The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Incidence of Acute Myeloid Leukemia and Hepatocellular Carcinoma in Mice Irradiated with 1 GeV/nucleon56Fe Ions
Abstract
Estimates of cancer risks posed to space-flight crews by exposure to high atomic number, high-energy (HZE) ions are subject to considerable uncertainty because epidemiological data do not exist for human populations exposed to similar radiation qualities. We assessed the leukemogenic efficacy of one such HZE species, 1 GeV (56)Fe ions, a component of space radiation, in a mouse model for radiation-induced acute myeloid leukemia. CBA/CaJ mice were irradiated with 1 GeV/nucleon (56)Fe ions or (137)Cs gamma rays and followed until they were moribund or to 800 days of age. We found that 1 GeV/nucleon (56)Fe ions do not appear to be substantially more effective than gamma rays for the induction of acute myeloid leukemia (AML). However, (56)Fe-ion-irradiated mice had a much higher incidence of hepatocellular carcinoma (HCC) than gamma-irradiated mice, with an estimated RBE of approximately 50. These data suggest a difference in the effects of HZE iron ions on the induction of leukemia compared to solid tumors, suggesting potentially different mechanisms of tumorigenesis.
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“Incidence of metastatic tumors significantly increased with Si and Fe particles compared to γ-rays or simulated solar protons.”
From A proposed change to astronaut exposures limits is a giant leap backwards for radiation protection (2021) · cites this paper as Weil et al., 2009
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“Hepatocellular carcinoma in male C3H/HeNCrl mice (Weil et al., 2009;Weil et al., 2014) Dose response for Si and Fe particles was qualitatively different from γ-rays.”
From A proposed change to astronaut exposures limits is a giant leap backwards for radiation protection (2021) · cites this paper as Weil et al., 2009
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Biological Experiments in Space: From Microgravity to Molecular Insights
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Metadata
- Authors
- Weil, M. M., Bedford, J. S., Bielefeldt-Ohmann, H., Ray, F. A., Genik, P. C., Ehrhart, E. J., Fallgren, C. M., Hailu, F., Battaglia, C. L. R., Charles, B., Callan, M. A., & Ullrich, R. L.
- Affiliations
- Colorado State University (US)
- Venue
- Radiation Research
- Publisher
- Radiation Research Society
- Published
- 2009-08
- Volume
- 172
- Issue
- 2
- Pages
- 213-219
- ISSN
- 0033-7587 (ISSN-L)
- 1938-5404
- OpenAlex
- W2157512479
- Cited by
- 115
- References
- 36
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 5 · 2021: 6 · 2020: 5 · 2019: 7 · 2018: 10 · 2017: 6 · 2016: 6 · 2015: 16 · 2014: 14 · 2013: 11 · 2012: 7
- FWCI
- 5.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Radiation Research (publishedVersion)
- PubMed (publishedVersion)
- BioOne Complete (BioOne) (submittedVersion)
- Funders
- U.S. Department of Energy
- National Aeronautics and Space Administration
- Topics
- Physical Sciences › Physics and Astronomy › Radiation › Radiation Therapy and Dosimetry
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Health Sciences › Medicine › Physiology (medical) › Spaceflight effects on biology
- Keywords
- acute myeloid leukemia, hepatocellular carcinoma, 56Fe ions, HZE radiation, space radiation, radiation-induced cancer, relative biological effectiveness, iron ion irradiation, CBA/CaJ mice, gamma radiation
- MeSH terms
- Animals, Cosmic Radiation, Dose-Response Relationship, Radiation, Carcinoma, Hepatocellular, Iron, Leukemia, Myeloid, Liver Neoplasms, Male, Neoplasms, Radiation-Induced, Radiation Dosage, Risk Factors, Whole-Body Irradiation, Incidence, Risk Assessment, Heavy Ions, Mice
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