Cited by 115Radiation Therapy and DosimetryEffects of Radiation ExposureSpaceflight effects on biology

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Incidence of Acute Myeloid Leukemia and Hepatocellular Carcinoma in Mice Irradiated with 1 GeV/nucleon56Fe Ions

Weil, Michael M., Bedford, Joel S., Bielefeldt-Ohmann, Helle, Ray, F. Andrew, Genik, Paula C., Ehrhart, Eugene J., Fallgren, Christina M., Hailu, Fitsum, Battaglia, Christine L. R., Charles, Brad, Callan, Matthew A., Ullrich, Robert L.·2009·Radiation Research

DOI 10.1667/rr1648.1

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Abstract

Estimates of cancer risks posed to space-flight crews by exposure to high atomic number, high-energy (HZE) ions are subject to considerable uncertainty because epidemiological data do not exist for human populations exposed to similar radiation qualities. We assessed the leukemogenic efficacy of one such HZE species, 1 GeV (56)Fe ions, a component of space radiation, in a mouse model for radiation-induced acute myeloid leukemia. CBA/CaJ mice were irradiated with 1 GeV/nucleon (56)Fe ions or (137)Cs gamma rays and followed until they were moribund or to 800 days of age. We found that 1 GeV/nucleon (56)Fe ions do not appear to be substantially more effective than gamma rays for the induction of acute myeloid leukemia (AML). However, (56)Fe-ion-irradiated mice had a much higher incidence of hepatocellular carcinoma (HCC) than gamma-irradiated mice, with an estimated RBE of approximately 50. These data suggest a difference in the effects of HZE iron ions on the induction of leukemia compared to solid tumors, suggesting potentially different mechanisms of tumorigenesis.

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Authors: Weil, M. M., Bedford, J. S., Bielefeldt-Ohmann, H., Ray, F. A., Genik, P. C., Ehrhart, E. J., Fallgren, C. M., Hailu, F., Battaglia, C. L. R., Charles, B., Callan, M. A., & Ullrich, R. L.
Affiliations: Colorado State University (US)
ORCID: Weil, Michael M.
Ray, F. Andrew
Genik, Paula C.
Venue: Radiation Research
Publisher: Radiation Research Society
Published: 2009-08
Volume: 172
Issue: 2
Pages: 213-219
ISSN: 0033-7587 (ISSN-L)
1938-5404
DOI: 10.1667/rr1648.1
OpenAlex: W2157512479
Cited by: 115
References: 36
Citations by year: 2026: 3 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 5 · 2021: 6 · 2020: 5 · 2019: 7 · 2018: 10 · 2017: 6 · 2016: 6 · 2015: 16 · 2014: 14 · 2013: 11 · 2012: 7
FWCI: 5.05
Type: journal article
Language: en
Open access: closed
Locations: Radiation Research (publishedVersion)
PubMed (publishedVersion)
BioOne Complete (BioOne) (submittedVersion)
Funders: U.S. Department of Energy
National Aeronautics and Space Administration
Topics: Physical Sciences › Physics and Astronomy › Radiation › Radiation Therapy and Dosimetry
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
Health Sciences › Medicine › Physiology (medical) › Spaceflight effects on biology
Keywords: acute myeloid leukemia, hepatocellular carcinoma, 56Fe ions, HZE radiation, space radiation, radiation-induced cancer, relative biological effectiveness, iron ion irradiation, CBA/CaJ mice, gamma radiation
MeSH terms: Animals, Cosmic Radiation, Dose-Response Relationship, Radiation, Carcinoma, Hepatocellular, Iron, Leukemia, Myeloid, Liver Neoplasms, Male, Neoplasms, Radiation-Induced, Radiation Dosage, Risk Factors, Whole-Body Irradiation, Incidence, Risk Assessment, Heavy Ions, Mice

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Incidence of Acute Myeloid Leukemia and Hepatocellular Carcinoma in Mice Irradiated with 1 GeV/nucleon56Fe Ions

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