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Cognitive impairment in epilepsy: the role of network abnormalities
Open accessAbstract
The challenges to individuals with epilepsy extend far beyond the seizures. Co‐morbidities in epilepsy are very common and are often more problematic to individuals than the seizures themselves. In this review, the pathophysiological mechanisms of cognitive impairment are discussed. While aetiology of the epilepsy has a significant influence on cognition, there is increasing evidence that prolonged or recurrent seizures can cause or exacerbate cognitive impairment. Alterations in signalling pathways and neuronal network function play a major role in both the pathophysiology of epilepsy and the epilepsy comorbidities. However, the biological underpinnings of cognitive impairment can be distinct from the pathophysiological processes that cause seizures.
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“Epilepsy, specifically childhood frontal lobe epilepsy (FLE) has various clinical outcomes but most often resulting in multi-cognitive symptoms [384–387].”
From Development of prefrontal cortex (2022) · cites this paper as [385]
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“Though cognitive deficits can independently occur in seizure disorders as a direct result of disease etiology, such as trauma, epileptic activity contributes to, and exacerbates cognitive decline (Holmes, 2015).”
From Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms (2022) · cites this paper as Holmes, 2015
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Cites
mTOR Signaling in Growth Control and Disease
Laplante, M., & Sabatini, D. M. (2012) · Cell · doi:10.1016/j.cell.2012.03.017 · Cited by 8,509
Neuronal Oscillations in Cortical Networks
Buzsáki, G., & Draguhn, A. (2004) · Science · doi:10.1126/science.1099745 · Cited by 6,576
The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat
O'Keefe, J., & Dostrovsky, J. (1971) · Brain Research · doi:10.1016/0006-8993(71)90358-1 · Cited by 6,151
A mechanism for cognitive dynamics: neuronal communication through neuronal coherence.
Fries, P. (2005) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2005.08.011 · Cited by 4,284
Theta oscillations in the hippocampus
Buzsáki, G. (2002) · Neuron · doi:10.1016/s0896-6273(02)00586-x · Cited by 3,332
Reactivation of hippocampal ensemble memories during sleep
Wilson, M. A., & McNaughton, B. L. (1994) · Science · doi:10.1126/science.8036517 · Cited by 3,118
Phase relationship between hippocampal place units and the EEG theta rhythm
O'Keefe, J. M., & Recce, M. L. (1993) · Hippocampus · doi:10.1002/hipo.450030307 · Cited by 2,643
Neocortical excitation/inhibition balance in information processing and social dysfunction
Yizhar, O., Fenno, L. E., Prigge, M., Schneider, F., Davidson, T. J., O’Shea, D. J., Sohal, V. S., Goshen, I., Finkelstein, J., Paz, J. T., et al. (2011) · Nature · doi:10.1038/nature10360 · Cited by 2,454
Reverse replay of behavioural sequences in hippocampal place cells during the awake state
Foster, D. J., & Wilson, M. A. (2006) · Nature · doi:10.1038/nature04587 · Cited by 1,727
Modulation of Neuronal Interactions Through Neuronal Synchronization
Womelsdorf, T., Schoffelen, J.-M., Oostenveld, R., Singer, W., Desimone, R., Engel, A. K., & Fries, P. (2007) · Science · doi:10.1126/science.1139597 · Cited by 1,367
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Items 301–331 of 331
Okano, Y., Kase, Y., Suematsu, Y., Nakamura, M., & Okano, H. (2024) · Figshare · doi:10.6084/m9.figshare.25397529
Influence of Neurotransmitters Disruption on the Deterioration of Cognitive Function
Gupta, P., Yadav, P., Shrivastava, S., & Soni, R. K. (2025) · IGI Global eBooks · doi:10.4018/979-8-3373-4627-4.ch001
Alhwaiti, M. (2025) · Applied Neuropsychology Adult · doi:10.1080/23279095.2025.2605300
Heruye, S., Matthews, S. A., Iyer, S. H., Deodhar, M., Warren, T. J., West, P. J., Simeone, K. A., & Simeone, T. A. (2026) · Antioxidants · doi:10.3390/antiox15020259 · Cited by 1
Role of microtubule affinity‐regulating kinases in epilepsy: A novel therapeutic strategy
Xu, M., Shi, Y., Mu, X., Su, C., Wei, P., Wang, Q., Zhang, Y., Ji, S., Fu, C., Tian, J., et al. (2026) · British Journal of Pharmacology · doi:10.1111/bph.70354
Reecher, H. M., Park, S. E., Singh, A., Kim, I., Lew, S. M., & Koop, J. I. (2026) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2026.110966
Çelebi, U., Çınar, B. P., Ceylan, N., Yiğit, P., Boz, B. D., Bünül, S. D., Mantar, A., & Atasoy, H. T. (2026) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2026.110958
Reitsma, F. J., Verburgt, E., Schellekens, M. M. I., Hilkens, N. A., Verhoeven, J. I., van Alebeek, M. E., Brouwers, P. J. A. M., Arntz, R. M., van Dijk, G. W., Gons, R. A. R., et al. (2026) · Epilepsia · doi:10.1002/epi.70200
Jing, L., Cui, Z., Luo, Y., Zhang, H., Liu, Y., & Yi, Y. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05801-3
From gastric to neuroprotection: pantoprazole mitigates epilepsy via TrkB/BDNF and KCC2 modulation
Vishwapriya, A. K., Verma, K., Sharma, G., Sindhu, N., Paliwal, S., Jain, S., Dwivedi, J., Paliwal, S., & Sharma, S. K. (2026) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-026-05204-0
Forensic Neuroscience, Epilepsy, and Violence
Fabian, J. M. (2026) · doi:10.1002/9781118832202.ch18
Temporal networks : from network theory to brain science
Pedreschi, N. (2021) · theses.fr (ABES) · doi:10.70675/2c6a8512z4f2fz4c59z84b5z21ce06ccbcd2
Woodard, G. E. (2026) · Neurochemistry International · doi:10.1016/j.neuint.2026.106161
Case Report: Early surgical intervention for epilepsy with mild MOGHE: timing and clinical efficacy
Sun, Y., Chen, L., Jin, M. H., Yang, F., Du, Y., Fang, J., Li, B., Sun, Z., Wang, L., Cheng, Z., et al. (2026) · Frontiers in Pediatrics · doi:10.3389/fped.2026.1790096
High-frequency oscillations and sleep spindles in epilepsy: from mechanisms to modeling
Zhao, K., Wu, M., Zhao, J., Teng, Y., Sun, Z. X., & Sun, Y. (2026) · Frontiers in Neurology · doi:10.3389/fneur.2026.1779207
McCreesh, M., Nozari, E., & Cortés, J. (2026) · IEEE Control Systems · doi:10.1109/mcs.2026.3664673 · Cited by 1
Răducu, L., Georgescu, D. E., Balcangiu‐Stroescu, A.-E., Chiperi, L. V., Văcăroiu, I. A., Bălan, D.-G., Georgescu, M. T., Mihai, D. A., Ignat, L. A., & Tipa, R. O. (2024) · OSF Preprints (OSF Preprints)
Çevreli, B., Özcan, Ö. Ö., Gerger, B. B., Demirhan, E. E., & Erguzel, T. T. (2026) · Research in Autism · doi:10.1016/j.reia.2026.202946
Epilepsy associated cognitive dysfunction and addiction: Possible mechanisms and clinical challenges
Anshul, Kaur, R., & Singh, S. (2026) · Physiology & Behavior · doi:10.1016/j.physbeh.2026.115421
Tomaiuolo, F., Vicario, C. M., Cardile, D., Campana, S., Calabrò, R. S., Corallo, F., & Labate, A. (2026) · Neurological Sciences · doi:10.1007/s10072-026-09174-2
Abdelazeem, I. M., Elmongui, A., Mustafa, W., Mashaly, M. E.-S., Elmokadem, A. H., & Tharwat, N. (2026) · The Egyptian Journal of Radiology and Nuclear Medicine · doi:10.1186/s43055-026-01800-5
Kubur, Ç. Ç., Özyurt, B. C., Bılaç, Ö., Orak, S. A., Atasever, A. K., & Polat, M. (2026) · Applied Neuropsychology Child · doi:10.1080/21622965.2026.2703179
Cano‐Villagrasa, A., Viqueira-Gutiérrez, L., Hoyos, S., & García-Rubio, M. J. (2026) · International Journal of Developmental Disabilities · doi:10.1080/20473869.2026.2699868
Walube, B. H., Namata, T. T., Wegoye, E., Rujumba, J., Lam, S. K., & Sebunya, R. K. (2026) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2026.07.031
Shakeel, W., Saghir, K. A., Ashraf, W., Alqarni, S. A., Anjum, S. M. M., Hannan, F., Alqahtani, F., & Imran, I. (2026) · Neurochemical Research · doi:10.1007/s11064-026-04859-8
Fadaie, F., Caldairou, B., Bernhardt, B. C., Bernasconi, A., & Bernasconi, N. (2026) · Epilepsia · doi:10.1002/epi.70470
Meron, D., Levinsky, Y., Prendes, M., Brosh, I., Freiman, M., & Freifeld, L. (2026) · Brain Communications · doi:10.1093/braincomms/fcag323
Meghana, V., & Angothu, H. (2026) · Journal of Psychiatry Spectrum · doi:10.4103/jopsys.jopsys_7_26
Common Data Elements for Preclinical High-Frequency Oscillations in Epilepsy
Wang, Z., Guo, J., & Lisgaras, C. P. (2026) · Epiliepsy currents/Epilepsy currents · doi:10.1177/15357597261491953
Metadata
- Authors
- Holmes, G. L.
- Affiliations
- University of Vermont (US)
- Corresponding author
- Holmes, Gregory L
- ORCID
- Holmes, Gregory L
- Venue
- Epileptic Disorders
- Publisher
- Wiley
- Published
- 2015-06
- Volume
- 17
- Issue
- 2
- Pages
- 101-116
- ISSN
- 1294-9361 (ISSN-L)
- 1950-6945
- PMC
- PMC5410366
- OpenAlex
- W1606616855
- Cited by
- 334
- References
- 89
- Citations by year
- 2026: 32 · 2025: 37 · 2024: 48 · 2023: 28 · 2022: 52 · 2021: 43 · 2020: 42 · 2019: 23 · 2018: 8 · 2017: 7 · 2016: 13 · 2015: 1
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Epileptic Disorders (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS073083, NS074450, NS073083, R01NS078279, R01NS074450)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- cognitive impairment, epilepsy, epilepsy comorbidity, epilepsy pathophysiology, recurrent seizures, signaling pathways
- MeSH terms
- Animals, Cognition Disorders, Epilepsy, Humans, Nerve Net, Brain Waves
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