The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Proof of the effect of testosterone on skeletal muscle
Open accessAbstract
In spite of the widespread abuse of androgenic steroids by athletes and recreational body-builders, the effects of these agents on athletic performance and physical function remain poorly understood. Experimentally induced androgen deficiency is associated with a loss of fat-free mass; conversely, physiologic testosterone replacement of healthy, androgen-deficient men increases fat-free mass and muscle protein synthesis. Testosterone supplementation of HIV-infected men with low testosterone levels and of older men with normally low testosterone concentrations also increases muscle mass. However, we do not know whether physiologic testosterone replacement can improve physical function and health-related quality of life, and reduce the risk of falls and disability in older men or those with chronic illness. Testosterone increases maximal voluntary strength in a dose-dependent manner and thus might improve performance in power-lifting events. However, testosterone has not been shown to improve performance in endurance events. The mechanisms by which testosterone increases muscle mass are not known, but probably involve alterations in the expression of multiple muscle growth regulators.
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Cites
Effects of testosterone supplementation in the aging male
Tenover, J. S. (1992) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.75.4.1092 · Cited by 768
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Dronabinol as a treatment for anorexia associated with weight loss in patients with AIDS
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Effects of Testosterone Replacement in Hypogonadal Men
Snyder, P. J. (2000) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.8.2670 · Cited by 464
Fryburg, D. A., Weltman, A., Jahn, L. A., Weltman, J. Y., Samojlik, E., Hintz, R. L., & Veldhuis, J. D. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.11.4379 · Cited by 64
Cited by
Singh, R., Artaza, J. N., Taylor, W. E., Gonzalez-Cadavid, N. F., & Bhasin, S. (2003) · Endocrinology · doi:10.1210/en.2003-0741 · Cited by 555
Self-citationMalkin, C. J., Pugh, P. J., West, J. N., van Beek, E. J. R., Jones, T. H., & Channer, K. S. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehi443 · Cited by 413
Sinha-Hikim, I., Roth, S. M., Lee, M. I., & Bhasin, S. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00370.2002 · Cited by 344
Self-citationThe insults of illicit drug use on male fertility
Fronczak, C. M., Kim, E. D., & Barqawi, A. B. (2012) · Journal of Andrology · doi:10.2164/jandrol.110.011874 · Cited by 217
Mangine, G. T., Hoffman, J. R., Gonzalez, A. M., Townsend, J. R., Wells, A. J., Jajtner, A. R., Beyer, K. S., Boone, C. H., Miramonti, A. A., Wang, R., et al. (2015) · Physiological Reports · doi:10.14814/phy2.12472 · Cited by 204
Metadata
- Authors
- Bhasin, S., Woodhouse, L., & Storer, T.
- Venue
- Journal of Endocrinology
- Publisher
- Bioscientifica
- Published
- 2001-07-01
- Volume
- 170
- Issue
- 1
- Pages
- 27-38
- ISSN
- 0022-0795 (ISSN-L)
- 1479-6805
- OpenAlex
- W2119740932
- Cited by
- 293
- References
- 5
- FWCI
- 7.67
- Type
- journal article
- Language
- en
- Open access
- bronze
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