PU.1 is a suppressor of myeloid leukemia, inactivated in mice by gene deletion and mutation of its DNA binding domain

Cook, Wendy D.; McCaw, Benjamin J.; Herring, Christopher; John, Deborah L.; Foote, Simon J.; Nutt, Stephen L.; Adams, Jerry M.

doi:10.1182/blood-2004-06-2234

PU.1 is a suppressor of myeloid leukemia, inactivated in mice by gene deletion and mutation of its DNA binding domain

In most myeloid leukemias induced in mice by γ-radiation, one copy of chromosome 2 has suffered a deletion. To search for a potential tumor suppressor gene in that region, we have delineated the deletions in a panel of these tumors. A commonly deleted region of 2 megabase pairs (Mbp) includes the…