The DOI matches its Crossref record; 71 of the 72 references it cites were found in a registry or an index.
Effects and applications of arthropod steroid hormones (ecdysteroids) in mammals
Open accessAbstract
Zooecdysteroids (arthropod steroid hormones) regulate the development of arthropods and probably many other invertebrates. Phytoecdysteroids are analogues occurring in a wide range of plant species, where they contribute to the deterrence of phytophagous invertebrates. The purpose of this short review is to summarise findings on the occurrence, metabolism and pharmacological effects of ecdysteroids in mammalian systems and to draw attention to their potential applications, particularly in gene-switch technology, where ecdysteroid analogues (steroidal and non-steroidal) can be used as effective and potent elicitors.
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“Even ECD is not produced in mammalian tissues and has several physiological effects in mammals when taken externally [5].”
In the citing paper
“The Ecd is frequently used by body builders and from these users it is known that Ecd has no known adverse effects even when taken up in gram (~1 g) quantities [16].”
From Arthropod steroid hormone (20-Hydroxyecdysone) suppresses IL-1β- induced catabolic gene expression in cartilage (2015) · cites this paper as [16]
In the citing paper
“Cyanotis vaga and Cyanotis arachnoidea belong to monocot species, and several species of ferns that belong to Polypodium are rich sources of ECs [7,8,30,31,32,33,34,35].”
From Phytoecdysteroids: Distribution, Structural Diversity, Biosynthesis, Activity, and Crosstalk with Phytohormones (2022) · cites this paper as [33]
In the citing paper
“The taxons that are used in traditional medicines such as Leuzea carthamoides, Ajuga turkestanica, and several Pfaffia species have abundant ECs in their roots.”
From Phytoecdysteroids: Distribution, Structural Diversity, Biosynthesis, Activity, and Crosstalk with Phytohormones (2022) · cites this paper as [33]
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Citations
Cites
Molecular and cellular endocrinology
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Functional ecdysone receptor is the product of EcR and Ultraspiracle genes
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Phytoecdysteroids: Biological aspects
Dinan, L. (2001) · Phytochemistry · doi:10.1016/s0031-9422(01)00078-4 · Cited by 392 · cited 1×
“Ecdysteroids are also present in 5–6% of plant species (Dinan 1995a), generally at far higher concentrations than those typically found in arthropods, where they are regarded as contributing to the deterrence of invertebrate predators (Lafont et al. 1991, Dinan 2001).”
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1 of the 72 references couldn’t be matched to a known paper.
Research works printed but not linked: 8
- Brandt F 2003 Pharmakokinetik und metabolismus des 20-Hydroxyecdysons im menschen. PhD Thesis, University of Marburg (Germany).
- Detmar M, Dumas M, Bonte ´F, Meybeck A & Orfanos CE 1994 Effects of ecdysterone on the differentiation of normal human keratinocytes in vitro. European Journal of Dermatology 4 558-569.
- Dinan L 1995a A strategy for the identification of ecdysteroid receptor agonists and antagonists from plants. European Journal of Entomology 92 271-283.
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- Eds LI Gilbert, K Iatrou & SS Gill. Oxford: Elsevier Pergamon.
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- Eds LI Gilbert, K Iatrou & SS Gill. Oxford: Elsevier Pergamon.
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Metabolic and Hormonal Modulation by Phytoecdysteroids in Mammals
Lafont, R. (2026) · Springer eBooks · doi:10.1007/978-981-95-8423-9_3
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Metadata
- Authors
- Dinan, L., & Lafont, R.
- Affiliations
- University of Exeter (GB)
- ORCID
- Dinan, Laurence
- Venue
- Journal of Endocrinology
- Publisher
- Bioscientifica
- Published
- 2006-10
- Volume
- 191
- Issue
- 1
- Pages
- 1-8
- ISSN
- 0022-0795 (ISSN-L)
- 1479-6805
- OpenAlex
- W2107130601
- Cited by
- 200
- References
- 72
- Citations by year
- 2026: 7 · 2025: 2 · 2024: 5 · 2023: 9 · 2022: 10 · 2021: 22 · 2020: 14 · 2019: 13 · 2018: 14 · 2017: 8 · 2016: 11 · 2015: 8 · 2014: 12 · 2013: 7 · 2012: 10
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Leverhulme Trust
- Ministère de l'Education Nationale, de l'Enseignement Supérieur et de la Recherche
- Centre National de la Recherche Scientifique
- Biotechnology and Biological Sciences Research Council
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Steroid Chemistry and Biochemistry
- Physical Sciences › Chemistry › Organic Chemistry › Phytochemical Studies and Bioactivities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Keywords
- ecdysteroids, phytoecdysteroids, elicitors, plant defense against herbivores
- MeSH terms
- Animals, Gene Expression Regulation, Humans, Mammals, Phytotherapy, Phytosterols, Plants, Proteins, Dietary Supplements, Ecdysteroids, Carbohydrate Metabolism, Lipid Metabolism
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