The TSC-mTOR Signaling Pathway Regulates the Innate Inflammatory Response

TOR signaling in growth and metabolism

Wullschleger, S., Loewith, R., & Hall, M. N. (2006) · Cell · doi:10.1016/j.cell.2006.01.016 · Cited by 5,787 · see citing works

Upstream and downstream of mTOR

Hay, N., & Sonenberg, N. (2004) · Genes & Development · doi:10.1101/gad.1212704 · Cited by 4,181 · see citing works

Interleukin-12 and the regulation of innate resistance and adaptive immunity

Trinchieri, G. (2003) · Nature reviews. Immunology · doi:10.1038/nri1001 · Cited by 3,933 · see citing works

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Inoki, K., Li, Y., Zhu, T., Wu, J., & Guan, K.-L. (2002) · Nature Cell Biology · doi:10.1038/ncb839 · Cited by 3,083 · see citing works

Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB

Sarbassov, D. D., Ali, S. M., Sengupta, S., Sheen, J.-H., Hsu, P. P., Bagley, A. F., Markhard, A. L., & Sabatini, D. M. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.03.029 · Cited by 2,659 · see citing works

Integrating cell-signalling pathways with NF-κB and IKK function

Perkins, N. D. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2083 · Cited by 2,350 · see citing works

Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor

Guba, M. O., von Breitenbuch, P., Steinbauer, M. G. M., Koehl, G. E., Flegel, S., Hornung, M., Bruns, C. J., Zuelke, C., Farkas, S. A., Anthuber, M., et al. (2002) · Nature Medicine · doi:10.1038/nm0202-128 · Cited by 1,739 · see citing works

MAP Kinases in the Immune Response

Dong, C., Davis, R. J., & Flavell, R. A. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.091301.131133 · Cited by 1,660 · see citing works

Immunosuppressive Drugs for Kidney Transplantation

Halloran, P. F. (2004) · New England Journal of Medicine · doi:10.1056/nejmra033540 · Cited by 1,557 · see citing works

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

Manning, B. D., Tee, A. R., Logsdon, M. N., Blenis, J., & Cantley, L. C. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00568-3 · Cited by 1,555 · see citing works

Stattic: a small-molecule inhibitor of STAT3 activation and dimerization

Schust, J., Sperl, B., Hollis, A., Mayer, T. U., & Berg, T. (2006) · Chemistry & Biology · doi:10.1016/j.chembiol.2006.09.018 · Cited by 1,105 · see citing works

Current development of mTOR inhibitors as anticancer agents

Faivre, S. J., Kroemer, G., & Raymond, É. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2062 · Cited by 998 · see citing works

Inhibition of Nuclear Translocation of Transcription Factor NF-κB by a Synthetic Peptide Containing a Cell Membrane-permeable Motif and Nuclear Localization Sequence

Lin, Y.-Z., Yao, S., Veach, R. A., Torgerson, T. R., & Hawiger, J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.24.14255 · Cited by 919 · see citing works

Human endothelial cells express CCR2 and respond to MCP-1: direct role of MCP-1 in angiogenesis and tumor progression

Salcedo, R., Ponce, M. L., Young, H. A., Wasserman, K., Ward, J. M., Kleinman, H. K., Oppenheim, J. J., & Murphy, W. J. (2000) · Blood · doi:10.1182/blood.v96.1.34 · Cited by 860 · see citing works

A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells.

Sekulić, A., Hudson, C. C., Homme, J. L., Yin, P., Otterness, D. M., Karnitz, L. M., & Abraham, R. T. (2000) · PubMed · Cited by 712 · see citing works

The evolution and genetics of innate immunity

Kimbrell, D., & Beutler, B. (2001) · Nature reviews genetics · doi:10.1038/35066006 · Cited by 679 · see citing works

Toll-like receptor 2–mediated NF-κB activation requires a Rac1-dependent pathway

Arbibe, L., Mira, J. P., Teusch, N. E., Kline, L., Guha, M., Mackman, N., Godowski, P. J., Ulevitch, R. J., & Knaus, U. G. (2000) · Nature Immunology · doi:10.1038/82797 · Cited by 664 · see citing works

IKKβ Suppression of TSC1 Links Inflammation and Tumor Angiogenesis via the mTOR Pathway

Lee, D., Kuo, H.-P., Chen, C., Hsu, J.-M., Chou, C., Wei, Y., Sun, H., Li, L., Ping, B., Huang, W., et al. (2007) · Cell · doi:10.1016/j.cell.2007.05.058 · Cited by 639 · see citing works

Expanding mTOR signaling

Yang, Q., & Guan, K. (2007) · Cell Research · doi:10.1038/cr.2007.64 · Cited by 540 · see citing works

PI3K-mediated negative feedback regulation of IL-12 production in DCs

Fukao, T., Tanabe, M., Terauchi, Y., Ota, T., Matsuda, S., Asano, T., Kadowaki, T., Takeuchi, T., & Koyasu, S. (2002) · Nature Immunology · doi:10.1038/ni825 · Cited by 529 · see citing works

A Critical Role for Stat3 Signaling in Immune Tolerance

Cheng, F., Wang, H.-W., Cuenca, A., Huang, M., Ghansah, T., Brayer, J., Kerr, W. G., Takeda, K., Akira, S., Schoenberger, S. P., et al. (2003) · Immunity · doi:10.1016/s1074-7613(03)00232-2 · Cited by 377 · see citing works

Translational control of the innate immune response through IRF-7

Colina, R., Costa‐Mattioli, M., Dowling, R. J. O., Jaramillo, M., Tai, L., Breitbach, C. J., Martineau, Y., Larsson, O. S., Rong, L., Svitkin, Y. V., et al. (2008) · Nature · doi:10.1038/nature06730 · Cited by 316 · see citing works

Critical Roles of Myeloid Differentiation Factor 88-Dependent Proinflammatory Cytokine Release in Early Phase Clearance of Listeria monocytogenes in Mice1

Seki, E., Tsutsui, H., Tsuji, N., Hayashi, N., Adachi, K., Nakano, H., Futatsugi-Yumikura, S., Takeuchi, O., Hoshino, K., Akira, S., et al. (2002) · Journal of Immunology · doi:10.4049/jimmunol.169.7.3863 · Cited by 307 · see citing works

Neutralization of IL-12 decreases resistance to Listeria in SCID and C.B-17 mice. Reversal by IFN-gamma.

Tripp, C. S., Gately, M. K., Hakimi, J., Ling, P., & Unanue, E. R. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.4.1883 · Cited by 296 · see citing works

Rapamycins: Mechanisms of Action and Cellular Resistance

Huang, S., Bjornsti, M., & Houghton, P. J. (2003) · Cancer Biology & Therapy · doi:10.4161/cbt.2.3.360 · Cited by 288 · see citing works

Role of the Phosphatidylinositol 3 Kinase-Akt Pathway in the Regulation of IL-10 and IL-12 by Porphyromonas gingivalis Lipopolysaccharide

Martin, M., Schifferle, R. E., Cuesta, N., Vogel, S. N., Katz, J., & Michalek, S. M. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.2.717 · Cited by 259 · see citing works

Rapamycin-Treated, Alloantigen-Pulsed Host Dendritic Cells Induce Ag-Specific T Cell Regulation and Prolong Graft Survival

Taner, T., Hackstein, H., Wang, Z., Morelli, A. E., & Thomson, A. W. (2005) · American Journal of Transplantation · doi:10.1046/j.1600-6143.2004.00673.x · Cited by 250 · see citing works

Role of Stat3 in Lipopolysaccharide-Induced IL-10 Gene Expression

Benkhart, E. M., Siedlar, M., Wedel, A., Werner, T., & Ziegler-Heitbrock, H. W. L. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.3.1612 · Cited by 249 · see citing works

Tamm-Horsfall glycoprotein links innate immune cell activation with adaptive immunity via a Toll-like receptor-4–dependent mechanism

Säemann, M. D., Weichhart, T., Zeyda, M., Staffler, G., Schunn, M., Stuhlmeier, K. M., Sobanov, Y., Stulnig, T. M., Akira, S., von Gabain, A., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci22720 · Cited by 242 · see citing works

Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: rapamycin triggers dephosphorylation and delocalization of the mTORC2 components rictor and sin1

Rosner, M., & Hengstschläger, M. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn192 · Cited by 233 · see citing works

Cutting Edge: Involvement of the Type I IFN Production and Signaling Pathway in Lipopolysaccharide-Induced IL-10 Production

Chang, E. Y., Guo, B., Doyle, S. E., & Cheng, G. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.11.6705 · Cited by 228 · see citing works

Both innate and acquired immunity to Listeria monocytogenes infection are increased in IL-10-deficient mice

Dai, W. J., Köhler, G., & Brombacher, F. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.5.2259 · Cited by 198 · see citing works

p53- and Mdm2-Independent Repression of NF-κB Transactivation by the ARF Tumor Suppressor

Rocha, S., Campbell, K. J., & Perkins, N. D. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00223-5 · Cited by 189 · see citing works

Rapamycin impairs antigen uptake of human dendritic cells1

Monti, P., Mercalli, A., Leone, B. E., Valerio, D. C., Allavena, P., & Piemonti, L. (2003) · Transplantation · doi:10.1097/00007890-200301150-00025 · Cited by 165 · see citing works

A novel population of Gr-1+-activated macrophages induced during acute toxoplasmosis

Mordue, D. G., & Sibley, L. D. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0403164 · Cited by 163 · see citing works

Signal Transducer and Activator of Transcription-3 (STAT3) Is Constitutively Activated in Normal, Self-renewing B-1 Cells but Only Inducibly Expressed in Conventional B Lymphocytes

Karras, J., Wang, Z.-H., Huo, L., Howard, R., Frank, D., & Rothstein, T. (1997) · Journal of Experimental Medicine · doi:10.1084/jem.185.6.1035 · Cited by 160 · see citing works

Interstitial Pneumonitis Associated with Sirolimus Therapy in Renal-Transplant Recipients

Morélon, E., Stern, M., & Kreis, H. (2000) · New England Journal of Medicine · doi:10.1056/nejm200007203430317 · Cited by 153 · see citing works

IFN-α Induces the Human IL-10 Gene by Recruiting Both IFN Regulatory Factor 1 and Stat3

Ziegler-Heitbrock, L., Lötzerich, M., Schaefer, A. E., Werner, T., Frankenberger, M., & Benkhart, E. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.1.285 · Cited by 146 · see citing works

PTEN Blocks Tumor Necrosis Factor-induced NF-κB-dependent Transcription by Inhibiting the Transactivation Potential of the p65 Subunit

Mayo, M. W., Madrid, L. V., Westerheide, S. D., Jones, D. R., Yuan, X., Baldwin, A. S., & Whang, Y. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108670200 · Cited by 122 · see citing works

Essential role of tuberous sclerosis genes TSC1 and TSC2 in NF-κB activation and cell survival

Ghosh, S., Tergaonkar, V., Rothlin, C. V., Correa, R. G., Bottero, V., Bist, P., Verma, I. M., & Hunter, T. R. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.08.007 · Cited by 114 · see citing works

Rapamycin-associated post-transplantation glomerulonephritis and its remission after reintroduction of calcineurin-inhibitor therapy

Dittrich, E., Schmaldienst, S., Soleiman, A., et al. (2004) · Transplant International · doi:10.1007/s00147-004-0700-0 · Cited by 112 · see citing works

Rapamycin-associated post-transplantation glomerulonephritis and its remission after reintroduction of calcineurin-inhibitor therapy

Dittrich, E., Schmaldienst, S., Soleiman, A., et al. (2004) · Transplant International · doi:10.1111/j.1432-2277.2004.tb00431.x · Cited by 111 · see citing works

Post-Transplantation Proteinuria and Sirolimus

Izzedine, H., Brochériou, I., & Françès, C. (2005) · New England Journal of Medicine · doi:10.1056/nejm200511103531922 · Cited by 110 · see citing works

Intracellular network of phosphatidylinositol 3-kinase, mammalian target of the rapamycin/70 kDa ribosomal S6 kinase 1, and mitogen-activated protein kinases pathways for regulating mycobacteria-induced IL-23 expression in human macrophages

Yang, C., Song, C., Lee, J., Jung, S.-B., Oh, J.-H., Park, J., Kim, H., Park, J., Paik, T.-H., & Jo, E. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00699.x · Cited by 108 · see citing works

Interstitial Pneumonitis Associated with Sirolimus Therapy in Renal-Transplant Recipients

Singer, S. J., Tiernan, R., & Sullivan, E. J. (2000) · New England Journal of Medicine · doi:10.1056/nejm200012143432417 · Cited by 105 · see citing works

Anemia after Late Introduction of Sirolimus May Correlate with Biochemical Evidence of a Chronic Inflammatory State

Thaunat, O., Beaumont, C., Chatenoud, L., Lechaton, S., Mamzer, M., Varet, B. R., Kreis, H., & Morélon, E. (2005) · Transplantation · doi:10.1097/01.tp.0000179106.07382.6a · Cited by 90 · see citing works

Novel Functions of Tyrosine Kinase 2 in the Antiviral Defense against Murine Cytomegalovirus

Strobl, B., Bubić, I., Bruns, U., Steinborn, R., Lajko, R., Kolbe, T., Karaghiosoff, M., Kalinke, U., Jonjić, S., & Müller, M. M. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.6.4000 · Cited by 63 · see citing works

Efficacy of Sirolimus in Treating Tuberous Sclerosis and Lymphangioleiomyomatosis

Paul, E., & Thiele, E. A. (2008) · New England Journal of Medicine · doi:10.1056/nejme0707153 · Cited by 56 · see citing works

Sirolimus approved with renal transplant indication

Miller, J. L. (1999) · American Journal of Health-System Pharmacy · doi:10.1093/ajhp/56.21.2177 · Cited by 44 · see citing works

Macrophage activation and polarization: nomenclature and experimental guidelines

Murray, P. J., Allen, J. E., Biswas, S. K., Fisher, E. A., Gilroy, D. W., Goerdt, S., Gordon, S., Hamilton, J. A., Ivashkiv, L. B., Lawrence, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.008 · Cited by 6,337 · see citing works

mTOR regulates memory CD8 T-cell differentiation

Araki, K., Turner, A. P., Shaffer, V. O., Gangappa, S., Keller, S. A., Bachmann, M. F., Larsen, C. P., & Ahmed, R. (2009) · Nature · doi:10.1038/nature08155 · Cited by 1,575 · see citing works

Immune system to brain signaling: Neuropsychopharmacological implications

Capuron, L., & Miller, A. H. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.01.014 · Cited by 1,195 · see citing works

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

Laberge, R.-M., Sun, Y., Orjalo, A. V., Patil, C. K., Freund, A., Zhou, L., Curran, S. C., Davalos, A. R., Wilson-Edell, K. A., Liu, S., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3195 · Cited by 1,160 · see citing works

Regulation of Immune Responses by mTOR

Powell, J. D., Pollizzi, K. N., Heikamp, E. B., & Horton, M. R. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075024 · Cited by 836 · see citing works

mTOR Signaling in Disease

Dazert, E., & Hall, M. N. (2011) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2011.09.003 · Cited by 460 · see citing works

<scp>mTOR</scp> , metabolism, and the regulation of T‐cell differentiation and function

Waickman, A. T., & Powell, J. D. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01152.x · Cited by 420 · see citing works

SARS-CoV-2, COVID-19 and the aging immune system

Bartleson, J. M., Radenkovic, D., Covarrubias, A. J., Furman, D., Winer, D. A., & Verdin, E. (2021) · Nature Aging · doi:10.1038/s43587-021-00114-7 · Cited by 359 · see citing works

Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation

Su, X., Yu, Y., Zhong, Y., Giannopoulou, E. G., Hu, X., Liu, H., Cross, J. R., Rätsch, G., Rice, C. M., & Ivashkiv, L. B. (2015) · Nature Immunology · doi:10.1038/ni.3205 · Cited by 298 · see citing works

Mechanical stiffness controls dendritic cell metabolism and function

Chakraborty, M., Chu, K., Shrestha, A., Revelo, X. S., Zhang, X., Gold, M. J., Khan, S., Lee, M., Huang, C., Akbari, M., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2020.108609 · Cited by 258 · see citing works

Roles of mTOR complexes in the kidney: implications for renal disease and transplantation

Fantus, D., Rogers, N. M., Grahammer, F., Huber, T. B., & Thomson, A. W. (2016) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.108 · Cited by 208 · see citing works

Serum Amyloid A in Uremic HDL Promotes Inflammation

Weichhart, T., Kopecky, C., Kubicek, M., Haidinger, M., Döller, D., Katholnig, K., Suarna, C., Eller, P., Tölle, M., Gerner, C., et al. (2012) · Journal of the American Society of Nephrology · doi:10.1681/asn.2011070668 · Cited by 201 · see citing works

The immunobiology of mTOR in autoimmunity

Suto, T., & Karonitsch, T. (2020) · Journal of Autoimmunity · doi:10.1016/j.jaut.2019.102373 · Cited by 149 · see citing works

Intersection of mTOR and STAT signaling in immunity

Saleiro, D., & Platanias, L. C. (2015) · Trends in Immunology · doi:10.1016/j.it.2014.10.006 · Cited by 142 · see citing works

Inhibition of mTOR blocks the anti-inflammatory effects of glucocorticoids in myeloid immune cells

Weichhart, T., Haidinger, M., Katholnig, K., Kopecky, C., Poglitsch, M., Lassnig, C., Rosner, M., Zlabinger, G. J., Hengstschläger, M., Müller, M., et al. (2011) · Blood · doi:10.1182/blood-2010-09-310888 · Cited by 141 · see citing works

mTOR regulates metabolic adaptation of APCs in the lung and controls the outcome of allergic inflammation

Sinclair, C., Bommakanti, G., Gardinassi, L., Loebbermann, J., Johnson, M. J., Hakimpour, P., Hagan, T., Benitez, L., Todor, A., Machiah, D., et al. (2017) · Science · doi:10.1126/science.aaj2155 · Cited by 126 · see citing works

Monocyte and macrophage biology: an overview

Rees, A. J. (2010) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2010.03.002 · Cited by 84 · see citing works

Regulation of Inflammatory Response by 3-Methyladenine Involves the Coordinative Actions on Akt and Glycogen Synthase Kinase 3β Rather than Autophagy

Lin, Y.-C., Kuo, H.-C., Wang, J.-S., & Lin, W.-W. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102739 · Cited by 46 · see citing works

mTORC2 deficiency alters the metabolic profile of conventional dendritic cells

Watson, A. R., Dai, H., Zheng, Y., Nakano, R., Giannou, A. D., Menk, A. V., Stolz, D. B., Delgoffe, G. M., & Thomson, A. W. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01451 · Cited by 15 · see citing works

A Novel Quinoline Based Second-generation mTOR Inhibitor that Induces Apoptosis and Disrupts PI3K-Akt-mTOR Signaling in Human Leukemia HL-60 Cells

Kumar, S. G., Guru, S. K., Venkateswarlu, V., et al. (2015) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520615666150402093558 · Cited by 11 · see citing works

Akt-dependent and -independent mechanisms of mTOR regulation in cancer

Memmott, R. M., & Dennis, P. A. (2009) · Cellular Signalling · doi:10.1016/j.cellsig.2009.01.004 · Cited by 382 · see citing works

mTOR/p70S6K signaling pathway constitutively activated in esophageal squamous cell carcinona cell lines and inhibition of the pathway by rapamycin and siRNA against mTOR

Hou, G., Xu, P., Xue, Y., et al. (2007) · Cancer Research

An activated mTOR/p70S6K signaling pathway in esophageal squamous cell carcinoma cell lines and inhibition of the pathway by rapamycin and siRNA against mTOR

Hou, G., Xue, L., Lu, Z., Fan, T., Tian, F., & Xue, Y. (2007) · Cancer Letters · doi:10.1016/j.canlet.2007.01.026 · Cited by 133 · see citing works

A PI3K/PKB-Independent Activation of mTOR Signaling is Sufficient to Induce Skeletal Muscle Hypertrophy

Goodman, C. A., Miu, M. H., Frey, J. W., et al. (2010) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000389388.95428.31 · Cited by 1 · see citing works