.3092 · Cited by 24

Taxifolin Targets PI3K and mTOR and Inhibits Glioblastoma Multiforme

Yao, W., Gong, H., Mei, H., Shi, L., Yu, J., & Hu, Y. (2021) · Journal of Oncology · doi:10.1155/2021/5560915 · Cited by 24

BC3EE2,9B, a synthetic carbazole derivative, upregulates autophagy and synergistically sensitizes human GBM8901 glioblastoma cells to temozolomide

CHEN, C.-M., Syu, J.-P., Way, T., Huang, L., Kuo, S., Lin, C., & Lin, C. (2015) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2015.2332 · Cited by 24

Modulating autophagy: a strategy for cancer therapy

Li, J.-L., Han, S., & Fan, X. (2011) · 癌症：英文版 · doi:10.5732/cjc.011.10185 · Cited by 23

Quinacrine synergistically enhances the antivascular and antitumor efficacy of cediranib in intracranial mouse glioma

Lobo, M. R., Green, S. C., Schabel, M. C., Gillespie, G. Y., Woltjer, R. L., & Pike, M. M. (2013) · Neuro-Oncology · doi:10.1093/neuonc/not119 · Cited by 23

Pharmacological enhancement of autophagy induced in a hepatocellular carcinoma cell line by high-LET radiation.

Altmeyer, A., Jung, A. C., Ignat, M., Benzina, S., Denis, J.-M., Gueulette, J., Noël, G., Mutter, D., & Bischoff, P. L. (2010) · PubMed · Cited by 22

The Anticancer Activity of Monosaccharides: Perspectives and Outlooks

McCallum, N., & Najlah, M. (2024) · Cancers · doi:10.3390/cancers16162775 · Cited by 21

Anti‐tumour efficacy on glioma models of PHA ‐848125, a multi‐kinase inhibitor able to cross the blood–brain barrier

Albanese, C., Alzani, R., Amboldi, N., Degrassi, A., Festuccia, C., Fiorentini, F., Gravina, G. L., Mercurio, C., Pastori, W., Brasca, M. G., et al. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12112 · Cited by 22

Bromopyruvate mediates autophagy and cardiolipin degradation to monolyso-cardiolipin in GL15 glioblastoma cells

Davidescu, M., Sciaccaluga, M., Macchioni, L., Angelini, R., Lopalco, P., Rambotti, M. G., Roberti, R., Corcelli, A., Castigli, E., & Corazzi, L. (2012) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-012-9411-x · Cited by 21

Tetrandrine and Caffeine Modulated Cell Cycle and Increased Glioma Cell Death via Caspase-Dependent and Caspase-Independent Apoptosis Pathways

Chen, J.-C., Hwang, J.-H., Chiu, W.-H., & Chan, Y. (2014) · Nutrition and Cancer · doi:10.1080/01635581.2014.902974 · Cited by 21

Decreased APE-1 by Nitroxoline Enhances Therapeutic Effect in a Temozolomide-resistant Glioblastoma: Correlation with Diffusion Weighted Imaging

Cho, H. R., Kumari, N., Thakur, N., Vu, H. T., Kim, H., & Choi, S. H. (2019) · Scientific Reports · doi:10.1038/s41598-019-53147-9 · Cited by 20

Apoptotic Effects of Physalis minima L. Chloroform Extract in Human Breast Carcinoma T-47D Cells Mediated by c-myc-, p53-, and Caspase-3-Dependent Pathways

Ooi, K. L., Muhammad, T. S. T., Lim, C. H., & Sulaiman, S. F. (2010) · Integrative Cancer Therapies · doi:10.1177/1534735409356443 · Cited by 20

Phosphorylated mammalian target of rapamycin expression is associated with the response to chemoradiotherapy in patients with esophageal squamous cell carcinoma

Li, S.-H., Huang, E., Lu, H., Huang, W., Yen, C., Huang, W., & Chen, C. (2012) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2012.06.049 · Cited by 20

Is there a common upstream link for autophagic and apoptotic cell death in human high-grade gliomas?

Emdad, L., Qadeer, Z. A., Bederson, L., Kothari, H. P., Uzzaman, M., & Germano, I. M. (2011) · Neuro-Oncology · doi:10.1093/neuonc/nor053 · Cited by 20

Potential anticancer activity of young Carpinus betulus leaves

Cieckiewicz, E., Angenot, L. J. G., Gras, T., Robert Kiss, A., & Frédérich, M. (2011) · Phytomedicine · doi:10.1016/j.phymed.2011.09.072 · Cited by 20

Ardipusilloside I induces apoptosis in human glioblastoma cells through a caspase-8-independent FasL/Fas-signaling pathway

Xiong, J., Cheng, G., Tang, H., Zhen, H., & Zhang, X. (2008) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2008.11.008 · Cited by 19

Characterization and comparison of perezone with some analogues. Experimental and theoretical study

Escobedo-González, R. G., Córdova-Bahena, L., Tellez, J. L. A., Hinojosa-Torres, J., Ruvalcaba, R. M., & Aceves-Hernández, J. M. (2015) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2015.05.016 · Cited by 19

4-Bromo-2-(piperidin-1-yl)thiazol-5-yl-phenyl methanone (12b) inhibits Na+/K+-ATPase and Ras oncogene activity in cancer cells

Lefranc, F., Xu, Z., Burth, P., Mathieu, V., Revelant, G., Faria, M. V. D. C., Noyon, C., Garcia, D. G., Dufour, D., Bruyère, C., et al. (2013) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2013.01.046 · Cited by 20

JLK1486, a Bis 8-Hydroxyquinoline-Substituted Benzylamine, Displays Cytostatic Effects in Experimental Gliomas through MyT1 and STAT1 Activation and, to a Lesser Extent, PPARγ Activation

Bruyère, C., Madonna, S., Goietsenoven, G. V., Mathieu, V., Dessolin, J., Kraus, J., Lefranc, F., & Robert Kiss, A. (2011) · Translational Oncology · doi:10.1593/tlo.10253 · Cited by 18

EMAP-II sensitize U87MG and glioma stem-like cells to temozolomide via induction of autophagy-mediated cell death and G2/M arrest

Yu, Q., Liu, L., Wang, P., Yao, Y., Xue, Y., & Liu, Y. (2017) · Cell Cycle · doi:10.1080/15384101.2017.1315492 · Cited by 17

Perezone and its isomer isoperezone induce caspase-dependent and caspase-independent cell death

Sánchez‐Torres, L. E., Martínez, J. O., Godínez‐Victoria, M., Omar, J., & Velasco‐Bejarano, B. (2010) · Phytomedicine · doi:10.1016/j.phymed.2009.12.011 · Cited by 17

Rola autofagii w komórkach nowotworowych: charakterystyka wzajemnych zależności pomiędzy procesami autofagii i apoptozy; modulacja autofagii jako nowa strategia terapeutyczna w leczeniu glejaków

Ciechomska, I. A. (2018) · Postępy Biochemii · doi:10.18388/pb.2018_121 · Cited by 16

Growth arrest and induction of apoptotic and non-apoptotic programmed cell death by, Physalis minima L. chloroform extract in human ovarian carcinoma Caov-3 cells

Ooi, K. L., Muhammad, T. S. T., & Sulaiman, S. F. (2010) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2009.12.032 · Cited by 16

Cell death after high-LET irradiation in orthotopic human hepatocellular carcinoma in vivo.

Altmeyer, A., Ignat, M., Denis, J.-M., Messaddeq, N., Gueulette, J., Mutter, D., & Bischoff, P. L. (2011) · PubMed · Cited by 16

Autophagy flux inhibition, G2/M cell cycle arrest and apoptosis induction by ubenimex in glioma cell lines

Han, L., Zhang, Y., Liu, S., Zhao, Q., Liang, X., Ma, Z., Gupta, P. K., Zhao, M., & Wang, A. (2017) · Oncotarget · doi:10.18632/oncotarget.22594 · Cited by 16

Trivanillic polyphenols with anticancer cytostatic effects through the targeting of multiple kinases and intracellular Ca2+release

Lamoral‐Theys, D., Wauthoz, N., Heffeter, P., Mathieu, V., Jungwirth, U., Lefranc, F., Nève, J., Dubois, J., Dufrasne, F., Amighi, K., et al. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01403.x · Cited by 15

Melatonin Exerts Anticancer Effects in Human Tongue Squamous Cell Carcinoma Cells by Promoting Autophagy

Sung, E., Kim, J., Ahn, Y. T., Lee, I., Choi, S., Jang, H. B., Lee, J., & An, W. G. (2020) · Anticancer Research · doi:10.21873/anticanres.14650 · Cited by 15

Oral azithromycin versus its combination with miltefosine for the treatment of experimental Old World cutaneous leishmaniasis

Amer, E. I., Eissa, M. M., & Mossallam, S. F. (2014) · Journal of Parasitic Diseases · doi:10.1007/s12639-014-0529-0 · Cited by 15

The anti-tumor effects of Celastrus orbiculatus Thunb. and its monomer composition: A review

Feng, X., Yin, Z., Ou, S., Chu, Z., Feng, J., Luo, Y., Hu, Y., Liu, Y., Jiang, W., Wang, X., et al. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116363 · Cited by 16

Knockdown of AKT3 and PI3KCA by RNA interference changes the expression of the genes that are related to apoptosis and autophagy in T98G glioblastoma multiforme cells

Paul-Samojedny, M., Pudełko, A., Kowalczyk, M., Fila-Daniłow, A., Suchanek-Raif, R., Borkowska, P., & Kowalski, J. (2015) · Pharmacological Reports · doi:10.1016/j.pharep.2015.04.012 · Cited by 14

The combination of antitumor drugs, exemestane and erlotinib, induced resistance mechanism in H358 and A549 non-small cell lung cancer (NSCLC) cell lines

Kritikou, I., Giannopoulou, E., Koutras, A. K., Labropoulou, V., & Kalofonos, H. P. (2013) · Pharmaceutical Biology · doi:10.3109/13880209.2013.841718 · Cited by 14

DHL-TauZnNa, a newly synthesized α-lipoic acid derivative, induces autophagy in human colorectal cancer cells

Hiratsuka, T., Inomata, M., Kono, Y., Yokoyama, S., Shiraishi, N., & Kitano, S. (2013) · Oncology Reports · doi:10.3892/or.2013.2394 · Cited by 13

The PYK2 inhibitor PF-562271 enhances the effect of temozolomide on tumor growth in a C57Bl/6-Gl261 mouse glioma model

Ortiz-Rivera, J., Nuñez, R. E., Kucheryavykh, Y. V., & Kucheryavykh, L. Y. (2023) · Journal of Neuro-Oncology · doi:10.1007/s11060-023-04260-3 · Cited by 12

A panel of eight autophagy-related long non-coding RNAs is a good predictive parameter for clear cell renal cell carcinoma

Gui, C., Cao, J., Tan, L., Huang, Y., Tang, Y., Li, P.-J., Chen, Y., Lu, J. K., Yao, H., Chen, Z., et al. (2021) · Genomics · doi:10.1016/j.ygeno.2021.01.016 · Cited by 12

Combined Efficacy of Cediranib and Quinacrine in Glioma Is Enhanced by Hypoxia and Causally Linked to Autophagic Vacuole Accumulation

Lobo, M. R., Wang, X., Gillespie, G. Y., Woltjer, R. L., & Pike, M. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0114110 · Cited by 12

Alterations to the structure of Leishmania major induced by N-arylisoquinolines correlate with compound accumulation and disposition

Ponte‐Sucre, A., Gulder, T., Gulder, T. A. M., Vollmers, G., Bringmann, G., & Moll, H. (2009) · Journal of Medical Microbiology · doi:10.1099/jmm.0.014241-0 · Cited by 11

Glioblastoma-derived cells in vitro unveil the spectrum of drug resistance capability – comparative study of tumour chemosensitivity in different culture systems

Witusik‐Perkowska, M., Zakrzewska, M., Sikorska, B., Papierz, W., Jaskólski, D. J., Szemraj, J., & Liberski, P. P. (2017) · Bioscience Reports · doi:10.1042/bsr20170058 · Cited by 11

Role of Autophagy in the Ovary Cell Death in Mammals

Escobar, M. L., Echeverría, O. M., & Vázquez‐Nin, G. H. (2013) · InTech eBooks · doi:10.5772/54777 · Cited by 10

Editorial: on the road to multi-modal and pluri-disciplinary treatment of glioblastomas

Lefranc, F. (2009) · Acta Neurochirurgica · doi:10.1007/s00701-009-0185-9 · Cited by 10

Calcium dependence of purinergic subtype P2Y1 receptor modulation of C6 glioma cell migration

Jantaratnotai, N., & McLarnon, J. G. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.04.034 · Cited by 9

Long non-coding RNA CASC2 targeting miR-18a suppresses glioblastoma cell growth, metastasis and EMT in vitro and in vivo

Wang, J., Qin, C., Chen, Z., Wen, Y. H., Ke, S., & Liao, B. (2020) · Journal of Biosciences · doi:10.1007/s12038-020-00077-8 · Cited by 9

Fatsioside A inhibits the growth of glioma cells via the induction of endoplasmic reticulum stress-mediated apoptosis

Pan, J., Zhou, L., Wang, G., XIA, G.-W., Xue, K., Cui, X., SHI, H.-Z., Liu, J., & Hu, J. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3213 · Cited by 8

Kinase Inhibitors Involved in the Regulation of Autophagy: Molecular Concepts and Clinical Implications

Al‐Huseini, I., Sirasanagandla, S. R., Babu, K. S., Sofin, R. G. S., & Das, S. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220117114306 · Cited by 8

Alternative responses of primary tumor cells and glioblastoma cell lines to N,N-bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines: Cell death versus P53-independent senescence

Beclin (2010) · International Journal of Oncology · doi:10.3892/ijo_00000798 · Cited by 8

Paclitaxel-Induced G2/M Arrest via Different Mechanism of Actions in Glioma Cell Lines with Differing p53 Mutational Status

Han, B., & Lee, M. (2015) · International Journal of Pharmacology · doi:10.3923/ijp.2016.19.27 · Cited by 8

Signaling Pathways in Gliomas

Stachyra, P., & Grzybowska-Szatkowska, L. (2025) · Genes · doi:10.3390/genes16050600 · Cited by 8

Evaluation of the anticancer activities of two fungal polycyclic ethanones, alternethanoxins A and B, and two of their derivatives

Kiss (2010) · International Journal of Oncology · doi:10.3892/ijo_00000842 · Cited by 7

RECQ1 Promotes Stress Resistance and DNA Replication Progression Through PARP1 Signaling Pathway in Glioblastoma

Zhang, J., Lian, H., Chen, K., Pang, Y. K., Chen, M., Huang, B., Zhu, L., Xu, S., Liu, M., & Zhong, C. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.714868 · Cited by 7

Update on the effects of the sodium pump α1 subunit on human glioblastoma: from the laboratory to the clinic

Lan, Y., Yu, Z., Lou, J., Ma, X., & Zhang, B. (2018) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2018.1512582 · Cited by 6

Autophagy, new perspectives in anticancer therapy

Lisiak, N., Totoń, E., & Rybczyńska, M. (2014) · Postępy Higieny i Medycyny Doświadczalnej · doi:10.5604/17322693.1111361 · Cited by 6

Targeted therapy of glioblastomas: a 5-year view

Djedid, R., Robert Kiss, A., & Lefranc, F. (2009) · Therapy · doi:10.2217/thy.09.12 · Cited by 6

Autophagy: A strategy for malignant gliomas’ resistance to therapy

Ge, P., Luo, Y., Fu, S., Ji, X., & Ling, F. (2009) · Medical Hypotheses · doi:10.1016/j.mehy.2008.11.047 · Cited by 6

Autophagy-mediated growth inhibition of malignant glioma cells by the BH3-mimetic gossypol

Kim, N.-Y., & Lee, M. (2014) · Molecular & Cellular Toxicology · doi:10.1007/s13273-014-0017-8 · Cited by 5

Autophagic and Apoptotic Pathways as Targets for Chemotherapy in Glioblastoma

Trejo‐Solís, C., Serrano‐García, N., Escamilla-Ramírez, Á., Castillo‐Rodríguez, R. A., Jiménez‐Farfán, D., Palencia, G., Calvillo, M., Lemus, M. A. A., Flores‐Nájera, A., Cruz-Salgado, A., et al. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123773 · Cited by 87

Therapeutic Exploitation of Apoptosis and Autophagy for Glioblastoma

Kögel, D., Fulda, S., & Mittelbronn, M. G. A. (2010) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520611009060438 · Cited by 53

Role of autophagy in therapeutic resistance of glioblastoma

Chien, C.-H., Hsueh, W., Chuang, J., & Chang, K. (2019) · Journal of Cancer Metastasis and Treatment · doi:10.20517/2394-4722.2019.016 · Cited by 15

Autophagy, the Trojan horse to combat glioblastomas

Lefranc, F., & Kiss, R. (2006) · Neurosurgical FOCUS · doi:10.3171/foc.2006.20.4.4 · Cited by 126

Autophagy machinery in glioblastoma: The prospect of cell death crosstalk and drug resistance with bioinformatics analysis

Qin, Y., Xiong, S., Ren, J. T., & Sethi, G. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216482 · Cited by 17