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Cognitive impairment in epilepsy: the role of network abnormalities
Open accessAbstract
The challenges to individuals with epilepsy extend far beyond the seizures. Co‐morbidities in epilepsy are very common and are often more problematic to individuals than the seizures themselves. In this review, the pathophysiological mechanisms of cognitive impairment are discussed. While aetiology of the epilepsy has a significant influence on cognition, there is increasing evidence that prolonged or recurrent seizures can cause or exacerbate cognitive impairment. Alterations in signalling pathways and neuronal network function play a major role in both the pathophysiology of epilepsy and the epilepsy comorbidities. However, the biological underpinnings of cognitive impairment can be distinct from the pathophysiological processes that cause seizures.
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“Epilepsy, specifically childhood frontal lobe epilepsy (FLE) has various clinical outcomes but most often resulting in multi-cognitive symptoms [384–387].”
From Development of prefrontal cortex (2022) · cites this paper as [385]
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“Though cognitive deficits can independently occur in seizure disorders as a direct result of disease etiology, such as trauma, epileptic activity contributes to, and exacerbates cognitive decline (Holmes, 2015).”
From Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms (2022) · cites this paper as Holmes, 2015
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Metadata
- Authors
- Holmes, G. L.
- Affiliations
- University of Vermont (US)
- Corresponding author
- Holmes, Gregory L
- ORCID
- Holmes, Gregory L
- Venue
- Epileptic Disorders
- Publisher
- Wiley
- Published
- 2015-06
- Volume
- 17
- Issue
- 2
- Pages
- 101-116
- ISSN
- 1294-9361 (ISSN-L)
- 1950-6945
- PMC
- PMC5410366
- OpenAlex
- W1606616855
- Cited by
- 334
- References
- 89
- Citations by year
- 2026: 32 · 2025: 37 · 2024: 48 · 2023: 28 · 2022: 52 · 2021: 43 · 2020: 42 · 2019: 23 · 2018: 8 · 2017: 7 · 2016: 13 · 2015: 1
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Epileptic Disorders (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS073083, NS074450, NS073083, R01NS078279, R01NS074450)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- cognitive impairment, epilepsy, epilepsy comorbidity, epilepsy pathophysiology, recurrent seizures, signaling pathways
- MeSH terms
- Animals, Cognition Disorders, Epilepsy, Humans, Nerve Net, Brain Waves
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