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Cited by 201Dialysis and Renal Disease ManagementCholesterol and Lipid MetabolismAtherosclerosis and Cardiovascular Diseases

The DOI matches its Crossref record; 81 of the 81 references it cites were found in a registry or an index.

Serum Amyloid A in Uremic HDL Promotes Inflammation

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Weichhart, Thomas, Kopecky, Chantal, Kubicek, Markus, Haidinger, Michael, Döller, Dominik, Katholnig, Karl, Suarna, Cacang, Eller, Philipp, Tölle, Markus, Gerner, Christopher, Zlabinger, Gerhard J., van der Giet, Markus, Hörl, Walter H., Stocker, Roland, Säemann, Marcus D.·2012·Journal of the American Society of Nephrology
DOI 10.1681/asn.2011070668PMC PMC3338291
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Abstract

Uremia impairs the atheroprotective properties of HDL, but the mechanisms underlying why this occurs are unknown. Here, we observed that HDL isolated from healthy individuals inhibited the production of inflammatory cytokines by peripheral monocytes stimulated with a Toll-like receptor 2 agonist. In contrast, HDL isolated from the majority of patients with ESRD did not show this anti-inflammatory property; many HDL samples even promoted the production of inflammatory cytokines. To investigate this difference, we used shotgun proteomics to identify 49 HDL-associated proteins in a uremia-specific pattern. Proteins enriched in HDL from patients with ESRD (ESRD-HDL) included surfactant protein B (SP-B), apolipoprotein C-II, serum amyloid A (SAA), and α-1-microglobulin/bikunin precursor. In addition, we detected some ESRD-enriched proteins in earlier stages of CKD. We did not detect a difference in oxidation status between HDL isolated from uremic and healthy patients. Regarding function of these uremia-specific proteins, only SAA mimicked ESRD-HDL by promoting inflammatory cytokine production. Furthermore, SAA levels in ESRD-HDL inversely correlated with its anti-inflammatory potency. In conclusion, HDL has anti-inflammatory activities that are defective in uremic patients as a result of specific changes in its molecular composition. These data suggest a potential link between the high levels of inflammation and cardiovascular mortality in uremia.

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Crossref · 10.1681/asn.2011070668

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Authors
Weichhart, T., Kopecky, C., Kubicek, M., Haidinger, M., Döller, D., Katholnig, K., Suarna, C., Eller, P., Tölle, M., Gerner, C., Zlabinger, G. J., van der Giet, M., Hörl, W. H., Stocker, R., & Säemann, M. D.
Affiliations
  • Medical University of Vienna (AT)
  • The University of Sydney (AU)
  • Medical University of Graz (AT)
  • Charité – Universitätsmedizin Berlin (DE)
  • Comprehensive Cancer Center Vienna (AT)
Corresponding author
  • Weichhart, Thomas
  • Kopecky, Chantal
  • Haidinger, Michael
  • Döller, Dominik
  • Katholnig, Karl
  • Zlabinger, Gerhard J.
  • Hörl, Walter H.
  • Säemann, Marcus D.
ORCID
Venue
Journal of the American Society of Nephrology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2012-05
Volume
23
Issue
5
Pages
934-947
ISSN
1046-6673 (ISSN-L)
DOI
10.1681/asn.2011070668
PMC
PMC3338291
OpenAlex
W2139976637
Cited by
201
References
81
Citations by year
2026: 5 · 2025: 6 · 2024: 7 · 2023: 5 · 2022: 13 · 2021: 18 · 2020: 11 · 2019: 15 · 2018: 17 · 2017: 20 · 2016: 17 · 2015: 22 · 2014: 21 · 2013: 18 · 2012: 6
FWCI
16.92
Type
journal article
Language
en
Open access
Locations
  • Journal of the American Society of Nephrology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
  • Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Keywords
serum amyloid A, end-stage renal disease, HDL dysfunction, inflammation, inflammatory cytokines, TLR2, monocytes, HDL-associated proteins, surfactant protein B, apolipoprotein C-II, alpha1-microglobulin, HDL oxidation, chronic kidney disease, cardiovascular mortality
MeSH terms
Adult, Aged, Serum Amyloid A Protein, Female, Humans, Inflammation, Iron, Kidney Failure, Chronic, Lipoproteins, HDL, Male, Middle Aged, Oxidation-Reduction, Uremia, Pulmonary Surfactant-Associated Protein B, Proteomics

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