Congenital vasopressin deficiency and acute and chronic opiate effects on hypothalamo-pituitary-adrenal axis activity in Brattleboro rats
Open accessAbstract
A growing body of evidence suggests that vasopressinergic activity in the hypothalamus is important in stress-related behaviors (like drug abuse) in line with a role in the regulation of the hypothalamo-pituitary–adrenal axis (HPA). We hypothesized that in the naturally vasopressin-deficient Brattleboro rat, acute and chronic morphine treatment may lead to reduced HPA axis activity. Rats were treated either with a single dose of morphine (10 mg/kg subcutaneously) and serial blood samples were taken or were treated twice daily with increasing doses of morphine (10–100 mg/kg subcutaneously) for 16 days and animals were killed by decapitation 4 or 16 h after the last injection. Single morphine injection induced a biphasic ACTH and corticosterone elevation with smaller increases in vasopressin-deficient rats. Chronic morphine treatment induced the typical somatic and HPA axis changes of chronic stress; the absence of vasopressin did not prevent these changes. In rats repeatedly treated with morphine plasma, ACTH and corticosterone levels were elevated both 4 and 16 h after the last injection (short and long withdrawal) and the absence of vasopressin attenuated this response. Our data suggest that vasopressin plays a prominent role in morphine treatment and withdrawal-induced acute hormonal changes, but does not affect development of chronic hyperactivity of the HPA axis.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
Lindemann, L., Jaeschke, G., Michalon, A., Vieira, E., Honer, M., Spooren, W., Porter, R., Hartung, T., Kolczewski, S., Büttelmann, B., et al. (1909) · JAMA · doi:10.1001/jama.1909.02550020033007 · Cited by 7,865 · see citing works
Simmons, D. M., Arriza, J. L., & Swanson, L. W. (1989) · Journal of Histotechnology · doi:10.1179/his.1989.12.3.169 · Cited by 920 · see citing works
Vasopressinergic control of pituitary adrenocorticotropin secretion comes of age
Antoni, F. A. (1993) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1993.1004 · Cited by 636 · see citing works
Interchangeability of Stress and Amphetamine in Sensitization
Antelman, S. M., Eichler, A. J., Black, C. A., & Kocan, D. J. (1980) · Science · doi:10.1126/science.7188649 · Cited by 562 · see citing works
Regulation of pituitary ACTH secretion during chronic stress
Aguilera, G. (1994) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1994.1013 · Cited by 557 · cited 4× · see citing works
“Consistent with the assumption that CRH mRNA in the PVN is often elevated in chronic stress (Aguilera 1994), we detected increased levels in morphine-dependent control (di/C) rats 16 h after the last injection.”
BackgroundInfluentialTribollet, E., Barberis, C., Jard, S., Dubois-Dauphin, M., & Dreifuss, J. J. (1988) · Brain Research · doi:10.1016/0006-8993(88)91437-0 · Cited by 442 · see citing works
Single base deletion in the vasopressin gene is the cause of diabetes insipidus in Brattleboro rats
Schmale, H., & Richter, D. (1984) · Nature · doi:10.1038/308705a0 · Cited by 397 · see citing works
Role of different brain structures in the expression of the physical morphine withdrawal syndrome.
Maldonado, R. J., Stinus, L., Gold, L. H., & Koob, G. F. (1992) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)11090-2 · Cited by 390 · see citing works
Dallman, M. F. (1993) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(05)80017-7 · Cited by 329 · see citing works
Lightman, S. L., & Young, W. S. (1988) · The Journal of Physiology · doi:10.1113/jphysiol.1988.sp017261 · Cited by 215 · see citing works
Deroche‐Gamonet, V., Piazza, P. V., Casolini, P., Maccari, S., Moal, M. L., & Simon, H. (1992) · Brain Research · doi:10.1016/0006-8993(92)90205-n · Cited by 207 · see citing works
Buckingham, J. C., & Cooper, T. A. (2008) · Neuroendocrinology · doi:10.1159/000123927 · Cited by 173 · see citing works
Buckingham, J. C. (2008) · Neuroendocrinology · doi:10.1159/000123364 · Cited by 160 · see citing works
McNally, G. P., & Akil, H. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00105-7 · Cited by 141 · see citing works
Briggs, F. N., & Munson, P. L. (1955) · Endocrinology · doi:10.1210/endo-57-2-205 · Cited by 121 · see citing works
Role of hypothalamic inputs in maintaining pituitary-adrenal responsiveness in repeated restraint
Zelena, D., Mergl, Z., Földes, A., Kovács, K., Tóth, Z., & Makara, G. B. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00219.2003 · Cited by 121 · see citing works
Self-citationBreese, G. R., Knapp, D. J., & Overstreet, D. H. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300282 · Cited by 115 · see citing works
Ignar, D. M., & Kuhn, C. M. (1990) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)23071-3 · Cited by 102 · see citing works
Houshyar, H., Galigniana, M. D., Pratt, W. B., & Woods, J. H. (2001) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2001.00714.x · Cited by 93 · see citing works
Bohus, B., & de Wied, D. (1999) · Progress in brain research · doi:10.1016/s0079-6123(08)61593-9 · Cited by 91 · see citing works
Zhou, Y., Leri, F., Cummins, E., Hoeschele, M., & Kreek, M. J. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301419 · Cited by 89 · see citing works
Intermittent Morphine Administration Induces Dependence and is a Chronic Stressor in Rats
Houshyar, H., Gómez-Oliver, F., Manalo, S. L., Bhargava, A., & Dallman, M. F. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300271 · Cited by 87 · see citing works
Barna, I., Bálint, E., Baranyi, J., Bakos, N., Makara, G. B., & Haller, J. (2003) · Brain Research Bulletin · doi:10.1016/s0361-9230(03)00216-8 · Cited by 76 · see citing works
Self-citationBuckingham, J. C., & Cooper, T. A. (2008) · Neuroendocrinology · doi:10.1159/000124618 · Cited by 75 · see citing works
Schlosser, S. F., Almeida, O. F., Patchev, V. K., Yassouridis, A., & Elands, J. (1994) · Endocrinology · doi:10.1210/endo.135.5.7956927 · Cited by 75 · see citing works
Houshyar, H., Cooper, Z. D., & Woods, J. H. (2001) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2001.00713.x · Cited by 62 · see citing works
Endomorphins and activation of the hypothalamo-pituitary-adrenal axis
Coventry, T. L., Jessop, D. S., Finn, D. P., Crabb, M., Kinoshita, H., & Harbuz, M. (2001) · Journal of Endocrinology · doi:10.1677/joe.0.1690185 · Cited by 55 · see citing works
Effects of Naloxone on Hypothalamo-Pituitary-Adrenocortical Activity in the Rat
Buckingham, J. C., & Cooper, T. A. (2008) · Neuroendocrinology · doi:10.1159/000124481 · Cited by 42 · see citing works
α2-Adrenoreceptor subtypes regulate ACTH and β-endorphin secretions during stress in the rat
Zelena, D., Kiem, D. T., Barna, I., & Makara, G. B. (1999) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(98)00081-x · Cited by 36 · see citing works
Self-citationZelena, D., Filaretova, L. P., Mergl, Z., Barna, I., Tóth, Z., & Makara, G. B. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00118.2005 · Cited by 36 · see citing works
Self-citationDaly, E. S. E. (1996) · Life Sciences · doi:10.1016/s0024-3205(96)00535-8 · Cited by 35 · see citing works
Zelena, D., Barna, I., Mlynarik, M., Gupta, O. P., Ježová, D., & Makara, G. B. (2005) · Neuroendocrinology · doi:10.1159/000087034 · Cited by 33 · see citing works
Self-citationMaternal Genotype Influences Stress Reactivity of Vasopressin‐Deficient Brattleboro Rats
Zelena, D., Mergl, Z., & Makara, G. B. (2003) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2003.01101.x · Cited by 26 · see citing works
Self-citationVasoressin gene expression is attenuated in the fetal Brattleboro rat
Tol, H. H. M. V., Voorhuis, T. A. M., Snijdewint, F. G. M., Boer, G. J., & Burbach, J. P. H. (1986) · FEBS Letters · doi:10.1016/0014-5793(86)81394-1 · Cited by 17 · see citing works
Höllt, V., & Haarmann, I. (1985) · Neuropeptides · doi:10.1016/0143-4179(85)90059-9 · Cited by 10 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Vasopressin V1a and V1b Receptors: From Molecules to Physiological Systems
Koshimizu, T., Nakamura, K., Egashira, N., Hiroyama, M., Nonoguchi, H., & Tanoue, A. (2012) · Physiological Reviews · doi:10.1152/physrev.00035.2011 · Cited by 413 · see citing works
Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development
Koob, G. F. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000083 · Cited by 337 · see citing works
The vasopressin Avpr1b receptor: Molecular and pharmacological studies
Roper, J. A., O'Carroll, A.-M., Young, W. S., & Lolait, S. (2010) · Stress · doi:10.3109/10253890.2010.512376 · Cited by 116 · see citing works
Goncharova, N. D. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00026 · Cited by 99 · see citing works
Zelena, D., Domokos, Á., Jain, S. K., Jankord, R., & Filaretova, L. P. (2009) · Journal of Endocrinology · doi:10.1677/joe-09-0096 · Cited by 56 · see citing works
Self-citationSouthey, B. R., Lee, J. E., Zamdborg, L., Atkins, N., Mitchell, J. W., Li, M., Gillette, M. U., Kelleher, N. L., & Sweedler, J. V. (2013) · Analytical Chemistry · doi:10.1021/ac4023378 · Cited by 45 · see citing works
Endogenous opiates and behavior: 2008
Bodnar, R. J. (2009) · Peptides · doi:10.1016/j.peptides.2009.09.027 · Cited by 39 · see citing works
Changes in adaptability following perinatal morphine exposure in juvenile and adult rats
Klausz, B., Pintér, O., Sobor, M., Gyarmati, Z., Fürst, Z., Tímár, J., & Zelena, D. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.11.025 · Cited by 38 · see citing works
Self-citationRoper, J. A., Craighead, M. W., O'Carroll, A.-M., & Lolait, S. J. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02070.x · Cited by 28 · see citing works
Zelena, D., Pintér, O., Balázsfi, D., Langnaese, K., Richter, K., Landgraf, R., Makara, G. B., & Engelmann, M. (2015) · Amino Acids · doi:10.1007/s00726-015-2026-x · Cited by 23 · see citing works
Self-citationHonda, K., & Takano, Y. (2009) · Journal of Pharmacological Sciences · doi:10.1254/jphs.08r30fm · Cited by 23 · see citing works
Makara, G. B., Varga, J. M., Barna, I., Pintér, O., Klausz, B., & Zelena, D. (2012) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-012-9842-2 · Cited by 20 · see citing works
Self-citationVarga, J. M., Domokos, Á., Barna, I., Jankord, R., Bagdy, G., & Zelena, D. (2010) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2010.09.014 · Cited by 20 · see citing works
Self-citationZelena, D., Mergl, Z., & Makara, G. B. (2008) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2008.11.003 · Cited by 17 · see citing works
Self-citationOpium Effect in Pregnancy on the Dynamics of Maternal Behavior: Testing a Neurochemical Model
Rezaei, S., Bakhshani, N., Fanaei, H., & Trofimova, I. N. (2021) · Neuropsychobiology · doi:10.1159/000512698 · Cited by 12 · see citing works
Blunted HPA axis response in lactating, vasopressin-deficient Brattleboro rats
Fodor, A., Pintér, O., Domokos, Á., Langnaese, K., Barna, I., Engelmann, M., & Zelena, D. (2013) · Journal of Endocrinology · doi:10.1530/joe-13-0224 · Cited by 12 · see citing works
Self-citationCastro, N. C. F., Silva, I. S., Cartágenes, S. D. C., Fernandes, L. M. P., Ribera, P. C., Barros, M. A., Prediger, R. D., Fontes-Júnior, E. A., & Maia, C. D. S. F. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics14010029 · Cited by 7 · see citing works
Koob, G. F., Arends, M. A., McCracken, M. L., & Moal, M. L. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-816988-9.00001-1 · Cited by 2 · see citing works
Brain Regeneration - in vitro and in vivo studies of exercise-related effects on brain plasticity
Bull, C. (2008) · Gothenburg University Publications Electronic Archive (Gothenburg University)
- Authors
- Domokos, Á., Mergl, Z., Barna, I., Makara, G. B., & Zelena, D.
- Affiliations
- HUN-REN Institute of Experimental Medicine (HU)
- ORCID
- Zelena, Dóra
- Venue
- Journal of Endocrinology
- Publisher
- Bioscientifica
- Published
- 2007-10-16
- Volume
- 196
- Issue
- 1
- Pages
- 113-121
- ISSN
- 0022-0795 (ISSN-L)
- 1479-6805
- OpenAlex
- W2104838175
- Cited by
- 19
- References
- 35
- Citations by year
- 2023: 1 · 2021: 2 · 2020: 1 · 2015: 1 · 2013: 3 · 2012: 2
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- public-domain
- Locations
- Journal of Endocrinology (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Funders
- Hungarian Scientific Research Fund (T 043161)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- vasopressin deficiency, Brattleboro rats, morphine, opioid withdrawal, hypothalamic-pituitary-adrenal axis, ACTH, corticosterone, chronic stress, stress response, drug abuse
- MeSH terms
- Adrenal Glands, Adrenocorticotropic Hormone, Animals, Arginine Vasopressin, Corticosterone, Corticotropin-Releasing Hormone, Hypothalamus, Male, Morphine, Mutation, Pituitary Gland, Pro-Opiomelanocortin, Rats, Brattleboro, RNA, Messenger, In Situ Hybridization, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review