The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
C5a Receptor Mediates Neutrophil Activation and ANCA-Induced Glomerulonephritis
Open accessAbstract
Anti-neutrophil cytoplasmic autoantibody (ANCA)-induced necrotizing crescentic glomerulonephritis (NCGN) requires complement participation in its pathogenesis. We tested the hypothesis that the anaphylatoxin C5a is pivotal to disease induction via the neutrophil C5a receptor (C5aR). Supernatants from ANCA-activated neutrophils activated the complement cascade in normal serum, producing C5a. This conditioned serum primed neutrophils for ANCA-induced respiratory burst; neutrophil C5aR blockade abrogated this priming, but C3aR blockade did not. Furthermore, recombinant C5a but not C3a dosage-dependently primed neutrophils for ANCA-induced respiratory burst. To test the role of C5aR in a model of NCGN, we immunized myeloperoxidase-deficient mice with myeloperoxidase, irradiated them, and transplanted bone marrow from wild-type mice or C5aR-deficient mice into them. All mice that received wild-type marrow (six of six) but only one of eight mice that received C5aR-deficient marrow developed NCGN (P < 0.05). Albuminuria and neutrophil influx into glomeruli were also significantly attenuated in the mice that received C5aR-deficient marrow (P < 0.05). In summary, C5a and the neutrophil C5aR may compose an amplification loop for ANCA-mediated neutrophil activation. The C5aR may provide a new therapeutic target for ANCA-induced necrotizing crescentic glomerulonephritis.
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Functional roles for C5a receptors in sepsis
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The Role of Neutrophils in the Induction of Glomerulonephritis by Anti-Myeloperoxidase Antibodies
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Neutrophil chemoattractant receptors in health and disease: Double-edged swords
Metzemaekers, M., Gouwy, M., & Proost, P. (2020) · Cellular & Molecular Immunology · doi:10.1038/s41423-020-0412-0 · Cited by 570
Complement in Immune and Inflammatory Disorders: Pathophysiological Mechanisms
Ricklin, D., & Lambris, J. D. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203487 · Cited by 478
The renaissance of complement therapeutics
Ricklin, D., Mastellos, D. C., Reis, E. S., & Lambris, J. D. (2018) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.156 · Cited by 379
C5a Receptor (CD88) Blockade Protects against MPO-ANCA GN
Xiao, H., Dairaghi, D. J., Powers, J. P., Ertl, L. S., Baumgart, T., Wang, Y., Seitz, L. C., Penfold, M. E. T., Gan, L., Hu, P., et al. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2013020143 · Cited by 353
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Metadata
- Authors
- Schreiber, A., Xiao, H., Jennette, J. C., Schneider, W., Luft, F. C., & Kettritz, R.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2009-02
- Volume
- 20
- Issue
- 2
- Pages
- 289-298
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2104599968
- Cited by
- 451
- References
- 29
- FWCI
- 4.84
- Type
- journal article
- Language
- en
- Open access
- green
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