The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
C5a Receptor (CD88) Blockade Protects against MPO-ANCA GN
Open accessAbstract
Necrotizing and crescentic GN (NCGN) with a paucity of glomerular immunoglobulin deposits is associated with ANCA. The most common ANCA target antigens are myeloperoxidase (MPO) and proteinase 3. In a manner that requires activation of the alternative complement pathway, passive transfer of antibodies to mouse MPO (anti-MPO) induces a mouse model of ANCA NCGN that closely mimics human disease. Here, we confirm the importance of C5aR/CD88 in the mediation of anti-MPO-induced NCGN and report that C6 is not required. We further demonstrate that deficiency of C5a-like receptor (C5L2) has the reverse effect of C5aR/CD88 deficiency and results in more severe disease, indicating that C5aR/CD88 engagement enhances inflammation and C5L2 engagement suppresses inflammation. Oral administration of CCX168, a small molecule antagonist of human C5aR/CD88, ameliorated anti-MPO-induced NCGN in mice expressing human C5aR/CD88. These observations suggest that blockade of C5aR/CD88 might have therapeutic benefit in patients with ANCA-associated vasculitis and GN.
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Xiao, H., Heeringa, P., Hu, P., Liu, Z., Zhao, M., Aratani, Y., Maeda, N., Falk, R. J., & Jennette, J. C. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15918 · Cited by 1,005
Self-citationXiao, H., Heeringa, P., Hu, P., Liu, Z., Zhao, M., Aratani, Y., Maeda, N., Falk, R. J., & Jennette, J. C. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215918 · Cited by 919
Self-citationXiao, H., Schreiber, A., Heeringa, P., Falk, R. J., & Jennette, J. C. (2007) · The American Journal of Pathology · doi:10.2353/ajpath.2007.060573 · Cited by 579
Self-citationPredominant role for C5b-9 in renal ischemia/reperfusion injury
Zhou, W., Farrar, C. A., Abe, K., Pratt, J. R., Marsh, J. E., Wang, Y., Stahl, G. L., & Sacks, S. H. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8621 · Cited by 465
Self-citationC5a Receptor Mediates Neutrophil Activation and ANCA-Induced Glomerulonephritis
Schreiber, A., Xiao, H., Jennette, J. C., Schneider, W., Luft, F. C., & Kettritz, R. (2009) · Journal of the American Society of Nephrology · doi:10.1681/asn.2008050497 · Cited by 451
Self-citationThe complement system in systemic autoimmune disease
Chen, M., Daha, M. R., & Kallenberg, C. G. M. (2010) · Journal of Autoimmunity · doi:10.1016/j.jaut.2009.11.014 · Cited by 327
Huugen, D., van Esch, A., Xiao, H., Peutz-Kootstra, C.-J., Buurman, W.-A., Tervaert, J. W. C., Jennette, J.-C., & Heeringa, P. (2007) · Kidney International · doi:10.1038/sj.ki.5002103 · Cited by 249
Self-citationThe C5a Receptor (C5aR) C5L2 Is a Modulator of C5aR-mediated Signal Transduction
Bamberg, C. E., Mackay, C. R., Lee, H., Zahra, D., Jackson, J., Lim, Y. S., Whitfeld, P. L., Craig, S., Corsini, E., Lu, B., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.092106 · Cited by 249
Self-citationPathogenesis of Antineutrophil Cytoplasmic Autoantibody–Associated Small-Vessel Vasculitis
Jennette, J. C., Falk, R. J., Hu, P., & Xiao, H. (2013) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-011811-132453 · Cited by 243
Self-citationAn Anti-inflammatory Function for the Complement Anaphylatoxin C5a-binding Protein, C5L2
Gerard, N. P., Lu, B., Liu, P., Craig, S., Fujiwara, Y., Okinaga, S., & Gerard, C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.c500287200 · Cited by 201
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RETRACTED: Avacopan for the Treatment of ANCA-Associated Vasculitis
Jayne, D. R. W., Merkel, P. A., Schall, T. J., & Bekker, P. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2023386 · Cited by 1,021
Self-citationRetractedThe renaissance of complement therapeutics
Ricklin, D., Mastellos, D. C., Reis, E. S., & Lambris, J. D. (2018) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.156 · Cited by 379
Metadata
- Authors
- Xiao, H., Dairaghi, D. J., Powers, J. P., Ertl, L. S., Baumgart, T., Wang, Y., Seitz, L. C., Penfold, M. E. T., Gan, L., Hu, P., Lu, B., Gerard, N. P., Gerard, C., Schall, T. J., Jaen, J. C., Falk, R. J., & Jennette, J. C.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2014-02
- Volume
- 25
- Issue
- 2
- Pages
- 225-231
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2143558168
- Cited by
- 353
- References
- 18
- FWCI
- 17.29
- Type
- journal article
- Language
- en
- Open access
- green
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- Xiao, H., Dairaghi, D. J., Powers, J. P., Ertl, L. S., Baumgart, T., Wang, Y., Seitz, L. C., Penfold, M. E. T., Gan, L., Hu, P., Lu, B., Gerard, N. P., Gerard, C., Schall, T. J., Jaen, J. C., Falk, R. J., & Jennette, J. C. (2014). C5a Receptor (CD88) Blockade Protects against MPO-ANCA GN. Journal of the American Society of Nephrology. https://doi.org/10.1681/asn.2013020143
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