The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
A Potential Role for Mechanical Forces in the Detachment of Podocytes and the Progression of CKD
Open accessAbstract
Loss of podocytes underlies progression of CKD. Detachment of podocytes from the glomerular basement membrane (GBM) rather than apoptosis or necrosis seems to be the major mechanism of podocyte loss. Such detachment of viable podocytes may be caused by increased mechanical distending and shear forces and/or impaired adhesion to the GBM. This review considers the mechanical challenges that may lead to podocyte loss by detachment from the GBM under physiologic and pathophysiologic conditions, including glomerular hypertension, hyperfiltration, hypertrophy, and outflow of filtrate from subpodocyte spaces. Furthermore, we detail the cellular mechanisms by which podocytes respond to these challenges, discuss the protective effects of angiotensin blockade, and note the questions that must be addressed to better understand the relationship between podocyte detachment and progression of CKD.
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Cites
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Podocyte loss and progressive glomerular injury in type II diabetes.
Pagtalunan, M. E., Miller, P. L., Jumping-Eagle, S., Nelson, R. G., Myers, B. D., Rennke, H. G., Coplon, N. S., Sun, L., & Meyer, T. W. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119163 · Cited by 1,088
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Anderson, S., Meyer, T. W., Rennke, H. G., & Brenner, B. M. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112013 · Cited by 932
Properties of the Glomerular Barrier and Mechanisms of Proteinuria
Haraldsson, B., Nyström, J., & Deen, W. M. (2008) · Physiological Reviews · doi:10.1152/physrev.00055.2006 · Cited by 909
The hyperfiltration theory: A paradigm shift in nephrology
Brenner, B. M., Lawler, E. V., & Mackenzie, H. S. (1996) · Kidney International · doi:10.1038/ki.1996.265 · Cited by 868
Hostetter, T. H., Rennke, H. G., & Brenner, B. M. (1982) · The American Journal of Medicine · doi:10.1016/0002-9343(82)90490-9 · Cited by 796
Wharram, B. L., Goyal, M., Wiggins, J. E., Sanden, S. K., Hussain, S., Filipiak, W. E., Saunders, T. L., Dysko, R. C., Kohno, K., Holzman, L. B., et al. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005010055 · Cited by 737
Glomerular hyperfiltration: definitions, mechanisms and clinical implications
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Nephron adaptation to renal injury or ablation
Brenner, B. M. (1985) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1985.249.3.f324 · Cited by 641
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Cited by
Obesity-related glomerulopathy: clinical and pathologic characteristics and pathogenesis
D'Agati, V. D., Chagnac, A., de Vries, A. P. J., Levi, M., Porrini, E., Herman-Edelstein, M., & Praga, M. (2016) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.75 · Cited by 716
Focal Segmental Glomerulosclerosis
Rosenberg, A. Z., & Kopp, J. B. (2017) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.05960616 · Cited by 562
The cell biology of renal filtration
Scott, R. P., & Quaggin, S. E. (2015) · Journal of Cell Biology · doi:10.1083/jcb.201410017 · Cited by 372
Molecular pathways that drive diabetic kidney disease
Mohandes, S., Doke, T., Hu, H., Mukhi, D., Dhillon, P., & Susztak, K. (2023) · Journal of Clinical Investigation · doi:10.1172/jci165654 · Cited by 341
Rinschen, M. M., Gödel, M., Grahammer, F., Zschiedrich, S., Helmstädter, M., Kretz, O., Zarei, M., Braun, D. A., Dittrich, S., Pahmeyer, C., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.04.059 · Cited by 105
“This is consistent with observations that podocytes strongly react to other mechanical cues, such as hydrostatic pressure (Kriz and Lemley, 2015), stretch (Durvasula et al.”
Result
Metadata
- Authors
- Kriz, W., & Lemley, K. V.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2015-02
- Volume
- 26
- Issue
- 2
- Pages
- 258-269
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2166080653
- Cited by
- 286
- References
- 70
- FWCI
- 15.18
- Type
- journal article
- Language
- en
- Open access
- green
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- Kriz, W., & Lemley, K. V. (2015). A Potential Role for Mechanical Forces in the Detachment of Podocytes and the Progression of CKD. Journal of the American Society of Nephrology. https://doi.org/10.1681/asn.2014030278
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
