The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
VEGF Receptor Signaling in Tumor Angiogenesis
Open accessAbstract
The growth of human tumors and development of metastases depend on the de novo formation of blood vessels. The formation of new blood vessels is tightly regulated by specific growth factors that target receptor tyrosine kinases (RTKs). Vascular endothelial growth factor (VEGF) and the Flk-1/KDR RTK have been implicated as the key endothelial cell-specific factor signaling pathway required for pathological angiogenesis, including tumor neovascularization. Inhibition of the VEGF tyrosine kinase signaling pathway blocks new blood vessel formation in growing tumors, leading to stasis or regression of tumor growth. Advances in understanding the biology of angiogenesis have led to the development of several therapeutic modalities for the inhibition of the VEGF tyrosine kinase signaling pathway. A number of these modalities are under investigation in clinical studies to evaluate their potential to treat human cancers.
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Increased Vascularization in Mice Overexpressing Angiopoietin-1
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Cited by
Cross, M. J., & Claesson-Welsh, L. (2001) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01676-x · Cited by 989
Diverging inflammasome signals in tumorigenesis and potential targeting
Karki, R., & Kanneganti, T.-D. (2019) · Nature Reviews Cancer · doi:10.1038/s41568-019-0123-y · Cited by 641
Immunosuppressive Therapy and Malignancy in Organ Transplant Recipients: A Systematic Review
Gutierrez-Dalmau, A., & Campistol, J. M. (2007) · Drugs · doi:10.2165/00003495-200767080-00006 · Cited by 408
A DNA vaccine against VEGF receptor 2 prevents effective angiogenesis and inhibits tumor growth
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Targeting cellular pathways in glioblastoma multiforme
Pearson, J. R. D., & Regad, T. (2017) · Signal Transduction and Targeted Therapy · doi:10.1038/sigtrans.2017.40 · Cited by 344
Metadata
- Authors
- McMahon, G.
- Venue
- The Oncologist
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-04-01
- Volume
- 5
- Issue
- 90001
- Pages
- 3-10
- ISSN
- 1083-7159 (ISSN-L)
- 1549-490X
- OpenAlex
- W2102140960
- Cited by
- 519
- References
- 5
- FWCI
- 6.42
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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