The “other” circadian system: food as a Zeitgeber

Stephan, F.K.

doi:10.1177/074873002129002591

Cited by 672Circadian rhythm and melatoninSleep and Work-Related FatigueRegulation of Appetite and Obesity

The “other” circadian system: food as a Zeitgeber

Stephan, F.K.·2002·Journal of Biological Rhythms

DOI 10.1177/074873002129002591

Open this paper in CoChat — free account

Abstract

It is not surprising that limiting food access to a particular time of day has profound effects on the behavior and physiology of animals. It has been clear for some time that pre-meal behavioral activation, a rise in core temperature, elevated serum corticosterone, and an increase in duodenal disaccharidases are under circadian control and that the observed circadian properties are not abolished by lesions of the suprachiasmatic nucleus (SCN), but the search for the locus of a separate food-entrainable oscillator (FEO) has not been successful. The cloning of circadian clock genes and the discovery that these genes are expressed in many central nervous system structures outside the SCN and in peripheral tissues have led to new strategies for investigating potential loci of an FEO. Recent findings concerning the entrainment of clock gene expression in the central nervous system and in peripheral tissues by periodic food access are presented, and the implications of these findings for a better understanding of a circadian system that entrains to meals, rather than to light, are discussed.

Integrity signals

Registry

Crossref · 10.1177/074873002129002591

Cites

0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Food can regulate various peripheral body clocks and metabolic rhythms and is often referred to as a zeitgeber.
“Food is often referred to as a zeitgeber (14) because of its ability to regulate various peripheral body clocks and metabolic rhythms (2, 15, 16).”
From Chronotype: Implications for Epidemiologic Studies on Chrono-Nutrition and Cardiometabolic Health (2019) · cites this paper as [14]
Food intake and eating patterns exhibit diurnal rhythms.
“Food intake and eating patterns likewise exhibit diurnal rhythms (14, 17)”
From Chronotype: Implications for Epidemiologic Studies on Chrono-Nutrition and Cardiometabolic Health (2019) · cites this paper as [14]
Restriction of food availability to a short time window causes behavioral and physiologic changes, including food anticipatory activity.
“It has been known for many decades that restriction of food availability to a short time window will cause the manifestation of behavioral and physiologic changes, including food anticipatory activity.”
From Circadian rhythms, metabolism, and chrononutrition in rodents and humans (2016) · cites this paper as [75]
Animals shift their activity rhythms and sleep/wake cycle in response to restricted food availability at a certain time of day.
“Animals also shift their activity rhythms and sleep/wake cycle in response to restricted food availability at a certain time of day (Stephan, 2002).”
From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Stephan, 2002
Entrainment to food or other non-photic stimuli is controlled by SCN-independent pacemakers located in various regions of the brain and other organs.
“This entrainment to food, or other non-photic stimuli, is controlled by SCN-independent pacemakers located in various regions of the brain and other organs (Stokkan et al., 2001; Stephan, 2002; Mieda et al., 2006).”
From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Stephan, 2002

The publisher hasn’t deposited this paper’s reference list.

Sorted by citations

Hypothalamic regulation of sleep and circadian rhythms
Saper, C. B., Scammell, T. E., & Lu, J. (2005) · Nature · doi:10.1038/nature04284 · Cited by 2,804 · see citing works
The mammalian circadian timing system: organization and coordination of central and peripheral clocks
Dibner, C., Schibler, U., & Albrecht, U. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135821 · Cited by 2,421 · see citing works
Central and Peripheral Circadian Clocks in Mammals
Mohawk, J. A., Green, C. B., & Takahashi, J. S. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-153128 · Cited by 2,265 · see citing works
Impact of intermittent fasting on health and disease processes
Mattson, M. P., Longo, V. D., & Harvie, M. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.10.005 · Cited by 1,187 · see citing works
The Meter of Metabolism
Green, C. B., Takahashi, J. S., & Bass, J. (2008) · Cell · doi:10.1016/j.cell.2008.08.022 · Cited by 902 · see citing works
Circadian rhythms, sleep, and metabolism
Huang, W., Ramsey, K. M., Marcheva, B., & Bass, J. T. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46043 · Cited by 726 · see citing works
Circadian genes, rhythms and the biology of mood disorders
McClung, C. A. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.02.003 · Cited by 666 · see citing works
Hemolymph Sugar Homeostasis and Starvation-Induced Hyperactivity Affected by Genetic Manipulations of the Adipokinetic Hormone-Encoding Gene in Drosophila melanogaster
Lee, G., & Park, J. H. (2004) · Genetics · doi:10.1534/genetics.167.1.311 · Cited by 621 · see citing works
The aging clock: circadian rhythms and later life
Hood, S., & Amir, S. (2017) · Journal of Clinical Investigation · doi:10.1172/jci90328 · Cited by 621 · see citing works
The hypothalamic integrator for circadian rhythms
Saper, C. B., Lü, J., Chou, T. C., & Gooley, J. J. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2004.12.009 · Cited by 528 · see citing works
Metabolism and Circadian Rhythms—Implications for Obesity
Froy, O. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0014 · Cited by 505 · see citing works
Circadian Rhythms and Metabolic Syndrome
Maury, E., Ramsey, K. M., & Bass, J. T. (2010) · Circulation Research · doi:10.1161/circresaha.109.208355 · Cited by 502 · see citing works
Glucocorticoids and the circadian clock
Dickmeis, T. (2009) · Journal of Endocrinology · doi:10.1677/joe-08-0415 · Cited by 494 · see citing works
The genus Laminaria sensu lato : recent insights and developments
Bartsch, I., Wiencke, C., Bischof, K., Buchholz, C., Buck, B. H., Eggert, A., Feuerpfeil, P., Hanelt, D., Jacobsen, S., Karez, R., et al. (2008) · European Journal of Phycology · doi:10.1080/09670260701711376 · Cited by 469 · see citing works
Melatonin, the circadian multioscillator system and health: the need for detailed analyses of peripheral melatonin signaling
Hardeland, R., Madrid, J. A., Tan, D. X., & Reiter, R. J. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00934.x · Cited by 449 · see citing works
Altered patterns of sleep and behavioral adaptability in NPAS2-deficient mice
Dudley, C. A., Erbel-Sieler, C., Estill, S. J., Reick, M., Franken, P., Pitts, S., & McKnight, S. L. (2003) · Science · doi:10.1126/science.1082795 · Cited by 415 · see citing works
Homeostatic, circadian, and emotional regulation of sleep
Saper, C. B., Cano, G., & Scammell, T. E. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20770 · Cited by 405 · see citing works
Social influences on mammalian circadian rhythms: animal and human studies
Mistlberger, R. E., & Skene, D. J. (2004) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1017/s1464793103006353 · Cited by 402 · see citing works
Circadian rhythms in the hypothalamo-pituitary-adrenal (HPA) axis
Kalsbeek, A., van der Spek, R., Lei, J., Endert, E., Buijs, R. M., & Fliers, E. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.06.042 · Cited by 380 · see citing works
CIRCADIAN CLOCK-ASSOCIATED 1 regulates ROS homeostasis and oxidative stress responses
Lai, A. G., Doherty, C. J., Mueller‐Roeber, B., Kay, S. A., Schippers, J. H. M., & Dijkwel, P. P. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209148109 · Cited by 371 · see citing works
Systems approach identifies an organic nitrogen-responsive gene network that is regulated by the master clock control gene CCA1
Gutiérrez, R. A., Stokes, T. L., Thum, K. E., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800211105 · Cited by 367 · see citing works
Challenging the omnipotence of the suprachiasmatic timekeeper: are circadian oscillators present throughout the mammalian brain?
Guilding, C., & Piggins, H. D. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05581.x · Cited by 348 · see citing works
Neurobiology of food anticipatory circadian rhythms
Mistlberger, R. E. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.04.015 · Cited by 345 · see citing works
Stomach ghrelin-secreting cells as food-entrainable circadian clocks
LeSauter, J., Hoque, N., WEINTRAUB, M. I., Pfaff, D. W., & Silver, R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906426106 · Cited by 318 · see citing works
The use of a running wheel to measure activity in rodents: Relationship to energy balance, general activity, and reward
Novak, C. M., Burghardt, P. R., & Levine, J. A. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.12.012 · Cited by 308 · see citing works
Interoceptive dysfunction: Toward an integrated framework for understanding somatic and affective disturbance in depression
Harshaw, C. (2015) · Psychological Bulletin · doi:10.1037/a0038101 · Cited by 302 · see citing works
Neuronal Mechanisms for Sleep/Wake Regulation and Modulatory Drive
Eban-Rothschild, A., Appelbaum, L., & de Lecea, L. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.294 · Cited by 282 · see citing works
The dorsomedial hypothalamic nucleus as a putative food-entrainable circadian pacemaker
Mieda, M., Williams, S. C., Richardson, J. A., Tanaka, K., & Yanagisawa, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604189103 · Cited by 290 · see citing works
Scheduled exercise phase shifts the circadian clock in skeletal muscle
WOLFF, G., & ESSER, K. A. (2012) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318255cf4c · Cited by 291 · see citing works
The relationship between nutrition and circadian rhythms in mammals
Froy, O. (2007) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2007.03.001 · Cited by 286 · see citing works
Nonphotic Entrainment in Humans?
Mistlberger, R. E., & Skene, D. J. (2005) · Journal of Biological Rhythms · doi:10.1177/0748730405277982 · Cited by 267 · see citing works
Circadian rhythms, metabolism, and chrononutrition in rodents and humans
Johnston, J. D., Ordovás, J. M., Scheer, F. A., & Turek, F. W. (2016) · Advances in Nutrition · doi:10.3945/an.115.010777 · Cited by 258 · see citing works
Circadian clocks: setting time by food
Mendoza, J. (2007) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2006.01510.x · Cited by 257 · see citing works
Mice under Caloric Restriction Self-Impose a Temporal Restriction of Food Intake as Revealed by an Automated Feeder System
Acosta-Rodríguez, V. A., de Groot, M. H. M., Rijo‐Ferreira, F., Green, C. B., & Takahashi, J. S. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.06.007 · Cited by 252 · see citing works
Chronotype: Implications for Epidemiologic Studies on Chrono-Nutrition and Cardiometabolic Health
Almoosawi, S., Vingeliene, S., Gachon, F., Voortman, T., Palla, L., Johnston, J. D., Van Dam, R. M., Darimont, C., & Karagounis, L. G. (2019) · Advances in Nutrition · doi:10.1093/advances/nmy070 · Cited by 247 · see citing works
SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus
Satoh, A., Brace, C. S., Ben-Josef, G., West, T., Wozniak, D. F., Holtzman, D. M., Herzog, E. D., & Imai, S.-I. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1385-10.2010 · Cited by 237 · see citing works
A sense of time: how molecular clocks organize metabolism
Kohsaka, A., & Bass, J. T. (2006) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2006.11.005 · Cited by 233 · see citing works
The mammalian circadian system: a hierarchical multi-oscillator structure for generating circadian rhythm
Honma, S. (2018) · The Journal of Physiological Sciences · doi:10.1007/s12576-018-0597-5 · Cited by 233 · see citing works
A Blind Circadian Clock in Cavefish Reveals that Opsins Mediate Peripheral Clock Photoreception
Cavallari, N., Frigato, E., Vallone, D., Fröhlich, N., López‐Olmeda, J. F., Foà, A., Berti, R., Sánchez‐Vázquez, F. J., Bertolucci, C., & Foulkes, N. S. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1001142 · Cited by 231 · see citing works
Mammalian circadian clock and metabolism – the epigenetic link
Bellet, M. M., & Sassone‐Corsi, P. (2010) · Journal of Cell Science · doi:10.1242/jcs.051649 · Cited by 237 · see citing works
Clock is important for food and circadian regulation of macronutrient absorption in mice
Pan, X., & Hussain, M. M. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m900085-jlr200 · Cited by 226 · see citing works
Circadian rhythms disrupted by light at night and mistimed food intake alter hormonal rhythms and metabolism
Meléndez-Fernández, O. H., Liu, J. A., & Nelson, R. J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043392 · Cited by 227 · see citing works
Chrono‐nutrition: From molecular and neuronal mechanisms to human epidemiology and timed feeding patterns
Flanagan, A., Bechtold, D. A., Pot, G. K., & Johnston, J. D. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15246 · Cited by 245 · see citing works
Food-anticipatory circadian rhythms: concepts and methods
Mistlberger, R. E. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06965.x · Cited by 224 · see citing works
Food as a circadian time cue - evidence from human studies
Lewis, P., Oster, H., Korf, H. W., Foster, R. G., & Erren, T. C. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0318-z · Cited by 207 · see citing works
Circadian dysfunction in disease
Bechtold, D. A., Gibbs, J. E., & Loudon, A. S. I. (2010) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2010.01.002 · Cited by 206 · see citing works
The midpoint of sleep is associated with dietary intake and dietary behavior among young Japanese women
Sato-Mito, N., Sasaki, S., Murakami, K., Okubo, H., Takahashi, Y., Shibata, S., Yamada, K., & Sato, K. (2011) · Sleep Medicine · doi:10.1016/j.sleep.2010.09.012 · Cited by 191 · see citing works
Gut microbiota as a transducer of dietary cues to regulate host circadian rhythms and metabolism
Choi, H., Rao, M. C., & Chang, E. B. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00452-2 · Cited by 192 · see citing works
Reduced food anticipatory activity in genetically orexin (hypocretin) neuron‐ablated mice
Akiyama, M., Yuasa, T., Hayasaka, N., Horikawa, K., Sakurai, T., & Shibata, S. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03749.x · Cited by 184 · see citing works
When Clocks Go Bad: Neurobehavioural Consequences of Disrupted Circadian Timing
Barnard, A. R., & Nolan, P. M. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000040 · Cited by 181 · see citing works
Is the food‐entrainable circadian oscillator in the digestive system?
Davidson, A. J., Poole, A. S., Yamazaki, S., & Menaker, M. (2003) · Genes Brain & Behavior · doi:10.1034/j.1601-183x.2003.00005.x · Cited by 180 · see citing works
Staying awake for dinner: hypothalamic integration of sleep, feeding, and circadian rhythms
Saper, C. B. (2006) · Progress in Brain Research · doi:10.1016/s0079-6123(06)53014-6 · Cited by 178 · see citing works
Persistence of a behavioral food-anticipatory circadian rhythm following dorsomedial hypothalamic ablation in rats
Landry, G. J., Simon, M. M., Webb, I. C., & Mistlberger, R. E. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00874.2005 · Cited by 179 · see citing works
Chronobiological aspects of nutrition, metabolic syndrome and obesity
Garaulet, M., & Madrid, J. A. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.05.005 · Cited by 177 · see citing works
Reduced anticipatory locomotor responses to scheduled meals in ghrelin receptor deficient mice
Blum, I. D., Patterson, Z. R., Khazall, R., Lamont, E. W., Sleeman, M., Horváth, T. L., & Abizaid, A. B. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.08.009 · Cited by 174 · see citing works
Central regulation of food intake in fish: an evolutionary perspective
Soengas, J. L., Cerdá‐Reverter, J. M., & Delgado, M. J. (2018) · Journal of Molecular Endocrinology · doi:10.1530/jme-17-0320 · Cited by 165 · see citing works
Hypothalamic Integration of Metabolic, Endocrine, and Circadian Signals in Fish: Involvement in the Control of Food Intake
Delgado, M. J., Cerdá‐Reverter, J. M., & Soengas, J. L. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00354 · Cited by 163 · see citing works
Internal desynchronization in a model of night-work by forced activity in rats
Salgado-Delgado, R., Ángeles-Castellanos, M., Buijs, M. R., & Escobar, C. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.03.066 · Cited by 157 · see citing works
Circadian firing-rate rhythms and light responses of rat habenular nucleus neurons in vivo and in vitro
Zhao, H., & Rusak, B. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.01.012 · Cited by 158 · see citing works
Physiological responses to food intake throughout the day
Johnston, J. D. (2014) · Nutrition Research Reviews · doi:10.1017/s0954422414000055 · Cited by 158 · see citing works
Circadian Rhythms, Aging, and Life Span in Mammals
Froy, O. (2011) · Physiology · doi:10.1152/physiol.00012.2011 · Cited by 156 · see citing works
Circadian modulation by time-restricted feeding rescues brain pathology and improves memory in mouse models of Alzheimer’s disease
Whittaker, D. S., Akhmetova, L., Carlin, D., Romero, H., Welsh, D. K., Colwell, C. S., & Desplats, P. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.07.014 · Cited by 147 · see citing works
The Circadian Clock in White and Brown Adipose Tissue: Mechanistic, Endocrine, and Clinical Aspects
Froy, O., & Garaulet, M. (2018) · Endocrine Reviews · doi:10.1210/er.2017-00193 · Cited by 148 · see citing works
The times they’re a-changing: Effects of circadian desynchronization on physiology and disease
Golombek, D. A., Casiraghi, L. P., Agostino, P. V., Paladino, N., Duhart, J. M., Plano, S. A., & Chiesa, J. J. (2013) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2013.03.007 · Cited by 147 · see citing works
A non-circadian role for clock-genes in sleep homeostasis:a strain comparison
Franken, P., Thomason, R. G., Heller, H. C., & O’Hara, B. F. (2007) · BMC Neuroscience · doi:10.1186/1471-2202-8-87 · Cited by 141 · see citing works
Diurnal Regulation of Microsomal Triglyceride Transfer Protein and Plasma Lipid Levels
Pan, X., & Hussain, M. M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701305200 · Cited by 144 · see citing works
Disruption of Circadian Rhythms: A Crucial Factor in the Etiology of Depression
Salgado‐Delgado, R., Osorio, A. T., Saderi, N., & Escobar, C. (2011) · Depression Research and Treatment · doi:10.1155/2011/839743 · Cited by 144 · see citing works
Entrainment of the master circadian clock by scheduled feeding
Castillo, M. R., Hochstetler, K. J., Tavernier, R. J., Greene, D. M., & Bult‐Ito, A. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00247.2004 · Cited by 141 · see citing works
Effect of feeding regimens on circadian rhythms: Implications for agingand longevity
Froy, O., & Miskin, R. (2010) · Aging · doi:10.18632/aging.100116 · Cited by 141 · see citing works
Circadian Rhythms of the Hypothalamus: From Function to Physiology
Drunen, R. V., & Eckel‐Mahan, K. L. (2021) · Clocks & Sleep · doi:10.3390/clockssleep3010012 · Cited by 138 · see citing works
Diurnal expression of functional and clock-related genes throughout the rat HPA axis: system-wide shifts in response to a restricted feeding schedule
Girotti, M., Weinberg, M. S., & Spencer, R. L. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90946.2008 · Cited by 134 · see citing works
A systematic review of variables associated with sleep paralysis
Denis, D., French, C. C., & Gregory, A. M. (2017) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2017.05.005 · Cited by 133 · see citing works
Differential regulation of the expression of Period2 protein in the limbic forebrain and dorsomedial hypothalamus by daily limited access to highly palatable food in food-deprived and free-fed rats
Verwey, M., Khoja, Z., Stewart, J., & Amir, S. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.04.044 · Cited by 132 · see citing works
Effects of intermittent fasting on health markers in those with type 2 diabetes: A pilot study
Arnason, T., Bowen, M. W., & Mansell, K. D. (2017) · World Journal of Diabetes · doi:10.4239/wjd.v8.i4.154 · Cited by 126 · see citing works
Food-entrained circadian rhythms are sustained in arrhythmic Clk/Clk mutant mice
Pitts, S., Perone, E. A., & Silver, R. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00023.2003 · Cited by 126 · see citing works
Entrainment by a palatable meal induces food-anticipatory activity and c-Fos expression in reward-related areas of the brain
Mendoza, J., Castellanos, A., & Escobar, C. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.01.064 · Cited by 126 · see citing works
Entrainment of circadian clocks in mammals by arousal and food
Mistlberger, R. E., & Antle, M. C. (2011) · Essays in Biochemistry · doi:10.1042/bse0490119 · Cited by 126 · see citing works
Chronobesity: role of the circadian system in the obesity epidemic
Laermans, J., & Depoortere, I. (2015) · Obesity Reviews · doi:10.1111/obr.12351 · Cited by 126 · see citing works
The dorsomedial hypothalamic nucleus is not necessary for food‐anticipatory circadian rhythms of behavior, temperature or clock gene expression in mice
Moriya, T., Aida, R., Kudo, T., Akiyama, M., Doi, M., Hayasaka, N., Nakahata, N., Mistlberger, R. E., Okamura, H., & Shibata, S. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06697.x · Cited by 124 · see citing works
The central circadian timing system
Saper, C. B. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.04.004 · Cited by 123 · see citing works
Seasonal variation of activity patterns in roe deer in a temperate forested area
Pagon, N., Grignolio, S., Pipia, A. P., Bongi, P., Bertolucci, C., & Apollonio, M. (2013) · Chronobiology International · doi:10.3109/07420528.2013.765887 · Cited by 123 · see citing works
Chronobiological aspects of food intake and metabolism and their relevance on energy balance and weight regulation
Ekmekçioğlu, C., & Touitou, Y. (2010) · Obesity Reviews · doi:10.1111/j.1467-789x.2010.00716.x · Cited by 122 · see citing works
From Malthus to motive: How the HPA axis engineers the phenotype, yoking needs to wants
Pecoraro, N. C., Dallman, M. F., Warne, J. P., Ginsberg, A. B., Laugero, K. D., la Fleur, S. E., Houshyar, H., Gómez-Oliver, F., Bhargava, A., & Akana, S. F. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.07.004 · Cited by 120 · see citing works
Functional neuroanatomy of sleep and circadian rhythms
Rosenwasser, A. M. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.08.001 · Cited by 122 · see citing works
Lesion studies targeting food‐anticipatory activity
Davidson, A. J. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06961.x · Cited by 119 · see citing works
The Dorsomedial Hypothalamic Nucleus Is Not Necessary for the Expression of Circadian Food-Anticipatory Activity in Rats
Landry, G. J., Yamakawa, G. R., Webb, I. C., Mear, R. J., & Mistlberger, R. E. (2007) · Journal of Biological Rhythms · doi:10.1177/0748730407307804 · Cited by 120 · see citing works
The Circadian Clock in the Ventromedial Hypothalamus Controls Cyclic Energy Expenditure
Orozco-Solís, R., Aguilar‐Arnal, L., Murakami, M., Peruquetti, R. L., Ramadori, G., Coppari, R., & Sassone‐Corsi, P. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.02.003 · Cited by 116 · see citing works
The dynamics of GABA signaling: Revelations from the circadian pacemaker in the suprachiasmatic nucleus
Albers, H. E., Walton, J. C., Gamble, K. L., McNeill, J. K., & Hummer, D. L. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.11.003 · Cited by 113 · see citing works
Glucocorticoid hormones are both a major circadian signal and major stress signal: How this shared signal contributes to a dynamic relationship between the circadian and stress systems
Spencer, R. L., Chun, L. E., Hartsock, M. J., & Woodruff, E. R. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.12.005 · Cited by 113 · see citing works
Circadian control of the sleep–wake cycle
Beersma, D. G. M., & Gordijn, M. C. M. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.09.010 · Cited by 117 · see citing works
Sympathetic input modulates, but does not determine, phase of peripheral circadian oscillators
Vujović, N., Davidson, A. J., & Menaker, M. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00498.2007 · Cited by 116 · see citing works
Field chronobiology of a molluscan bivalve: how the moon and sun cycles interact to drive oyster activity rhythms
Tran, D., Nadau, A., Durrieu, G., Ciret, P., Parisot, J.-P., & Massabuau, J.-C. (2011) · Chronobiology International · doi:10.3109/07420528.2011.565897 · Cited by 115 · see citing works
Feeding time synchronises daily rhythms of behaviour and digestive physiology in gilthead seabream (Sparus aurata)
Montoya, A., López‐Olmeda, J. F., Yúfera, M., et al. (2010) · Aquaculture · doi:10.1016/j.aquaculture.2010.06.023 · Cited by 115 · see citing works
Experience with the high-intensity sweetener saccharin impairs glucose homeostasis and GLP-1 release in rats
Swithers, S. E., Laboy, A. F., Clark, K., Cooper, S., & Davidson, T. L. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.04.024 · Cited by 113 · see citing works
Robust Food Anticipatory Activity in BMAL1-Deficient Mice
Pendergast, J. S., Nakamura, W., Friday, R. C., Hatanaka, F., Takumi, T., & Yamazaki, S. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004860 · Cited by 113 · see citing works
Food‐entrainable circadian oscillators in the brain
Verwey, M., & Amir, S. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06960.x · Cited by 113 · see citing works
The evolutionary ecology of circadian rhythms in infection
Westwood, M. L., O’Donnell, A. J., de Bekker, C., Lively, C. M., Zuk, M., & Reece, S. E. (2019) · Nature Ecology & Evolution · doi:10.1038/s41559-019-0831-4 · Cited by 109 · see citing works
Direct Regulation of Diurnal Drd3 Expression and Cocaine Reward by NPAS2
Ozburn, A. R., Falcon, E., Twaddle, A., Nugent, A. L., Gillman, A. G., Spencer, S. M., Arey, R. N., Mukherjee, S., Lyons-Weiler, J., Self, D. W., et al. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.07.030 · Cited by 110 · see citing works
Homeostatic and circadian contribution to EEG and molecular state variables of sleep regulation
Curie, T., Mongrain, V., Dorsaz, S., Mang, G. M., Emmenegger, Y., & Franken, P. (2013) · SLEEP · doi:10.5665/sleep.2440 · Cited by 94 · see citing works
Signaling through the ghrelin receptor modulates hippocampal function and meal anticipation in mice
Davis, J. F., Choi, D. L., Clegg, D., & Benoit, S. (2010) · Physiology and Behavior · doi:10.1016/j.physbeh.2010.10.017 · Cited by 110 · see citing works

Zirkadiane Rhythmik und chronische Erkrankungen
Suter, P. M. (2015) · Praxis · doi:10.1024/1661-8157/a002178 · Cited by 1 · see citing works
Gradual changes in environmental light intensity and entrainment of circadian rhythms
Usui, S. (2000) · Brain and Development · doi:10.1016/s0387-7604(00)00146-7 · Cited by 15 · see citing works
Circadian Activity Rhythms of Laboratory Mice during the Last Weeks of their Life
Weinert, H., & Weinert, D. (1998) · Biological Rhythm Research · doi:10.1076/brhm.29.2.159.1444 · Cited by 26 · see citing works
Zeitgeber Hierarchy in Humans: Resetting the Circadian Phase Positions of Blind People Using Melatonin
Lewy, A. J., Emens, J. S., Sack, R. L., Hasler, B. P., & Bernert, R. A. (2003) · Chronobiology International · doi:10.1081/cbi-120024215 · Cited by 40 · see citing works
[Circadian rhythms in man (author's transl)].
Aschoff, J. (1978) · PubMed · Cited by 2 · see citing works

Authors: Stephan, F. K.
Affiliations: Florida State University (US)
Corresponding author: Stephan, F.K.
Venue: Journal of Biological Rhythms
Publisher: SAGE Publications
Published: 2002-08-01
Volume: 17
Issue: 4
Pages: 284-292
ISSN: 0748-7304 (ISSN-L)
0000-0000
DOI: 10.1177/074873002129002591
OpenAlex: W2098459628
Cited by: 672
References: 0
Citations by year: 2026: 15 · 2025: 16 · 2024: 23 · 2023: 24 · 2022: 30 · 2021: 23 · 2020: 45 · 2019: 19 · 2018: 27 · 2017: 32 · 2016: 30 · 2015: 22 · 2014: 38 · 2013: 32 · 2012: 37
FWCI: 5.38
Type: journal article
Language: en
Open access: closed
Locations: Journal of Biological Rhythms (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: food-entrainable oscillator, circadian rhythm, meal timing, clock genes, clock gene expression, suprachiasmatic nucleus, peripheral circadian clock, core body temperature, corticosterone, behavioral activation
MeSH terms: Animals, Brain, Circadian Rhythm, Digestive System Physiological Phenomena, Feeding Behavior

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The “other” circadian system: food as a Zeitgeber

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks