The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
IL-10/TGF-β–Modified Macrophages Induce Regulatory T Cells and Protect against Adriamycin Nephrosis
Open accessAbstract
IL-10/TGF-beta-modified macrophages, a subset of activated macrophages, produce anti-inflammatory cytokines, suggesting that they may protect against inflammation-mediated injury. Here, macrophages modified ex vivo by IL-10/TGF-beta (IL-10/TGF-beta Mu2) significantly attenuated renal inflammation, structural injury, and functional decline in murine adriamycin nephrosis (AN). These cells deactivated effector macrophages and inhibited CD4+ T cell proliferation. IL-10/TGF-beta Mu2 expressed high levels of the regulatory co-stimulatory molecule B7-H4, induced regulatory T cells from CD4+CD25- T cells in vitro, and increased the number of regulatory T cells in lymph nodes draining the kidneys in AN. The phenotype of IL-10/TGF-beta Mu2 did not switch to that of effector macrophages in the inflamed kidney, and these cells did not promote fibrosis. Taken together, these data demonstrate that IL-10/TGF-beta-modified macrophages effectively protect against renal injury in AN and may become part of a therapeutic strategy for chronic inflammatory disease.
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Cites
The chemokine system in diverse forms of macrophage activation and polarization
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The many faces of macrophage activation
Mosser, D. M. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0602325 · Cited by 1,902 · cited 1×
“Our study thus reveals two novel observations about B7-H4 and IL-10/TGF- –modified macrophages: (1) IL-10/TGF- – modified macrophages can be distinguished from IL-4/13modified macrophages by their high level expression of B7-H4; and (2) B7-H4 on IL-10/TGF- –modified macrophages not only suppresses T cell proliferation…”
Functional plasticity of macrophages: reversible adaptation to changing microenvironments
Stout, R. D., & Suttles, J. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0504272 · Cited by 751
B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma
Kryczek, I., Zou, L., Rodriguez, P., Zhu, G., Wei, S., Mottram, P., Brumlik, M., Cheng, P., Curiel, T., Myers, L., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20050930 · Cited by 748
Cited by
Macrophages in Tissue Repair, Regeneration, and Fibrosis
Wynn, T. A., & Vannella, K. M. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.015 · Cited by 4,481
Mechanisms of Organ Injury and Repair by Macrophages
Vannella, K. M., & Wynn, T. A. (2017) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022516-034356 · Cited by 656
Mikita, J., Dubourdieu-Cassagno, N., Deloire, M. S., Vekris, A., Biran, M., Raffard, G., Brochet, B., Canron, M.-H., Franconi, J.-M., Boiziau, C., et al. (2011) · Multiple Sclerosis Journal · doi:10.1177/1352458510379243 · Cited by 358
Ma, P.-F., Gao, C.-C., Yi, J., Zhao, J.-L., Liang, S.-Q., Zhao, Y., Ye, Y.-C., Bai, J., Zheng, Q.-J., Dou, K.-F., et al. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.05.022 · Cited by 284
Lu, J., Cao, Q., Zheng, D., Sun, Y., Wang, C., Yu, X., Wang, Y., Lee, V. W. S., Zheng, G., Tan, T. K., et al. (2013) · Kidney International · doi:10.1038/ki.2013.135 · Cited by 242
Self-citation
Metadata
- Authors
- Cao, Q., Wang, Y., Zheng, D., Sun, Y., Wang, Y., Lee, V. W. S., Zheng, G., Tan, T. K., Ince, J., Alexander, S. I., & Harris, D. C. H.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2010-06
- Volume
- 21
- Issue
- 6
- Pages
- 933-942
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2165909284
- Cited by
- 278
- References
- 7
- FWCI
- 10.15
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: IL-10/TGF-β–Modified Macrophages Induce Regulatory T Cells and Protect against Adriamycin Nephrosis. https://app.cochat.ai/papers/10.1681/asn.2009060592
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- Cao, Q., Wang, Y., Zheng, D., Sun, Y., Wang, Y., Lee, V. W. S., Zheng, G., Tan, T. K., Ince, J., Alexander, S. I., & Harris, D. C. H. (2010). IL-10/TGF-β–Modified Macrophages Induce Regulatory T Cells and Protect against Adriamycin Nephrosis. Journal of the American Society of Nephrology. https://doi.org/10.1681/asn.2009060592
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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