Oxytocin-stimulated release of adrenocorticotropin from the rat pituitary is mediated by arginine vasopressin receptors of the V1b type
Abstract
Previous work showed the existence of receptors for arginine vasopressin (AVP) in the anterior pituitary; these receptors were classified as belonging to a distinct AVP receptor subtype, referred to as AVP-V1b receptors, and are thought to mediate the well documented ACTH-releasing activity of AVP. In the present work, high affinity receptors for another neurohypophyseal hormone, oxytocin (OT), were also shown to be present within the rat anterior pituitary; to this end, [125I]d(CH2)5[Tyr(Me)2Thr4Tyr-NH2(9)]OVT was used as a ligand in receptor binding studies. Experiments on dispersed rat anterior pituitary cells in a superfusion system confirmed earlier reports that OT acts as an additional secretagogue of ACTH, with significant effects first seen at concentrations as low as 1 nM. Further studies addressed the question of whether stimulation of ACTH release is mediated by OT receptors or whether receptors for AVP (V1b receptors) might serve this role. For this, highly selective agonist and antagonist ligands of the OT receptor and nonselective agonist and antagonist ligands of the V1b receptor were employed. Neither the OT receptor agonist Thr4Gly7OT nor the OT receptor antagonist des-Gly(NH2)9d(CH2)5-[Tyr(Me)2 Thr4]OVT displayed any influence on basal ACTH release, and des-Gly(NH2)9d(CH2)5-[Tyr(Me)2Thr4]OVT did not interfere with OT-induced ACTH release; these results indicated that OT promotes ACTH release through a receptor(s) other than the OT receptor itself. Evidence for the involvement of AVP V1b receptors was provided by the observation that the AVP receptor antagonist dP[Tyr(Me2)]AVP completely abolished OT-elicited increases in ACTH release. Thus, AVP V1b receptors mediate the actions of two structurally related peptides on ACTH secretion; the role of OT receptors in adenohypophyseal function remains to be determined.
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OT neurons in the PVN can regulate the HPA axis since PVN OT is released into the hypothalamo-hypophyseal portal vasculature, enhancing CRH-mediated ACTH release via binding the V1b vasopressin receptor.
“OT neurons in the PVN can also regulate the HPA axis since PVN OT is released into the hypothalamo-hypophyseal portal vasculature, enhancing the CRH-mediated release of ACTH via binding the V1b type vasopressin receptor (Schlosser, Almeida, Patchev, Yassouridis, & Elands, 1994).”
From Hypothalamic–pituitary–adrenal and hypothalamic–pituitary–gonadal axes: sex differences in regulation of stress responsivity (2017) · cites this paper as Schlosser, Almeida, Patchev, Yassouridis, & Elands, 1994
In the pituitary gland, OT induces release of adrenocorticotropin via both OTRs and V1bRs in male mice and female rats.
“In the pituitary gland OT induces release of adrenocorticotropin via both OTRs and V1bRs in male mice and female rats [50; 51].”
From Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery (2018) · cites this paper as [50]
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- Authors
- Schlosser, S. F., Almeida, O. F., Patchev, V. K., Yassouridis, A., & Elands, J.
- Affiliations
- Max Planck Institute of Psychiatry (DE)
- Max Planck Society (DE)
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1994-11
- Volume
- 135
- Issue
- 5
- Pages
- 2058-2063
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2038222018
- Cited by
- 75
- References
- 13
- Citations by year
- 2023: 2 · 2022: 1 · 2021: 1 · 2019: 3 · 2018: 3 · 2017: 6 · 2015: 3 · 2014: 3 · 2013: 6 · 2012: 4
- FWCI
- 3.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- oxytocin, vasopressin, V1b receptor, ACTH, ACTH secretion, anterior pituitary, oxytocin receptor, receptor binding, neurohypophyseal hormones
- MeSH terms
- Adrenocorticotropic Hormone, Animals, Female, Oxytocin, Pituitary Gland, Anterior, Rats, Sprague-Dawley, Receptors, Vasopressin, Rats
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