Effect of metformin on serum visfatin levels in patients with polycystic ovary syndrome
Open accessAbstract
Objective To evaluate serum visfatin levels and to determine the effects of metformin treatment on visfatin levels in patients with polycystic ovary syndrome (PCOS).Design Cross-sectional study.Setting University hospital.Patient(s) Nineteen patients with PCOS and 21 controls.Intervention(s) Metformin was given to patients with PCOS, and serum visfatin levels were measured before and after treatment.Main outcome measure(s) Glucose, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, DHEAS, total T, insulin, homeostatic model assessment for insulin resistance (HOMA-IR), and visfatin levels were measured.Result(s) Serum visfatin levels were significantly higher in women with PCOS than in controls. Visfatin could differentiate between women with and without increased diabetogenic risk at a cut-off value of 19.24 ng/mL, with a sensitivity of 93.3% and a specificity of 84%. In bivariate analysis of subjects, T, insulin, and waist circumference were significantly and positively correlated with visfatin. Treatment resulted in a significant decrease in body mass index and a decrease in visfatin concentration. After therapy, statistically significant decreases in HOMA-IR, fasting insulin, free T, and DHEAS concentrations were observed for the PCOS group.Conclusion(s) Circulating visfatin levels were higher in patients with PCOS than healthy controls, and metformin treatment significantly reduced circulating visfatin concentrations after 3 months of therapy.
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Metformin might alleviate symptoms and treat PCOS by correcting abnormal levels of certain adipokines, such as resistin, visfatin, irisin, and chemerin.
“Metformin might alleviate the symptoms and treat PCOS by correcting the abnormal levels of certain adipokines, such as resistin, visfatin, irisin, and chemerin levels (18, 52–54).”
From Circulating Adipokine Levels in Nonobese Women with Polycystic Ovary Syndrome and in Nonobese Control Women: A Systematic Review and Meta-Analysis (2021) · cites this paper as [53]
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- Authors
- Ozkaya, M., Cakal, E., Ustun, Y., & Engin-Ustun, Y.
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 93
- Issue
- 3
- Pages
- 880-884
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2165184461
- Cited by
- 67
- References
- 23
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 6 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 2 · 2015: 6 · 2014: 8 · 2013: 5 · 2012: 6
- FWCI
- 4.25
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- metformin, visfatin, polycystic ovary syndrome, insulin resistance, HOMA-IR, insulin, type 2 diabetes risk, body mass index, free testosterone, waist circumference
- MeSH terms
- Adult, Blood Glucose, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Female, Homeostasis, Humans, Hypoglycemic Agents, Insulin Resistance, Lipids, Metformin, Polycystic Ovary Syndrome, Risk Factors, Sensitivity and Specificity, Body Mass Index, Cytokines, Nicotinamide Phosphoribosyltransferase, Waist Circumference, Young Adult
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