The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
EGFR Signaling Promotes TGFβ-Dependent Renal Fibrosis
Open accessAbstract
The mechanisms by which angiotensin II (Ang II) promotes renal fibrosis remain incompletely understood. Ang II both stimulates TGFβ signaling and activates the EGF receptor (EGFR), but the relative contribution of these pathways to renal fibrogenesis is unknown. Using a murine model with EGFR-deficient proximal tubules, we demonstrate that upstream activation of EGFR-dependent ERK signaling is critical for mediating sustained TGFβ expression in renal fibrosis. Persistent activation of the Ang II receptor stimulated ROS-dependent phosphorylation of Src, leading to sustained EGFR-dependent signaling for TGFβ expression. Either genetic or pharmacologic inhibition of EGFR significantly decreased TGFβ-mediated fibrogenesis. We conclude that TGFβ-mediated tissue fibrosis relies on a persistent feed-forward mechanism of EGFR/ERK activation through an unexpected signaling pathway, highlighting EGFR as a potential therapeutic target for modulating tissue fibrogenesis.
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Cites
Regulation of Wound Healing by Growth Factors and Cytokines
WERNER, S., & GROSE, R. (2003) · Physiological Reviews · doi:10.1152/physrev.2003.83.3.835 · Cited by 3,629
Epithelial-mesenchymal transition and its implications for fibrosis
Kalluri, R., & Neilson, E. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200320530 · Cited by 2,649
Self-citationBiomarkers for epithelial-mesenchymal transitions
Zeisberg, M., & Neilson, E. G. (2009) · Journal of Clinical Investigation · doi:10.1172/jci36183 · Cited by 2,299
Self-citationEvidence that fibroblasts derive from epithelium during tissue fibrosis
Iwano, M., Plieth, D., Danoff, T. M., Xue, C., Okada, H., & Neilson, E. G. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215518 · Cited by 1,590
Self-citationSignal Transduction by the TGF-β Superfamily
Attisano, L., & Wrana, J. L. (2002) · Science · doi:10.1126/science.1071809 · Cited by 1,268
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New Insights into Epithelial-Mesenchymal Transition in Kidney Fibrosis
Liu, Y. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2008121226 · Cited by 870
Mechanisms of Tubulointerstitial Fibrosis
Zeisberg, M., & Neilson, E. G. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2010080793 · Cited by 868
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Cited by
TGF-β: the master regulator of fibrosis
Meng, X.-M., Nikolic-Paterson, D. J., & Lan, H. Y. (2016) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.48 · Cited by 3,528
Fibrosis–a common pathway to organ injury and failure
Rockey, D. C., Bell, P. D., & Hill, J. A. (2015) · New England Journal of Medicine · doi:10.1056/nejmra1300575 · Cited by 1,428
Single-cell technologies in hepatology: new insights into liver biology and disease pathogenesis
Ramachandran, P., Matchett, K. P., Dobie, R., Wilson-Kanamori, J. R., & Henderson, N. C. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0304-x · Cited by 253
FOXM1 drives proximal tubule proliferation during repair from acute ischemic kidney injury
Chang-Panesso, M., Kadyrov, F. F., Lalli, M., Wu, H., Ikeda, S., Kefaloyianni, E., Abdelmageed, M. M., Herrlich, A., Kobayashi, A., & Humphreys, B. D. (2019) · Journal of Clinical Investigation · doi:10.1172/jci125519 · Cited by 158
Hammoud, S. H., AlZaim, I., Al-Dhaheri, Y., Eid, A. H., & El-Yazbi, A. F. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.707126 · Cited by 87
Metadata
- Authors
- Chen, J., Chen, J.-K., Nagai, K., Plieth, D., Tan, M., Lee, T.-C., Threadgill, D. W., Neilson, E. G., & Harris, R. C.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2012-02
- Volume
- 23
- Issue
- 2
- Pages
- 215-224
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2169981609
- Cited by
- 285
- References
- 33
- FWCI
- 5.05
- Type
- journal article
- Language
- en
- Open access
- green
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- Chen, J., Chen, J.-K., Nagai, K., Plieth, D., Tan, M., Lee, T.-C., Threadgill, D. W., Neilson, E. G., & Harris, R. C. (2012). EGFR Signaling Promotes TGFβ-Dependent Renal Fibrosis. Journal of the American Society of Nephrology. https://doi.org/10.1681/asn.2011070645
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
