Proautophagic Drugs: A Novel Means to Combat Apoptosis-Resistant Cancers, with a Special Emphasis on Glioblastomas

Radiotherapy Plus Concomitant and Adjuvant Temozolomide for Glioblastoma

Stupp, R., Mason, W. P., van den Bent, M. J., Weller, M., Fisher, B., Taphoorn, M. J. B., Belanger, K., Brandes, A. A., Marosi, C., Bogdahn, U., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043330 · Cited by 21,807

MGMT Gene Silencing and Benefit from Temozolomide in Glioblastoma

Hegi, M. E., Diserens, A.-C., Gorlia, T., Hamou, M.-F., de Tribolet, N., Weller, M., Kros, J. M., Hainfellner, J. A., Mason, W., Mariani, L., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043331 · Cited by 7,405

Self-eating and self-killing: crosstalk between autophagy and apoptosis

Maiuri, M. C., Zalckvar, E., Kimchi, A., & Kroemer, G. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2239 · Cited by 3,638

Induction of autophagy and inhibition of tumorigenesis by beclin 1

Liang, X. H., Jackson, S., Seaman, M., Brown, K., Kempkes, B., Hibshoosh, H., & Levine, B. (1999) · Nature · doi:10.1038/45257 · Cited by 3,347

Functions of Lysosomes

de Duve, C., & Wattiaux, R. (1966) · Annual Review of Physiology · doi:10.1146/annurev.ph.28.030166.002251 · Cited by 3,033 · cited 1×

Autophagy in Health and Disease: A Double-Edged Sword

Shintani, T., & Klionsky, D. J. (2004) · Science · doi:10.1126/science.1099993 · Cited by 2,559

The role of autophagy in cancer development and response to therapy

Kondo, Y., Kanzawa, T., Sawaya, R. A., & Kondo, S. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1692 · Cited by 1,673

Nuclear factor-κB

Aggarwal, B. B. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.09.003 · Cited by 1,586

Growth factor regulation of autophagy and cell survival in the absence of apoptosis

Lum, J. J., Bauer, D. E., Kong, M., Harris, M. H., Li, C., Lindsten, T., & Thompson, C. B. (2005) · Cell · doi:10.1016/j.cell.2004.11.046 · Cited by 1,487

Autophagy as a cell death and tumor suppressor mechanism

Gözüaçık, D., & Kimchi, A. (2004) · Oncogene · doi:10.1038/sj.onc.1207521 · Cited by 1,396

New Pt-NNSO core anticancer agents: Structural optimization and investigation of their anticancer activity

Chong, S. X., Jin, Y., Au‐Yeung, S. C. F., & To, K. K. W. (2017) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2017.02.002 · Cited by 5

Gymnema sylvestre Extract Restores the Autophagic Pathway in Human Glioblastoma Cells U87Mg

Rotondo, R., Castaldo, S., Oliva, M. A., & Arcella, A. (2021) · Biology · doi:10.3390/biology10090870 · Cited by 4

Effect of polygodial and its direct derivatives on the mammalian Na + /K + -ATPase activity

Garcia, D. G., Gonçalves-de-Albuquerque, C. F., da Silva, C. I., Robert Kiss, A., Dasari, R., Chandra, S., Kornienko, A., & Burth, P. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.04.031 · Cited by 3

Mechanisms of cell resistance in glioblastoma multiforme

Sarafian, V. S. (2010) · Journal of IMAB - Annual Proceeding (Scientific Papers) · doi:10.5272/jimab.1512009_6 · Cited by 4

Apoptotic, Autophagic and Necrotic Cell Death Types in Pathophysiological Conditions: Morphological and Histological Aspects

D'Herde, K. G. M. A., Diez‐Fraile, A., & Lammens, T. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9293-0_2 · Cited by 4

The development of cytotoxic chemotherapeutics in the twentieth century

TEMEL, M. K. (2015) · Turkish Journal of Oncology · doi:10.5505/tjoncol.2015.1151 · Cited by 4

Phenoxyaromatic Acid Analogues as Novel Radiotherapy Sensitizers: Design, Synthesis and Biological Evaluation

Zhang, H., Wen, C., Li, B., Yan, X., Xu, Y., Guo, J., Shi, H., Chang, J., Li, S., & Xiao, J. (2022) · Molecules · doi:10.3390/molecules27082428 · Cited by 3

The Role of Autophagy in Childhood Central Nervous System Tumors

Wang, Y., Xu, Y., & Zhu, C. (2022) · Current Treatment Options in Oncology · doi:10.1007/s11864-022-01015-6 · Cited by 3

Plant-Derived Isoprenoids Mediate Regulation of mTOR Signaling in Tumor Cells

Peffley, D. M., & Hentosh, P. (2012) · Springer eBooks · doi:10.1007/978-94-007-4575-9_15 · Cited by 3

Celastrol with a Knockdown of miR-9-2, miR-17 and miR-19 Causes Cell Cycle Changes and Induces Apoptosis and Autophagy in Glioblastoma Multiforme Cells

Paul-Samojedny, M., Liduk, E., Borkowska, P., Zielińska, A., Kowalczyk, M., Suchanek-Raif, R., & Kowalski, J. (2022) · Processes · doi:10.3390/pr10030441 · Cited by 2

The Role of Pyk2 Kinase in Glioblastoma Progression and Therapeutic Targeting

Kucheryavykh, L. Y., & Kucheryavykh, Y. V. (2025) · Cancers · doi:10.3390/cancers17162611 · Cited by 2

The chemosensitizing effect of aqueous extract of sweet fennel on cisplatin treated HeLa cells

Ramadan, W. S., Sait, K., Anfinan, N. M., & Sait, H. (2016) · Clinical and Experimental Obstetrics & Gynecology · doi:10.12891/ceog2125.2016 · Cited by 2

4-Nerolidylcatechol induces autophagy in human glioblastoma cells

Massaro, R. R., Brohem, C. A., de Almeida, R. L., Rivelli, D. P., Miyake, J. A., Colquhoun, A., Barros, S. B. D. M., & Maria–Engler, S. S. (2018) · Brazilian Journal of Pharmaceutical Sciences · doi:10.1590/s2175-97902017000300169 · Cited by 2

Molecular Pathways of Different Types of Cell Death: Many Roads to Death

Krysko, D. V., Kaczmarek, A., & Vandenabeele, P. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9293-0_1 · Cited by 2

Drug-Resistant Glioma: Treatment with Imatinib Mesylate and Chlorimipramine

Bılır, A., & Ergüven, M. (2011) · Springer eBooks · doi:10.1007/978-94-007-0344-5_26 · Cited by 1

Autophagy in Glioma Cells

Ciechomska, I. A., Ellert‐Miklaszewska, A., & Kaminska, B. (2014) · Springer eBooks · doi:10.1007/978-3-7091-1431-5_5 · Cited by 1

Modifications in plasma membrane lipid composition and morphological features of AH-130 hepatoma cells by polyenylphosphatidylcholine in vivo treatment

Cinosi, V. (2011) · Oncology Reports · doi:10.3892/or.2011.1272 · Cited by 1

Targeting autophagy: do patents reveal a therapeutic potential?

Lefranc, F., Ingrassia, L., & Robert Kiss, A. (2008) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.18.8.813 · Cited by 1

Schidandrin B kills tumor cells by initiating apoptosis in glioma SHG-44 cells

Qi, L., Yu, H., Li, Y., Jin, H. Y., Zhao, D., & Xu, Y. (2016) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-015-2406-9 · Cited by 1

Endoplasmic Reticulum Stress and Autophagy in Cancer

Tan, M., Tan, H. K., & Muhammad, T. S. T. (2020) · Springer eBooks · doi:10.1007/978-3-030-30845-2_18 · Cited by 1

Microvesicles Derived from Human Placental Mesenchymal Stem Cells Induce Autophagy and Apoptosis in Acute Myeloid Leukemia

Khanmiri, J. M., Mousavi, S. H., Alizadeh, S., & Khani-Eshratabadi, M. (2023) · Journal of Advances in Medical and Biomedical Research · doi:10.30699/jambs.31.149.574 · Cited by 1

Genetic Signaling in Glioblastoma Multiforme (GBM): A Current Overview

Lukiw, W. J., & Culicchia, F. (2010) · Advances in neurobiology · doi:10.1007/978-1-4419-7104-3_24 · Cited by 1

Enhancement of Cell Death in High-Grade Glioma Cells

Tiwari, M., Sharma, L. K., & Godbole, M. M. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-405530-8.00016-9 · Cited by 1

Facile synthesis of autophagonizer and evaluation of its activity to induce autophagic cell death in apoptosis-defective cell line

Nguyen, J., Chen, L., Kumar, D., & Lee, J. (2016) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2016.08.035 · Cited by 1

Drug Combinations as a Therapeutic Approach for mTORC1 Inhibitors in Human Cancer

Breuleux, M., & Lane, H. A. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-271-1_8 · Cited by 1

A redução de DDB2 está relacionada ao pior prognóstico de sobrevida dos pacientes com glioma e a maior agressividade de células U138MG

de Sousa, J. F. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2018.tde-19072018-152637 · Cited by 1

Combining oncolytic immunotherapy with conventional cancer treatments

Liikanen, I. (2015) · Työväentutkimus Vuosikirja

The Biological Role of mTOR in the Pathogenesis of Solid Tumors: An Overview

Koropouli, E., Manolopoulos, L., Pandha, H., & Syrigos, K. (2009) · Current Enzyme Inhibition · doi:10.2174/157340809787314274

The Role of BNIP3 in Proliferation and Hypoxia-Induced Autophagy: Implications for Cancer Therapy

Azad, M. B. (2010) · Mspace (University of Manitoba)

Preclinical Study of Potential Antiglioma Novel Tetrahydroisoquinoline Analogs: Pharmacokinetics and Mechanism of Action10.21007/etd.cghs.2012.0191

Ma, F. (2012) · doi:10.21007/etd.cghs.2012.0191

Insights into the Molecular Role of Endocannabinoids in Diabetes Mellitus

(2021) · Biointerface Research in Applied Chemistry · doi:10.33263/briac121.470485

Study on the Sensitivity of Long Non-Coding RNA-HOTAIR to Radiotherapy for Malignant Tumors

肖, 雪. (2023) · Advances in Clinical Medicine · doi:10.12677/acm.2023.132335

Data from Oncogenic B-RAF Signaling in Melanoma Impairs the Therapeutic Advantage of Autophagy Inhibition

Armstrong, J. L., Corazzari, M., Martin, S., Pagliarini, V., Falasca, L., Hill, D. S., Ellis, N., Sabah, S. A., Redfern, C. P. F., Fimia, G. M., et al. (2023) · doi:10.1158/1078-0432.c.6519183.v1

Etude des réponses induites par l’erlotinib dans des cellules de lignées de glioblastome

Eimer, S. (2011) · theses.fr (ABES) · doi:10.70675/48cf26bbz6b1cz4672za2d5zc83a7ce5752a

Design of 4-(piperazin-1-yl)thieno[2,3-d]pyrimidine derivatives targeting the DFG-out conformation of VEGFR-2: Synthesis, biological evaluations, and molecular modeling approaches

Saleh, A. M., Eldehna, W. M., Elnagar, M. R., Elmasry, G. F., Abdelrahman, M. A., El‐Zahabi, M. A., & Abou‐Seri, S. M. (2026) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2026.119401

BindingDB Entry 50043000: Therapeutic agents triggering nonapoptotic cancer cell death.

BindingDB (2014) · UC San Diego · doi:10.7270/q2d2200s

Autophagy and Necroptosis in Cancer

Tan, M., Tan, H. K., Moad, A. I. H., & Muhammad, T. S. T. (2014) · Springer eBooks · doi:10.1007/978-3-662-44006-3_14

Autophagic and Apoptotic Pathways as Targets for Chemotherapy in Glioblastoma

Trejo‐Solís, C., Serrano‐García, N., Escamilla-Ramírez, Á., Castillo‐Rodríguez, R. A., Jiménez‐Farfán, D., Palencia, G., Calvillo, M., Lemus, M. A. A., Flores‐Nájera, A., Cruz-Salgado, A., et al. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123773 · Cited by 87

Therapeutic Exploitation of Apoptosis and Autophagy for Glioblastoma

Kögel, D., Fulda, S., & Mittelbronn, M. G. A. (2010) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520611009060438 · Cited by 53

Role of autophagy in therapeutic resistance of glioblastoma

Chien, C.-H., Hsueh, W., Chuang, J., & Chang, K. (2019) · Journal of Cancer Metastasis and Treatment · doi:10.20517/2394-4722.2019.016 · Cited by 15

Autophagy, the Trojan horse to combat glioblastomas

Lefranc, F., & Kiss, R. (2006) · Neurosurgical FOCUS · doi:10.3171/foc.2006.20.4.4 · Cited by 126

Autophagy machinery in glioblastoma: The prospect of cell death crosstalk and drug resistance with bioinformatics analysis

Qin, Y., Xiong, S., Ren, J. T., & Sethi, G. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216482 · Cited by 17