Cited by 334Epilepsy research and treatmentPharmacological Effects and Toxicity StudiesNeural dynamics and brain function

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Cognitive impairment in epilepsy: the role of network abnormalities

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Holmes, Gregory L·2015·Epileptic Disorders

DOI 10.1684/epd.2015.0739PMC PMC5410366

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Abstract

The challenges to individuals with epilepsy extend far beyond the seizures. Co‐morbidities in epilepsy are very common and are often more problematic to individuals than the seizures themselves. In this review, the pathophysiological mechanisms of cognitive impairment are discussed. While aetiology of the epilepsy has a significant influence on cognition, there is increasing evidence that prolonged or recurrent seizures can cause or exacerbate cognitive impairment. Alterations in signalling pathways and neuronal network function play a major role in both the pathophysiology of epilepsy and the epilepsy comorbidities. However, the biological underpinnings of cognitive impairment can be distinct from the pathophysiological processes that cause seizures.

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Authors: Holmes, G. L.
Affiliations: University of Vermont (US)
Corresponding author: Holmes, Gregory L
ORCID: Holmes, Gregory L
Venue: Epileptic Disorders
Publisher: Wiley
Published: 2015-06
Volume: 17
Issue: 2
Pages: 101-116
ISSN: 1294-9361 (ISSN-L)
1950-6945
DOI: 10.1684/epd.2015.0739
PMC: PMC5410366
OpenAlex: W1606616855
Cited by: 334
References: 89
Citations by year: 2026: 32 · 2025: 37 · 2024: 48 · 2023: 28 · 2022: 52 · 2021: 43 · 2020: 42 · 2019: 23 · 2018: 8 · 2017: 7 · 2016: 13 · 2015: 1
FWCI: 1.33
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 24 d)
Locations: Epileptic Disorders (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Neurological Disorders and Stroke (R01NS073083, NS074450, NS073083, R01NS078279, R01NS074450)
Topics: Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: cognitive impairment, epilepsy, epilepsy comorbidity, epilepsy pathophysiology, recurrent seizures, signaling pathways
MeSH terms: Animals, Cognition Disorders, Epilepsy, Humans, Nerve Net, Brain Waves

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Cognitive impairment in epilepsy: the role of network abnormalities

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