Impact of treatment with metformin on adipokines in patients with polycystic ovary syndrome
Abstract
BACKGROUND: Adipose tissue synthesizes various adipokines such as resistin, adiponectin and visfatin, which have an effect on insulin resistance. This study was designed to show the effect of metformin, one of the most important drugs used to reduce insulin resistance in patients with polycystic ovary syndrome (PCOS), on these adipokines. METHODS: The study group consisted of 24 women with PCOS and 25 healthy, age- and weight-matched, normally menstruating women. Hormone and lipid profiles, visfatin, adiponectin and resistin were measured in all cases, before and after metformin treatment. RESULTS: Serum visfatin levels were found to be significantly higher in patients with PCOS, compared to controls. Following metformin treatment, a significant decrease was observed in visfatin levels compared to the baseline. A positive correlation was found between serum visfatin levels and BMI, waist circumference, HOMA, insulin and triglyceride levels. No statistically significant difference was observed in terms of serum adiponectin levels in women with PCOS before and after treatment, or in healthy controls. Serum resistin levels were significantly reduced by metformin treatment. CONCLUSION: These findings suggest that visfatin may be related to the obesity and insulin resistance that is frequently encountered in patients with PCOS. A reduction in serum visfatin and resistin levels was shown with metformin treatment, in patients with PCOS.
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Metformin might alleviate symptoms and treat PCOS by correcting abnormal levels of certain adipokines, such as resistin, visfatin, irisin, and chemerin.
“Metformin might alleviate the symptoms and treat PCOS by correcting the abnormal levels of certain adipokines, such as resistin, visfatin, irisin, and chemerin levels (18, 52–54).”
From Circulating Adipokine Levels in Nonobese Women with Polycystic Ovary Syndrome and in Nonobese Control Women: A Systematic Review and Meta-Analysis (2021) · cites this paper as [52]
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- Authors
- Tarkun
- Venue
- PubMed
- Publisher
- National Institutes of Health
- Published
- 2010-12-01
- Volume
- 21
- Issue
- 4
- Pages
- 272-7
- OpenAlex
- W1732096533
- Cited by
- 28
- References
- 34
- Citations by year
- 2023: 3 · 2022: 5 · 2021: 4 · 2019: 1 · 2017: 2 · 2015: 2 · 2014: 6 · 2013: 3 · 2012: 2
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- PubMed (publishedVersion)
- Kocaeli Üniversitesi - AVESİS (submittedVersion)
- PubMed
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- metformin, polycystic ovary syndrome, adipokines, visfatin, resistin, adiponectin, insulin resistance, obesity, HOMA-IR, triglycerides, body mass index
- MeSH terms
- Adult, Blood Chemical Analysis, Female, Humans, Hypoglycemic Agents, Metformin, Polycystic Ovary Syndrome, Adipokines, Young Adult
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