The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Detection of Renal Function Decline in Patients with Diabetes and Normal or Elevated GFR by Serial Measurements of Serum Cystatin C Concentration: Results of a 4-Year Follow-Up Study
Open accessAbstract
Research on early renal function decline in diabetes is hampered by lack of simple tools for detecting trends (particularly systematic decreases) in renal function over time when GFR is normal or elevated. This study sought to assess how well serum cystatin C meets that need. Thirty participants with type 2 diabetes in the Diabetic Renal Disease Study met these three eligibility criteria: GFR >20 ml/min per 1.73 m2 at baseline (based on cold iothalamate clearance), 4 yr of follow-up, and yearly measurements of iothalamate clearance and serum cystatin C. With the use of linear regression, each individual's trend in renal function over time, expressed as annual percentage change in iothalamate clearance, was determined. Serum cystatin C in mg/L was transformed to its reciprocal (100/cystatin C), and linear regression was used to determine each individual's trend over time, expressed as annual percentage change. In paired comparisons of 100/cystatin C with iothalamate clearance at each examination, the two measures were numerically similar. More important, the trends in 100/cystatin C and iothalamate clearance were strongly correlated (Spearman r = 0.77). All 20 participants with negative trends in iothalamate clearance (declining renal function) also had negative trends for 100/cystatin C. Results were discordant for only three participants. In contrast, the trends for three commonly used creatinine-based estimates of GFR compared poorly with trends in iothalamate clearance (Spearman r < 0.35). Serial measures of serum cystatin C accurately detect trends in renal function in patients with normal or elevated GFR and provide means for studying early renal function decline in diabetes.
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Self-citationSerum cystatin C is superior to serum creatinine as a marker of kidney function: A meta-analysis
Dharnidharka, V. R., Kwon, C., & Stevens, G. (2002) · American Journal of Kidney Diseases · doi:10.1053/ajkd.2002.34487 · Cited by 1,663
Longitudinal Studies on the Rate of Decline in Renal Function with Age
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Goodpasture syndrome during the course of a Schönlein-Henoch purpura
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Cystatin C: An Improved Estimator of Glomerular Filtration Rate?
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Chronic Kidney Disease: Effects on the Cardiovascular System
Schiffrin, E. L., Lipman, M. L., & Mann, J. F. E. (2007) · Circulation · doi:10.1161/circulationaha.106.678342 · Cited by 1,448
Temporal trends in the prevalence of diabetic kidney disease in the United States
de Boer, I. H. (2011) · JAMA · doi:10.1001/jama.2011.861 · Cited by 1,036
Glomerular hyperfiltration in diabetes: mechanisms, clinical significance, and treatment
Tonneijck, L., Muskiet, M. H. A., Smits, M. M., van Bommel, E. J., Heerspink, H. J. L., van Raalte, D. H., & Joles, J. A. (2017) · Journal of the American Society of Nephrology · doi:10.1681/asn.2016060666 · Cited by 887
Thompson, D. M., Meloche, M., Ao, Z., Paty, B., Keown, P., Shapiro, R. J., Ho, S., Worsley, D., Fung, M., Meneilly, G., et al. (2011) · Transplantation · doi:10.1097/tp.0b013e31820437f3 · Cited by 213
Association of urinary inflammatory markers and renal decline in microalbuminuric type 1 diabetics
Wolkow, P. P., Niewczas, M. A., Perkins, B., Ficociello, L. H., Lipinski, B., Warram, J. H., & Krolewski, A. S. (2008) · Journal of the American Society of Nephrology · doi:10.1681/asn.2007050556 · Cited by 155
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Metadata
- Authors
- Perkins, B. A., Nelson, R. G., Ostrander, B. E. P., Blouch, K. L., Krolewski, A. S., Myers, B. D., & Warram, J. H.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2005-05
- Volume
- 16
- Issue
- 5
- Pages
- 1404-1412
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2105258594
- Cited by
- 323
- References
- 32
- FWCI
- 18.26
- Type
- journal article
- Language
- en
- Open access
- green
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- Perkins, B. A., Nelson, R. G., Ostrander, B. E. P., Blouch, K. L., Krolewski, A. S., Myers, B. D., & Warram, J. H. (2005). Detection of Renal Function Decline in Patients with Diabetes and Normal or Elevated GFR by Serial Measurements of Serum Cystatin C Concentration: Results of a 4-Year Follow-Up Study. Journal of the American Society of Nephrology. https://doi.org/10.1681/asn.2004100854
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