The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
The role of let-7 in cell differentiation and cancer
Open accessAbstract
MicroRNAs (miRNAs or miRs) are small noncoding RNAs capable of regulating gene expression at the translational level. Current evidence suggests that a significant portion of the human genome is regulated by microRNAs, and many reports have demonstrated that microRNA expression is deregulated in human cancer. The let-7 family of microRNAs, first discovered in Caenorhabditis elegans, is functionally conserved from worms to humans. The human let-7 family contains 13 members located on nine different chromosomes, and many human cancers have deregulated let-7 expression. A growing body of evidence suggests that restoration of let-7 expression may be a useful therapeutic option in cancers, where its expression has been lost. In this review, we discuss the role of let-7 in normal development and differentiation, and provide an overview of the relationship between deregulated let-7 expression and tumorigenesis. The regulation of let-7 expression, cancer-relevant let-7 targets, and the relationship between let-7 and drug sensitivity are highlighted.
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Cited by
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Metadata
- Authors
- Boyerinas, B., Park, S.-M., Hau, A., Murmann, A. E., & Peter, M. E.
- Venue
- Endocrine-Related Cancer
- Publisher
- Bioscientifica
- Published
- 2010-03
- Volume
- 17
- Issue
- 1
- Pages
- F19-F36
- ISSN
- 1351-0088 (ISSN-L)
- 1479-6821
- OpenAlex
- W2142489285
- Cited by
- 669
- References
- 9
- FWCI
- 11.17
- Type
- journal article
- Language
- en
- Open access
- bronze
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