The DOI matches its Crossref record; 242 of the 242 references it cites were found in a registry or an index.
Glucocorticoids and the circadian clock
Open accessAbstract
Glucocorticoids, hormones produced by the adrenal gland cortex, perform numerous functions in body homeostasis and the response of the organism to external stressors. One striking feature of their regulation is a diurnal release pattern, with peak levels linked to the start of the activity phase. This release is under control of the circadian clock, an endogenous biological timekeeper that acts to prepare the organism for daily changes in its environment. Circadian control of glucocorticoid production and secretion involves a central pacemaker in the hypothalamus, the suprachiasmatic nucleus, as well as a circadian clock in the adrenal gland itself. Central circadian regulation is mediated via the hypothalamic-pituitary-adrenal axis and the autonomic nervous system, while the adrenal gland clock appears to control sensitivity of the gland to the adrenocorticopic hormone (ACTH). The rhythmically released glucocorticoids in turn might contribute to synchronisation of the cell-autonomous clocks in the body and interact with them to time physiological dynamics in their target tissues around the day.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Evidence is rapidly accumulating to indicate that misalignment between central and peripheral clocks has a host of adverse effects, including an increased risk of obesity and type 2 diabetes (37, 39).”
From Adverse effects of two nights of sleep restriction on the hypothalamic-pituitary-adrenal axis in healthy men (2014) · cites this paper as [37]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Items 201–242 of 242
Ciocca, D., Maurel, D., & Bosler, O. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.2.e260 · Cited by 69
Torres‐Farfan, C., Serón‐Ferré, M., Dinet, V., & Korf, H. (2005) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2005.00279.x · Cited by 68
Search for the feeding-entrainable circadian oscillator: a complex proposition
Davidson, A. J. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00073.2006 · Cited by 64
Pulsatile ACTH secretion: Variation with time of day and relationship to cortisol
Carnes, M., Kalin, N. H., Lent, S. J., Barksdale, C. M., & Brownfield, M. S. (1988) · Peptides · doi:10.1016/0196-9781(88)90268-9 · Cited by 63 · cited 1×
“These rhythms are paralleled by similar rhythms in the adrenocorticotropic hormone (ACTH), albeit less robust and of lower amplitude (Carnes et al. 1988, 1989, Veldhuis et al. 1990, Sarnyai et al. 1995, Gudmundsson & Carnes 1997, Chrousos 1998).”
BackgroundGelder, R. N. V., Bae, H. H., Palazzolo, M., et al. (1995) · Current Biology · doi:10.1016/s0960-9822(95)00280-6 · Cited by 62
Ultradian endocrine rhythms are altered by a circadian mutation in the Syrian hamster
Loudon, A. S. I., Wayne, N. L., Krieg, R. J., Iranmanesh, A., Veldhuis, J. D., & Menaker, M. (1994) · Endocrinology · doi:10.1210/endo.135.2.8033819 · Cited by 62
Molecular genetics of the fruit-fly circadian clock
Rosato, E., Tauber, E., & Kyriacou, C. P. (2006) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201547 · Cited by 60
Klemcke, H. G., Nienaber, J. A., & Hahn, G. L. (1989) · Experimental Biology and Medicine · doi:10.3181/00379727-190-42828 · Cited by 59
Srivastava, A. K., & MEIER, A. H. (1972) · Science · doi:10.1126/science.177.4044.185 · Cited by 56
Robinson, C., Shore, R. F., Bonass, W. A., et al. (1998) · Caries Research · doi:10.1159/000016452 · Cited by 54
Winding up the cyanobacterial circadian clock
Mackey, S. R., & Golden, S. S. (2007) · Trends in Microbiology · doi:10.1016/j.tim.2007.08.005 · Cited by 50
Daily Rhythms in Cortisol and Melatonin in Primate Cerebrospinal Fluid
Perlow, M. J., Reppert, S. M., BOYAR, R. M., & Klein, D. C. (2008) · Neuroendocrinology · doi:10.1159/000123157 · Cited by 50
Amir, S., & Robinson, B. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.08.057 · Cited by 48
Circadian rhythms in adrenal organ cultures.
Rv, A. (1971) · PubMed · Cited by 48
Ciocca, D., Maurel, D., & Bosler, O. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00287.2001 · Cited by 47
Kennaway, D. J., Owens, J. A., Voultsios, A., & Varcoe, T. J. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00223.2006 · Cited by 46
Paterson, J. M., Holmes, M. C., Kenyon, C. J., Carter, R., Mullins, J. J., & Seckl, J. R. (2006) · Endocrinology · doi:10.1210/en.2006-0603 · Cited by 46
Pulsatile adrenocorticotropic hormone: An overview
Guðmundsson, A., & Carnes, M. L. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00005-4 · Cited by 44
Circadian control of cell division in unicellular organisms
Mori, T., & Johnson, C. H. (2000) · Springer eBooks · doi:10.1007/978-1-4615-4253-7_16 · Cited by 42
The daily rhythm of the secretion of corticotrophin and corticosterone in rats and mice.
Pn, C. (1971) · PubMed · Cited by 41
Rhythmic changes in rate of the mammalian heart and heart cells during prolonged isolation
Tharp, G. D., & Folk, G. E. (1965) · Comparative Biochemistry and Physiology · doi:10.1016/0010-406x(65)90202-1 · Cited by 41
Ultradian glucocorticoid rhythms in monkeys and rats continue during stress
Tapp, W. N., Holaday, J. W., & Natelson, B. H. (1984) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1984.247.5.r866 · Cited by 38
11β-HSD1, Inflammation, Metabolic Disease and Age-related Cognitive (dys)Function
Chapman, K. E., & Seckl, J. R. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9504-9 · Cited by 37
"What watch? ... such much!"* Complexity and evolution of circadian clocks
Roenneberg, T., & Merrow, M. W. (2002) · Cell and Tissue Research · doi:10.1007/s00441-002-0568-1 · Cited by 37
Sarnyai, Z., Veldhuis, P. P., Mello, N. K., Mendelson, J. H., Erös-Sarnyai, M., Mercer, G., Gelles, H., & Kelly, M. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.1.7829639 · Cited by 36
Region‐specific regulation of glucocorticoid receptor/HSP90 expression and interaction in brain
Furay, A. R., Murphy, E., Mattson, M. P., Guo, Z., & Herman, J. P. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03953.x · Cited by 31
Neuromedin‐U is regulated by the circadian clock in the SCN of the mouse
Graham, E. S., Littlewood, P. A., Turnbull, Y. D., Mercer, J. G., Morgan, P. J., & Barrett, P. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03923.x · Cited by 30
PROMOTER ANALYSIS OF MAMMALIAN CLOCK CONTROLLED GENES
Bożek, K., Kiełbasa, S. M., Kramer, A., et al. (2007) · doi:10.1142/9781860949920_0007 · Cited by 29
Food Entrainment: Methodological Issues
Landry, G. J., & Mistlberger, R. E. (2007) · Journal of Biological Rhythms · doi:10.1177/0748730407307811 · Cited by 28
Burén, J., Bergström, S., Loh, E., Söderström, I., Olsson, T., & Mattsson, C. (2007) · Endocrinology · doi:10.1210/en.2006-0897 · Cited by 26
Sleep medicine education: are medical schools and residency programs napping on the job?
Gamaldo, C. E., & Salas, R. M. E. (2008) · Nature Clinical Practice Neurology · doi:10.1038/ncpneuro0808 · Cited by 22
SCN-Independent circadian oscillators in the rat
Hiroshige, T., Honma, K., & Honma, S. (1991) · Brain Research Bulletin · doi:10.1016/0361-9230(91)90139-b · Cited by 22
Rat Adrenal Transplants are Reinnervated: An Invalid Model of Denervated Adrenal Cortical Tissue
Ulrich‐Lai, Y. M., & Engeland, W. C. (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00534.x · Cited by 20
Gooley, J. J., & Saper, C. B. (2007) · Journal of Biological Rhythms · doi:10.1177/0748730407307810 · Cited by 20
Corticosterone and Activity: The Long Arms of the Clock Talk Back
Buijs, R. M., & Escobar, C. (2007) · Endocrinology · doi:10.1210/en.2007-0926 · Cited by 20
Systems Biology of Circadian Rhythms: An Outlook
Haro, L. D., & Panda, S. (2006) · Journal of Biological Rhythms · doi:10.1177/0748730406294767 · Cited by 20
Chrousos, G. P. (1998) · Endocrinology · doi:10.1210/en.139.2.437 · Cited by 20
Herzog, E. D., & Muglia, L. J. (2006) · Nature Neuroscience · doi:10.1038/nn0306-300 · Cited by 18
Lego clocks: building a clock from partsPreprint
Brunner, M., Simons, M. J. P., & Merrow, M. W. (2008) · Genes & Development · doi:10.1101/gad.1686608 · Cited by 13
Circadian Rhythms: Per2bations in the Liver Clock
Reddy, A. B., & Maywood, E. S. (2007) · Current Biology · doi:10.1016/j.cub.2007.02.031 · Cited by 8
29th Annual Meeting of the Nordic Microcirculation Society
Risberg, B. (1999) · Journal of Vascular Research · doi:10.1159/000025681 · Cited by 2
Flagged first, then by citations
Research works printed but not linked: 23
- Andrews, 1971, Gegenbaurs Morphologisches Jahrbuch, 117, 89
- Andrews, 1964, Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology, 11, 393
- 1988, 1, 887
- 2007, GENOME INFORMATICS, 18, 65
- 1993, American Journal of Physiology -- Legacy Content, 264, R1186
- 1971, Journal of Endocrinology, 49, xi
- 2001, 32, 657
- 1978, American Journal of Physiology -- Legacy Content, 235, R210
- 2006, 50, 465
- Dijkstra, 1996, Endocrinology, 137, 540, 10.1210/en.137.2.540 · DOI
- 1991, American Journal of Physiology -- Legacy Content, 261, R1257
- Loudon, 1994, Endocrinology, 135, 712, 10.1210/en.135.2.712 · DOI
- 1999, 92, 267
- Sarnyai, 1995, Journal of Clinical Endocrinology & Metabolism, 80, 54, 10.1210/jc.80.1.54 · DOI
- 2006, 140, 753
- Stephan, 2002, Journal of Biological Rhythms, 17, 284, 10.1177/074873040201700402 · DOI · Paper page
- 1981, 6, 2625
- 1984, American Journal of Physiology -- Legacy Content, 247, R866
- Tharp, 1965, Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology, 14, 255
- Torra, 2000, Endocrinology, 141, 3799, 10.1210/en.141.10.3799 · DOI
- 1995, 14, 697
- Windle, 1998, Endocrinology, 139, 4044, 10.1210/en.139.10.4044 · DOI · Paper page
- 1992, Journal of Cell Science, 16, 123
Cited by
Sorted by citations
Circadian control of the immune system
Scheiermann, C., Kunisaki, Y., & Frenette, P. S. (2013) · Nature Reviews Immunology · doi:10.1038/nri3386 · Cited by 1,135
The cortisol awakening response: More than a measure of HPA axis function
Clow, A., Hucklebridge, F., Stalder, T., Evans, P., & Thorn, L. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.12.011 · Cited by 635
The Functional and Clinical Significance of the 24-Hour Rhythm of Circulating Glucocorticoids
Oster, H., Challet, E., Ott, V., Arvat, E., de Kloet, E. R., Dijk, D.-J., Lightman, S., Vgontzas, A., & Van Cauter, E. (2017) · Endocrine Reviews · doi:10.1210/er.2015-1080 · Cited by 548
Gong, S., Miao, Y.-L., Jiao, G.-Z., Sun, M.-J., Li, H., Lin, J., Luo, M.-J., & Tan, J.-H. (2015) · PLOS ONE · doi:10.1371/journal.pone.0117503 · Cited by 460
Agorastos, A., Pervanidou, P., Chrousos, G. P., & Baker, D. G. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00118 · Cited by 385
“Circadian acetylation and deacetylation of the GR, modulated by melatonin, allows for these changes in tissue sensitivity (308, 312, 315, 316).”
Background
Metadata
- Authors
- Dickmeis, T.
- Corresponding author
- Dickmeis, Thomas
- ORCID
- Dickmeis, Thomas
- Venue
- Journal of Endocrinology
- Publisher
- Bioscientifica
- Published
- 2008-10-29
- Volume
- 200
- Issue
- 1
- Pages
- 3-22
- ISSN
- 0022-0795 (ISSN-L)
- 1479-6805
- OpenAlex
- W2092647381
- Cited by
- 494
- References
- 242
- Citations by year
- 2026: 18 · 2025: 15 · 2024: 32 · 2023: 24 · 2022: 24 · 2021: 33 · 2020: 37 · 2019: 33 · 2018: 24 · 2017: 26 · 2016: 33 · 2015: 24 · 2014: 37 · 2013: 45 · 2012: 31
- FWCI
- 2.13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- glucocorticoids, circadian clock, suprachiasmatic nucleus, hypothalamic-pituitary-adrenal axis, ACTH sensitivity, cell-autonomous clock, adrenal cortex, circadian rhythm
- MeSH terms
- Adrenal Glands, Animals, Biological Clocks, Circadian Rhythm, Gene Expression Regulation, Glucocorticoids, Humans, Hypothalamus, Neurosecretory Systems
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
