The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Molecular Control of Iron Transport
Abstract
The iron-regulatory hormone hepcidin is a 25-amino acid peptide that is synthesized in hepatocytes. Hepcidin binds to the cellular iron export channel ferroportin and causes its internalization and degradation and thereby decreases iron efflux from iron exporting tissues into plasma. By this mechanism, hepcidin inhibits dietary iron absorption, the efflux of recycled iron from splenic and hepatic macrophages, and the release of iron from storage in hepatocytes. Hepcidin synthesis is stimulated by plasma iron and iron stores and is inhibited by erythropoietic activity, ensuring that extracellular plasma iron concentrations and iron stores remain stable and the erythropoietic demand for iron is met. During inflammation, increased hepcidin concentrations cause iron sequestration in macrophages, resulting in hypoferremia and eventually anemia of inflammation. Hepcidin deficiency plays a central role in most iron overload disorders. The role of hepcidin abnormalities in anemias that are associated with renal disease and in resistance to erythropoietic therapies remains to be elucidated.
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In the citing paper
“and lead to reduced ferroportin surface expression and hypoferremia”
From Regulation of erythropoiesis by hypoxia-inducible factors (2013) · cites this paper as [188]
In the citing paper
“Hepcidin suppresses intestinal iron uptake and release of iron from internal stores by facilitating the degradation and internalization of the only known cellular iron exporter, ferroportin”
From Regulation of erythropoiesis by hypoxia-inducible factors (2013) · cites this paper as [188]
In the citing paper
“lending support to the notion that hepcidin has a key role in the pathogenesis of anemia of chronic disease.”
From Regulation of erythropoiesis by hypoxia-inducible factors (2013) · cites this paper as [188]
In the citing paper
“Chronically elevated serum hepcidin levels are frequently associated with inflammatory states”
From Regulation of erythropoiesis by hypoxia-inducible factors (2013) · cites this paper as [188]
In the citing paper
“(interleukin-6 induces hepcidin transcription via JAK/STAT signaling)”
From Regulation of erythropoiesis by hypoxia-inducible factors (2013) · cites this paper as [188]
Citations
Cites
Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
Nemeth, E., Tuttle, M. S., Powelson, J., Vaughn, M. B., Donovan, A., Ward, D. M., Ganz, T., & Kaplan, J. (2004) · Science · doi:10.1126/science.1104742 · Cited by 4,803
Self-citationNemeth, E., Rivera, S., Gabayan, V., Keller, C., Taudorf, S., Pedersen, B. K., & Ganz, T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420945 · Cited by 2,650 · cited 9×
“Although the acute hypoferremic response and hepcidin induction both are impaired in IL-6–deficient mice (21), chronic inflammatory stimulation elicits hepcidin even in IL-6–deficient mice (31).”
BackgroundInfluentialSelf-citationHepcidin, a urinary antimicrobial peptide synthesized in the liver
Park, C. H., Valore, E. V., Waring, A. J., & Ganz, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008922200 · Cited by 2,168
Self-citationPigeon, C., Ilyin, G., Courselaud, B., Leroyer, P., Turlin, B., Brissot, P., & Loréal, O. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008923200 · Cited by 1,697
Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
Donovan, A., Brownlie, A., Zhou, Y., Shepard, J., Pratt, S. J., Moynihan, J., Paw, B. H., Drejer, A., Barut, B., Zapata, A., et al. (2000) · Nature · doi:10.1038/35001596 · Cited by 1,667
McKie, A. T., Marciani, P., Rolfs, A., Brennan, K., Wehr, K., Barrow, D., Miret, S., Bomford, A., Peters, T. J., Farzaneh, F., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80425-6 · Cited by 1,422
Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
Nemeth, E., Valore, E. V., Territo, M., Schiller, G., Lichtenstein, A., & Ganz, T. (2003) · Blood · doi:10.1182/blood-2002-10-3235 · Cited by 1,417
LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity
Krause, A., Neitz, S., Mägert, H.-J., Schulz, A., Forssmann, W.-G., Schulz-Knappe, P., & Adermann, K. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01920-7 · Cited by 1,324
The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis
Donovan, A., Lima, C. A., Pinkus, J. L., Pinkus, G. S., Zon, L. I., Robine, S., & Andrews, N. C. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.01.003 · Cited by 1,275
A Novel Mammalian Iron-regulated Protein Involved in Intracellular Iron Metabolism
Abboud, S., & Haile, D. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000713200 · Cited by 1,267
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“[15], that ferroportin is the likely cause of ferritin degradation and found that mice lacking ferroportin, displayed anaemia and iron overload due to the lowered export of iron from both macrophages and enterocytes [28].”
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IN TRANSLATION Molecular Mechanisms of Hepcidin Regulation: Implications for the Anemia of CKD
Babitt, J. L., & Lin, H. Y.-F. (2010)
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“Production of hepcidin is increased in relation to inflammation(19).”
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Metadata
- Authors
- Ganz, T.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Ganz, Tomas
- ORCID
- Ganz, Tomas
- Venue
- Journal of the American Society of Nephrology
- Published
- 2007-02
- Volume
- 18
- Issue
- 2
- Pages
- 394-400
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2120359196
- Cited by
- 353
- References
- 58
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 8 · 2023: 9 · 2022: 15 · 2021: 30 · 2020: 13 · 2019: 17 · 2018: 17 · 2017: 12 · 2016: 19 · 2015: 22 · 2014: 17 · 2013: 22 · 2012: 18
- FWCI
- 23.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Society of Nephrology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL046809, HL46809)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
- Keywords
- hepcidin, iron transport, ferroportin, iron homeostasis, dietary iron absorption, iron storage, erythropoiesis, inflammation, anemia of chronic disease, iron overload, anemia of chronic kidney disease
- MeSH terms
- Ferroportin, Anemia, Biological Transport, Bone and Bones, Homeostasis, Humans, Inflammation, Intestinal Absorption, Iron, Kidney Diseases, Kinetics, Liver, Iron Overload, Antimicrobial Cationic Peptides, Cation Transport Proteins, Hepcidins
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